RESUMO
In this work we for the first time revealed on clinical - genetic material association between hereditary disturbances of cardiac conduction and polymorphism of 2-adrenergic receptor gene.
Assuntos
Arritmias Cardíacas/genética , Polimorfismo Genético , Receptores Adrenérgicos beta 2/genética , Feminino , Predisposição Genética para Doença , Humanos , Masculino , Pessoa de Meia-IdadeRESUMO
In this work we have demonstrated for the first time on the clinico-genetic material association between hereditary sick sinus node syndrome (SSNS) ADRA2B and eNOS genes polymorphisms. We have established predominance of homozygote genotype of more rare DD allele in patients with SSNS (28%) compared with subjects of control group (8.99%). We have found predominance of heterozygote genotype 4a/4b in patients with SSNS compared with subjects of control group (41.8 and 25.39%, respectively). The data obtained allow to suggest that eNOS gene polymorphism might be associated with SSNS.
Assuntos
Óxido Nítrico Sintase Tipo III/genética , Polimorfismo Genético , Receptores Adrenérgicos alfa 2/genética , Síndrome do Nó Sinusal/genética , Nó Sinoatrial/anormalidades , Adulto , Alelos , Eletrocardiografia , Feminino , Predisposição Genética para Doença , Homozigoto , Humanos , Masculino , Pessoa de Meia-Idade , Síndrome do Nó Sinusal/diagnósticoRESUMO
In this work we have demonstrated for the first time on the clinico-genetic material association between hereditary sick sinus node syndrome and connexin 40 gene polymorphism. We have revealed that heterozygous variant of connexin 40 gene variant is more frequent among patients with sick sinus node syndrome and their healthy relatives than in persons of control group.
