RESUMO
Dynamics of circulation and elimination of low and medium molecular weight substances and lipopolysaccharides of Gramm negative bacteria were studied during prolonged veno-venous haemofiltration in patients with Gramm negative sepsis. Positive effect of HyperHAES solution for endotoxicosis compensation has been defined in the study. HyperHAES can be used repeatedly during prolonged veno-venous haemofiltration.
Assuntos
Infecções por Bactérias Gram-Negativas/terapia , Hemofiltração/métodos , Derivados de Hidroxietil Amido/administração & dosagem , Sepse/terapia , Infecções por Bactérias Gram-Negativas/sangue , Infecções por Bactérias Gram-Negativas/microbiologia , Hemodinâmica/efeitos dos fármacos , Humanos , Derivados de Hidroxietil Amido/química , Derivados de Hidroxietil Amido/farmacologia , Soluções Hipertônicas , Soluções Isotônicas , Lipopolissacarídeos/sangue , Concentração Osmolar , Estudos Prospectivos , Sepse/sangue , Sepse/microbiologia , Fatores de Tempo , Resultado do TratamentoRESUMO
The role of reamberin, a succinate-containing infusion preparation in correlation of pulmonary metabolic and respiratory disturbances in patients with obstetric puerperal sepsis was estimated. The prospective randomized study enrolled 43 patients with puerperal obstetric sepsis complicated by polyorganic deficiency (SOFA 8-10). Nineteen patients of the 1st group and 24 patients of the 2nd group were additionally treated with reamberin in a dose of 800 ml/day for 8 days. The venous and arterial difference by glucose, lactate, pyruvate, diene conjugates, malondialdehyde and ceruloplasmin was investigated. The blood gases were determined with the Ciba Corning 45 apparatus. Lower metabolic activity of the lungs with prevalence of the glucose anaerobic metabolism and lower activity of the intrapulmonary antioxidant protection were observed in the patients with obstetric sepsis. The use of reamberin in the complex therapy of obstetric sepsis promoted maintenance of the initial balance and anaeroibic and aerobic pulmonary metabolism, thus providing shorter terms of the decompensation and recovery of the lungs respiratory function.
