[Influence of brachytherapy on the behavior of immunologic circulating complexes in the blood serum of patients with cervix cancer]. / Wplyw brachyterapii na zachowanie sie krazacych kompleksów immunologicznych w surowicy chorych na raka szyjki macicy.

Applying the EA and EAC rosettes production inhibition method the appearance and levels of immunologic circulating complexes (CI) in the blood serum of 32 patients with cancer of the uterine cervix and in 100 healthy persons have been evaluated. Immunocomplexes have been examined prior to the initiation of brachytherapy and after three successive applications of radioactive cesium isotope (137Cs). Three successive application of the radioisotope contained and in the uterine probe have been used and a dose up to 2000 cGy in 16-18 hours given on each application. It has been shown that prior to treatment and in some stages of clinical advancement the levels of CI evaluated by two tests are significantly higher as compared with controls. Significant increase of CI levels after successive application of cesium has been also noted. The appearance of CI in patients with cervical cancer indicates the presence of tumor-specific and/or viral antigens in such patients. The elevation of CI levels after cesium application may be result of accelerated release of antigens in the course of brachytherapy.

[Circulating immune complexes in the blood serum of patients with untreated cervical cancer--their occurrence and quantitative analysis]. / Krazace kompleksy immunologiczne w surowicy nie leczonych chorych na raka szyjki macicy--wystepowanie i ocena ilosciowa.

Circulating immunological complexes (KI) are one of the parameters of humoral immunity. The occurrence of KI was found in the course of neoplastic diseases both in animals and humans. They are formed as a result of interaction of neoplastic antigens with specific tumor antibodies. Immunological complexes may be favourable or unfavourable to the modulation of effector mechanisms directed against neoplastic cells. In spite of extensive research, the participation of KI in immunological neoplastic response has not been clearly defined. The quantitative analysis of KI in the serum of patients with neoplasms revealed that the levels of KI may correlate with the degree of the progression of the disease, which has been shown for example in malignant melanoma, embryonal neuroma and carcinoma of the breast. The investigation of KI in the serum of patients with cervical carcinoma is rarely reported. The present paper shows 71 patients with squamous epithelial cervical carcinoma in various stages of progression, patients not receiving therapy. The evaluation of KI was made by means of two methods: test of inhibition of forming rosettes EA and inhibition of forming rosettes EAC. The authors of the few reports on the subject agree (which was also confirmed in our research) that the serum of patients with cervical carcinoma reveals the presence of KI. The frequency of occurrence and levels of KI may correlate with the degree of progression of a neoplastic process.

[Occurrence of circulating immune complexes in the blood serum of patients with cervical cancer prior to treatment]. / Wystepowanie krazacych kompleksów immunologicznych w surowicach chorych na raka szyjki macicy przed leczeniem.

In the blood serum of 71 patients before treatment with cervical carcinoma and in 100 healthy women from the health services working staff, the occurrence of circulating immunologic complexes (CI) has been estimated applying the rosette EA and EAC inhibition test. The presence of CI has been proved and the frequency of positive results increases together with the stage of advancement of the neoplastic process. It appears that the CI examination should be regarded as a significant parameter in monitoring the course of treatment.