RESUMO
It was found in acute experiments on white rats that injection of Salmonella typhimurium lipopolysaccharide activates renin-angiotensin-aldosterone system (RAAS) and causes oligohydruria form of acute renal failure (ARF). Enalapril, angiotensin-converting enzyme, being injected simultaneously with endotoxin, increases diuresis, glomerular filtration rate, electrolytes excretion and reabsorption by proximal tubules, decreases proteinuria and blood nitrogen-down to the normal. Thus, RAAS takes part in endotoxemia ARF induction and enalapril has protective effect.
Assuntos
Injúria Renal Aguda/etiologia , Endotoxinas/sangue , Sistema Renina-Angiotensina/fisiologia , Salmonella typhimurium , Toxemia/complicações , Injúria Renal Aguda/fisiopatologia , Inibidores da Enzima Conversora de Angiotensina/uso terapêutico , Animais , Avaliação Pré-Clínica de Medicamentos , Quimioterapia Combinada , Enalapril/uso terapêutico , Masculino , Oligúria/etiologia , Oligúria/fisiopatologia , Prednisolona/uso terapêutico , Ratos , Sistema Renina-Angiotensina/efeitos dos fármacos , Toxemia/fisiopatologiaRESUMO
The effects of prostacyclin and its stable analogue MM-706 on renal function were examined in rats with sublimate nephropathy. Prostacyclin was shown to attenuate renal dysfunctions by increasing glomerular filtration rate and water and salt reabsorption. MM-706 produced more pronounced protective effects and restored the filtration and reabsorption up to the level observed in control rats.
Assuntos
Epoprostenol/análogos & derivados , Epoprostenol/uso terapêutico , Nefropatias/tratamento farmacológico , Rim/efeitos dos fármacos , Animais , Avaliação Pré-Clínica de Medicamentos , Rim/fisiopatologia , Nefropatias/sangue , Nefropatias/induzido quimicamente , Nefropatias/fisiopatologia , Masculino , Cloreto de Mercúrio , RatosRESUMO
The influence of a stable analogue of prostacyclin on the renal function and parameters of hemostasis was investigated in experiments on animals with the nephrotic form of acute renal insufficiency. Diuresis, glomerular filtration, water and sodium reabsorption in the presence of diminished intravascular coagulation were recovered after two injections of the compound in a dose of 115 micrograms/kg.
Assuntos
Injúria Renal Aguda/fisiopatologia , Coagulação Sanguínea/fisiologia , Modelos Animais de Doenças , Epoprostenol/uso terapêutico , Rim/fisiopatologia , Injúria Renal Aguda/tratamento farmacológico , Animais , Coagulação Sanguínea/efeitos dos fármacos , Testes de Coagulação Sanguínea , Diurese/efeitos dos fármacos , Diurese/fisiologia , Taxa de Filtração Glomerular/efeitos dos fármacos , Taxa de Filtração Glomerular/fisiologia , Rim/efeitos dos fármacos , Testes de Função Renal , Masculino , RatosRESUMO
A conclusion on relationships of the septum with both the antidiuretic and antinatriuretic systems in the regulation of the aqueous-electrolytic balance and renal function has been drawn as a result of the study of the drinking behaviour and renal reaction after the destruction of the lateral septal nucleus (LSN). This conclusion is based on the revealed increase in the urinary excretion of sodium, osmotically active substances, creatinine, titrating acids and ammonia after the LSN destruction. Moreover, an increase of the vasopressin level in the blood plasma, a decrease of aldosterone concentration as well as an activation of the drinking behaviour are noted.
Assuntos
Eletrocoagulação , Rim/fisiologia , Núcleos Septais/cirurgia , Animais , Diurese/fisiologia , Ingestão de Líquidos/fisiologia , Ratos , Sede/fisiologia , Equilíbrio Hidroeletrolítico/fisiologiaRESUMO
Radioimmunoassay was conducted to study the content of triiodothyronine and thyroxine in the human milk and in the blood serum of mature and premature newborns. It was established that with the growth of the lactation period the content of triiodothyronine and thyroxine rose; it was, respectively, 0.5 +/- 0.12 and 100.3 +/- 8.4 nmol/l in colostrum, 9.2 +/- 0.7 and 271.3 +/- 14.1 nmol/l in transient milk, 11.1 +/- 1.07 and 405.0 +/- 21.4 nmol/l in fully formed milk. Fully formed milk contains three times more triiodothyronine and thyroxine than the blood serum of newborns. The mature newborns have a sufficiently formed thyroid function. The level of thyroid hormones in the blood serum of premature newborns is decreased in proportion to the stage of their prematurity. They receive the deficient hormones through the human milk. The authors recommend that the nutrition of premature newborns receiving mixed and artificial feeding should be supplemented with thyroid hormones.
Assuntos
Aleitamento Materno , Recém-Nascido Prematuro/sangue , Leite Humano/análise , Hormônios Tireóideos/análise , Colostro/análise , Feminino , Humanos , Recém-Nascido , Gravidez , Tiroxina/análise , Tri-Iodotironina/análiseAssuntos
Volume Sanguíneo , Metabolismo Energético , Rim/metabolismo , Equilíbrio Hidroeletrolítico , Animais , Masculino , RatosRESUMO
The effect of progesterone on ion-regulating kidney function was studied in experiments on albino male rats under the conditions of spontaneous and water diuresis. Kidney function was evaluated by the level of urination, sodium, potassium and creatinine excretion with regard to the glomerular filtration and tubular reabsorption in water diuresis. Five series experiments were made, including a study of the effect of progesterone on kidney function under the conditions of a low and high sodium diet, adrenalectomy and castration. Progesterone was shown to possess a pronounced natriuretic effect in sodium deficiency in the body and to cause sodium retention in a high sodium diet. Adrenalectomy and castration did not prevent the natriuretic action of progesterone. The elevated excretion of sodium was determined by an increase in its filtration charge. In all the studies sodium excretion changed with a sufficient degree of significance (P less than 0,01 = PI less than 0,05).