[Urinary excretion of hydroxyproline in patients with lesions of the peripheral nervous system]. / Wydalanie hydroksyproliny w moczu u chorych z uszkodzeniem obwodowego ukladu nerwowego.

Seventy-one urinary total hydroxyproline determinations were carried out by the Prockop-Udenfried method in 61 patients with central nervous system damage (Bell's palsy, pareses of small muscles or muscle groups caused by damage to peripheral nerves or nerve roots, brachial plexus injury and motor polyneuropathy) and in 45 controls. Significantly raised urinary hydroxyproline excretion was found in cases of brachial plexus injury and severe motor polyneuropathy. This excretion in subgroups of Bell's palsy and damage to single nerves or roots was not significantly different from that in controls.

[Urinary excretion of hydroxyproline by patients with multiple sclerosis]. / Wydalanie hydroksyproliny w moczu u chorych ze stwardnieniem rozsianym.

Total urinary hydroxyproline was determined 79 times by the Prockop-Udenfried method in 61 patients with multiple sclerosis. All patients had the pyramidal syndrome. Depending on the intensity of paresis at the time of the study the patients were divided into two groups: Group I--patients with slight paresis. Group II--patients with major paresis or paralysis. The control group comprised 45 healthy subjects. The mean urinary hydroxyproline excretion was in both groups as a whole and in each group separately not different significantly from that in the control group. The values of hydroxyproline excretion depended on the duration of paresis, and were highest in both groups 2 weeks to 1 year after the onset of paresis, and then they decreased in two successive time periods: 1-5 and 5-17 years of the disease. The values of hydroxyproline excretion were significantly above the control level only in patients with severe paresis or paralysis of up to 1 year duration, and might have been due to increased catabolism of collagen in the bones of the paralysed extremities in the period of the so called acute osteoporosis.

[Urinary excretion of hydroxyproline in patients with ischemic stroke]. / Wydalanie hydroksyproliny w moczu chorych z niedokrwiennym udarem mózgu.

Urinary excretion of total hydroxyproline being an indicator of the metabolism of systemic collagen was determined in 104 patients with ischaemic stroke and in 45 controls. The determinations were done by the method of Prockop-Udenfried in the urine of patients after 2 days on a non-collagen diet. Increased excretion of hydroxyproline was found in the subgroup of patients with high-grade paresis or paralysis, while in the subgroup with mild paresis these results were normal. The excretion of hydroxyproline in patients with severe paralysis increased during 3-60 days after stroke and then decreased in the period from 60 days to 5 years.