RESUMO
We studied allergenic, immunogenic, and skin-irritating effects of deicing chemicals HCM (Volgograd), Bishofit (Turkmenia), and Nordix-P (Russia) in model experiments on various types of laboratory animals (rats, mice, rabbits). All the studied deicing chemicals exhibited weak immunotoxic activity and in high doses can cause delayed-type hypersensitivity reaction that manifested in skin irritant effect on the skin and produced a suppressive effect on the humoral immunity. The modified method for assessing skin irritation proposed by us is more sensitive than standard methods.
Assuntos
Alérgenos/farmacologia , Glicerol/farmacologia , Hipersensibilidade Tardia/induzido quimicamente , Irritantes/farmacologia , Sais/farmacologia , Animais , Feminino , Cobaias , Humanos , Hipersensibilidade Tardia/imunologia , Imunidade Humoral/efeitos dos fármacos , Masculino , Camundongos , Camundongos Endogâmicos BALB C , Coelhos , Ratos , Federação Russa , Pele/efeitos dos fármacos , Pele/imunologia , Meios de TransporteRESUMO
In accordance with international approaches the ranking of permissible levels of chemicals in the soil for the Russian Federation was performed with the use of actual maximum permissible concentration (MPC), there were scientifically substantiated 33 standardsfor 26 substances and their combinations in the soil, differentiatedfor 6 groups offunctional areas for soil use. There is presented the algorithm determining the procedure for the establishment of MPC for unstudied chemicals for various functional areas of soil of populated areas, as well as draft of amendments to existing sanitary-hygienic regulations prior to processing the latter in accordance with modern requirements.
