Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 1 de 1
Filtrar
Mais filtros











Base de dados
Intervalo de ano de publicação
1.
Vopr Onkol ; 57(1): 81-5, 2011.
Artigo em Russo | MEDLINE | ID: mdl-21598714

RESUMO

The report discusses our experimental data in support of biotherapy which uses chemotherapy and antitumor immune treatment with in vivo xenogenic transfer-factor polypeptides (TFP) isolated from lymphocytes sensitized to antigens of given tumor. After excision of primary tumor--lung carcinoma of Lewis--mice C57BL/6 were injected intraperitoneally with xenogenic TFP (200 pg/body, twice) and a cytostaic dose of cyclophosphamide. Such adjuvant chemotherapy was found to prevent metastases from spreading to the lung in 100%. The marked anti-metastatic effect of the treatment correlated with recovery of splenic cell mass and its cellular structure, higher levels of large granular lymphocytes in peripheral blood and enhanced functional activity of cytotoxic cells in vitro. Our results point to a possibility of raising efficacy of treating solid malignancies with adjuvant chemotherapy in combination with adoptive immune therapy.


Assuntos
Carcinoma Pulmonar de Lewis/prevenção & controle , Ciclofosfamida/farmacologia , Imunossupressores/farmacologia , Imunoterapia Adotiva/métodos , Neoplasias Pulmonares/prevenção & controle , Fator de Transferência/farmacologia , Animais , Antineoplásicos Alquilantes/administração & dosagem , Antineoplásicos Alquilantes/farmacologia , Carcinoma Pulmonar de Lewis/secundário , Ciclofosfamida/administração & dosagem , Imunossupressores/administração & dosagem , Injeções Intraperitoneais , Neoplasias Pulmonares/secundário , Camundongos , Camundongos Endogâmicos C57BL , Peptídeos/farmacologia , Fator de Transferência/administração & dosagem
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA