[Familial left ventricular noncompaction: phenotypes and clinical course. Results of the multicenter registry].

AIM: To analyze and demonstrate various phenotypes in patients with familial left ventricular noncompaction (LVNC). MATERIALS AND METHODS: In 2013 was created a multicenter registry of LVNC patients. On its basis 30 families with a familial LVNC were selected. RESULTS: 30 LVNC families were selected from the register. From a total of 115 people (probands and relatives) in 71 (61.7%) LVNC was diagnosed (30 probands and 41 relatives with non-compact myocardial criteria). The most common type of remodeling in patients was the dilated type (DT) (n=30), the isolated LVNC with preserved ejection fraction (EF) was slightly less common (n=23), and the hypertrophic type (GT) was detected in 8 patients. 4 patients were diagnosed with the isolated LVNC with a reduced EF. 3 patients were with a combination of non-compact myocardium with congenital heart disease and with a combination of DT and GT (DT+GT). During the analysis of cases a combination of different phenotypes in the same family was observed. The largest number of families was diagnosed with a combination of DT and the isolated LVNC with preserved EF. The development of cardiovascular complications was associated with DT. CONCLUSION: Family cases of LVNC had different types of myocardial remodeling and variants of clinical course. In one family a combination of different types of left ventricular remodeling is possible. DT is associated with the most severe clinical manifestations. The clinical picture of the isolated LVNC with preserved EF, is the most favorable, but in rare cases, serious clinical manifestations were observed.

[The combined application of yellow turpentine bathtubs and bronchodilators inhalations for the treatment of the patients presenting with chronic obstructive pulmonary disease].

This paper was designed to report the results of comparative clinical and functional studies involving 89 patients who presented with moderately severe chronic obstructive pulmonary disease and were given the combined treatment with yellow turpentine bathtubs and bronchodilators inhalations with the use of a nebulizer. The patients comprising group 1 (n=29) were treated with yellow turpentine bathtubs and bronchodilators inhalations, those making up group 2 (n=30) received monotherapy with yellow turpentine bathtubs alone, and the patients included in group 3 (n=3) served as controls treated with the use of therapeutic physical exercises and symptomatic medications analogous to those given to the patients of the two former groups. The results of the study give evidence of the advantages of the rehabilitative complex including yellow turpentine bathtubs and atrovent inhalations over two alternative therapeutic modalities attributable to its pronounced anti-inflammatory and immune-corrective activity that resulted in the generalized improvement of bronchial patency, reduction of lung hypertension, and enhancement of physical tolerance; taken together, these effects ensured the best clinical results.

[On the usefulness of including general biolong baths in the combined therapeutic and rehabiliatative treatment of the patients presenting with obstructive diseases of the respiratory organs].

Bearing in mind the important role of oxidative stress and intensification of lipid peroxidation processes in the development and progression of obstructive pathology of the respiratory organs, we deemed it appropriate to evaluate the therapeutic effect of general baths containing biolong, an agent showing the antihypoxic and antioxidative properties. The clinical and functional studies that involved 109 patients (52 with chronic obstructive pulmonary disease (COPD) and 57 with bronchial asthma (BA)) have demonstrated the advantages of application of the hydrotherapeutic modality in the patients with bronchial asthma. The therapeutic effect was due to degradation of the allergic inflammation processes, the well apparent decrease in the activity of lipid peroxidation processes, the improvement of humoral immunity, generalized reduction of bronchial obstruction, enhanced physical working capacity, and psychoemotional adaptation.

[Turpentine baths in rehabilitation of patients with chronic obstructive pulmonary disease].

We have investigated effects of turpentine baths with white emultion, yellow solution and mixed on the course of inflammation, immunocompetent system, external respiration function, pulmonary cardiohemodynamics, physical performance in patients with chronic obstructive pulmonary disease. We developed differential indications for each bath variant depending on the features of a clinical picture of the disease, comorbid pathology and revealed contraindications to their administration.

[Changes in the aggregated lymphoid nodules and in the mesenterial lymph nodes of rats after the administration of a chemotherapeutic drug complex: response similarities and differences].

Changes in the structure and cellular composition of aggregated lymphoid nodules (ALN, Peyer's patches) of the small intestine and in mesenterial lymph nodes (MLN) were studied in 82 female Wistar rats 7, 14 and 21 days following a single intraperitoneal injection of a complex of antineoplastic drugs (cyclophosphamide, adriamycine, vincristine and prednisolone). In ALN and MLN lymphoid nodules the administration of antineoplastic drugs resulted in the decrease of the number of blast cells and mitotically dividing cells, suggesting the suppression of B-cell proliferation and differentiation. At the same time, the dimensions of germinal centers in ALN lymphoid nodules were reduced, while their mantle zone size remained unchanged. On the contrary, in MLN lymphoid nodules, mantle zone was reduced, while germinal center dimensions remained constant. Possible reasons of these differences in responses of the immune organs studied to chemotherapy, are discussed.

[Heat transfer by the blood in the venous vessels of the rabbit under different temperature conditions]. / Perenos tepla krov'iu v venoznykh sosudakh krolika v razlichnykh temperaturnykh usloviiakh.

The blood temperature in the main venous vessels reflects the formation of the heat balance in the body. In the rabbit posterior vena cava, the temperature increased by 0.19 degrees C-0.26 degrees C after confluence of the kidney and liver veins and decreased by 0.20 degrees C after confluence of the lumbal veins collecting the venous blood from the back muscles and skin vessels. The venous blood temperature in the right auricle was equal to blood temperature in the abdominal artery. When the ambient temperature changed from 22 degrees C-24 degrees C to 35 degrees C-40 degrees C, the temperature in the posterior vena cava and abdominal artery decreased by 0.25 degrees C-0.35 degrees C.

[The physiologic and physical patterns of blood heat exchange with tissues and the environment]. / O fiziologicheskikh i fizicheskikh zakonomernostiakh teploobmena krovi s tkaniami i sredoi.

The temperature of arterial blood flowing to the ear and of venous blood outflowing from the latter was measured initially and under heat load in anesthetized rabbits. The partial calorimeter yielded the values of heat production from the ear (in cal/min). Heating of the animal increased the blood flow and the heat production (4- and 5-fold, resp.), the arterio venous difference remaining practically unaltered (0.8-0.9 degrees C).

[Reactions of Paneth cells of the rat jejunum to section of the vagus nerves (ultrastructural analysis)]. / Reaktsiia kletok Paneta toshchei kishki krys na vykliuchenie bluzhdaiushchikh nervov (ul'trastrukturnyi analiz).

Dynamics of ultrastructural alterations of Paneth cells (PC) of the rat jejunum have been investigated after bilateral subdiaphragmal trunkal vagotomy (7, 14, 30 and 60 days). This operation results in a profound ultrastructural rearrangement in PC organization, which is especially manifested on the 7th and 14th days. The cisterns and canaliculi of the endoplasmic reticulum dilate, the Golgi complex structure is disturbed, the matrix of mitochondria is cleared, their crists are fragmented, large vacuoles with electron transparent contents appear, total amount of the secretory granules and relative number of their immature forms increase, the secreory granules form and topography of their core is changed, small structures resembling microtubules appear in them. Beginning from the second week, morphological alterations of compensatory-adaptive character progressively increase: the number of free ribosomes grows large and large mitochondria appear.