[Survival analysis of 104 cases of osteosarcoma with lung metastases].

Objective: To investigate the prognosis of osteosarcoma patients with lung metastases and its correlated factors. Methods: The clinical data of 104 osteosarcoma patients with lung metastasis from April 2007 to September 2015 were retrospectively analyzed. Univariate analysis was performed using Kaplan-Meier and Log rank test. Multivariate Cox regression was applied to analyze independent prognostic factor for patient survival. Results: The one-year, two-year and five-year survival rates of the 104 osteosarcoma patients with lung pulmonary metastasis were 93.3%, 61.5% and 11.5%, respectively, and the median survival time was 33 months. The univariate analysis revealed that number of lung metastases, objective response of first-line chemotherapy and therapeutic methods for lung metastases were significant prognostic factors for patient survival, whereas gender, age, time to lung metastasis and time to other metastasis were not (P>0.05). The multivariate analysis indicated that number of lung metastases, objective response of first-line chemotherapy and therapeutic methods for lung metastases were independent significant prognostic factors for patient survival. Conclusions: The prognosis of osteosarcoma patients with advanced lung metastases and active treatment is better. Surgery and adjuvant chemotherapy could effectively prolong survival time for osteosarcoma patients with pulmonary metastasis.

The diagnostic and prognostic values of microRNA-21 in patients with gastric cancer: a meta-analysis.

OBJECTIVE: Previous studies demonstrated the pivotal role of miR-21 in the pathogenesis and progression of gastric cancer. This meta-analysis was designed to confirm the diagnostic and prognostic value of microRNA-21 (miR-21) in gastric cancer and to investigate the influence of samples on the results of miR-21 detection. MATERIALS AND METHODS: A literature search was conducted in PubMed and Embase databases up to August 2016. The pooled sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic odds ratio (DOR), and area under the summary receiver-operating characteristic (AUC) were calculated by Meta-Disc (version 14.0) or RevMan 5.3 software. RESULTS: Ten studies including 516 patients with gastric cancer and 239 healthy controls were selected. Pooled sensitivity (0.74, 95% CI: 0.69-0.79), specificity (0.81, 95% CI: 0.76-0.86), PLR (3.85, 95% CI: 3.00-4.94), NLR (0.22, 95% CI: 0.31-0.45), and DOR (13.07, 95% CI: 8.81-19.39) as well as AUC (0.8561 ± 0.0204) indicated the good diagnostic accuracy of miR-21 in detecting gastric cancer. The prognostic value of miR-21 for lymph node metastasis in gastric cancer was also demonstrated by the pooled sensitivity (0.56, 95% CI: 0.48-0.64), specificity (0.62, 95% CI: 0.53-0.71), PLR (2.02, 95% CI: 0.90-4.54), NLR (0.58, 95% CI: 0.45-0.75), and DOR (3.50, 95% CI: 1.04-11.83) as well as AUC (0.6673 ± 0.0469). Subgroup analyses showed that the samples used to detect miR-21 were the source of heterogeneity could affect the diagnostic or prognostic value of miR-21 in gastric cancer. CONCLUSIONS: miR-21 can be used for the diagnosis of gastric cancer and prognosis of lymph node metastasis in gastric cancer.

Body composition as a predictor of blood pressure in three communities in Guangdong province, China.

The aim of this study was to compare mean blood pressure (BP), anthropometric and body compositional measurements in three Chinese communities and to examine relationships between BP and body composition in these communities. A total of 935 adult (aged >= 25 years) men and women were randomly sampled from three communities (Chauzhou County speaking Teochew, Meixian County speaking Hakka, and Xinhui speaking Cantonese) in Guangdong Province, China. Self-administered questionnaires about food habits, lifestyle and health status were completed. Body weight, stature, waist and hip circumferences and systolic and diastolic blood pressures were measured. Body mass index, waist to hip ratio, fat free mass, total body fat mass and the percentage body fat were calculated to assess body composition. No significant differences were found in stature, body mass index, umbilical circumference, hip circumference, fat free mass, percentage body fat and defined hypertension between the three communities. However, the waist to hip ratio was lower in Chauzhou men than Meixian women. The mean BPs were different between the communities and mean blood pressure was the highest in the Chauzhou community. Intra-community non-parametric relations between BP and body composition were found mostly in men with increased total and abdominal fatness positively related to BP. The relationships of the aggregate communities with blood pressure were found consistent with those for intra-community analyses, although the body fatness-blood pressure relationship was then evident without exception. Anthropometrically assessed body composition predicts BP in Chinese men, but to a lesser extent, in Chinese women in Guangdong Province, China.

Cigarette smoking and socio-economic indicators as determinants of body fatness in three Southern Chinese communities of China.

Obesity is one of the major risk factors for cardiovascular disease and non-insulin dependent diabetes mellitus. This study describes cigarette smoking and the socio-demographic differences of body fatness in three sub-ethnic distinctive communities in Guangdong Province, China. In this study, 935 adult Chinese (Chauzhou - 203 men and 111 women; Meixian - 169 men and 140 women; Xinhui - 194 men and 118 women) were randomly sampled from three communities. A standard protocol was used to measure stature, body weight, waist and hip circumferences. Body mass index (BMI) and waist-to-hip circumference ratio (WHR) were calculated as measures of total body fatness and abdominal body fatness, respectively. The questionnaire was self-administered and demographic and lifestyle factors were assessed. WHR was positively related to age in men (p=0.0001) and in women (p=0.0001) while BMI was associated with age only in women (p=0.0001). In women, WHR was significantly related to education levels after adjusting for age and BMI (p=0.0300). In men, BMI differed by educational level, after adjusting for age and WHR (p=0.0329). BMI was significantly associated with occupational status in men, after adjusting for age and WHR (p=0.0004). Gross household income was significantly associated with WHR in men, after adjusting for age and BMI (p=0.0469). Male smokers had a significantly lower mean BMI than the non-smokers, after adjusting for age and WHR (p=0.0037). Marital status was not related to body fatness measurements after adjusting for age and WHR. The differences in body fatness in Chinese living in Southern China can not be totally explained by educational level, occupational status, marital status, gross household income and cigarette smoking, particularly in women. Age was the only consistent predictor of abdominal body fatness in both men and women and also of total body fatness in women.