Chewing Ability and the Quality of Life: A Cross-Sectional Study to Assess the Relationship Between Tooth Wear and Oral Health.

INTRODUCTION: It is important to understand how a very common prevalent condition of tooth wear (TW) impacts a person's day-to-day oral health. An emerging concept of measuring the parameter of oral health-related quality of life (OHRQoL), which evidently impacts the daily living of a person, makes it practical to examine the correlation between TW and OHRQoL. For measuring the OHRQoL, we can apply various methods, and the most effective is the use of the Oral Health Impact Profile (OHIP) questionnaire. Accordingly, the aim of this study was to assess the correlation between TW and the OHRQoL among adult patients attending a dental college and hospital. METHODS: A cross-sectional research was performed on patients who visited the outpatient department of Teerthanker Mahaveer Dental College and Research Centre, Moradabad, India. Initially, the sociodemographic details of patients, including their oral hygiene and dietary habits, were recorded. This step was followed by the assessment of TW using the Smith and Knight TW index. Then, the translated and validated version of the OHIP questionnaire was filled up, in which the patients were asked to rate each question on a Likert scale, with five points ranging from 0 to 4, where 0 = never, 1 = hardly ever, 2 = occasionally, 3 = fairly often, and 4 = very often. RESULTS: Based on a clinical examination on 630 subjects and the OHIP questionnaire responses from the participants, a significantly remarkable association (p ≤ 0.05) was found using a chi-square test between TW and the OHRQoL. In particular, TW was linked to other sociodemographic data and various lifestyle, dietary, and drinking habits. Along with the OHRQoL, TW also showed a positive correlation with gender. Using the chi-square test, a statistically significant association between age and TW was observed, with p-value = 0.004. Meanwhile, the place of residence did not show any association with TW. Educational qualifications of patients, visits to dental clinics, and reasons for dental visits showed very significant association with TW. Oral hygiene aids, materials used, frequency of brushing, and brushing technique did not have any association with TW as per the results obtained. A highly significant association was found between consumption of fruit drinks, citric drinks, and beverages and TW in the adult patients. Among all the domains of the OHIP questionnaire, the physical pain domain was the most affected, followed by the physical disability domain. CONCLUSION: We conclude that TW has a direct association and positive correlation with the OHRQoL. As TW was increasing, so were the OHIP values, which indicated a lesser OHRQoL. The study also presents information on how to maintain a regular and healthy dietary lifestyle and oral hygiene to combat the impacts of TW.

Exploring the Synergistic Association Between Oral Health Status and Oral Health Literacy Among College Students: A Cross-Sectional Study.

INTRODUCTION: Oral health is often viewed as a significant component for an indication of good general health or for good well-being together with a decent quality of life. Health literacy is considered a crucial factor in improvising a good life or excellent health. Oral health literacy (OHL) is the ability necessary for people to identify the factors that lead to poor oral health, learn and put into practice the essentials of effective oral self-care behaviors, and communicate with oral healthcare professionals in order to schedule appointments, put their names on waiting lists for dental care, and locate the dentist's office. AIM AND OBJECTIVES: To evaluate students' oral health, their OHL, to determine the relationship between their oral health status and OHL, and finally to suggest preventive measures for the benefit of public health. MATERIALS AND METHOD: At Teerthanker Mahaveer University, a cross-sectional study involving 1500 participants, ages 18 to 25, was conducted on students studying nursing, physiotherapy, paramedicine, engineering, and law. Their informed consent was obtained. The Rapid Estimate of Adult Literacy in Dentistry (REALD-99) was used to gauge OHL levels, and the WHO's 1997 Oral Health Survey was used for their clinical evaluation. RESULTS: The mean REALD score was significantly higher in nursing students (88.32±6.46), followed by physiotherapy college (82.46±9.11), paramedical college (70.54±10.95), law college (46.52±7.74), and least in engineering college (38.80±10.65). The difference in the REALD score based on college was statistically significant. Along with this, the REALD score showed a correlation with gender and location too. Except for fluorosis, all the clinical parameters of dental caries, gingival bleeding, and pockets, loss of attachment, dental fluorosis, and dental enamel were associated with OHL. CONCLUSION: The results of the current study showed a relationship between educational attainment, clinical parameters examined, and OHL, leading to the conclusion that higher OHL is related to better oral health. So, we can conclude that maintaining good oral health requires OHL.

Mining amino acid association patterns in class B GPCRs.

Class B GPCR family is a small group of receptors which are activated by peptides of intermediate length that range from 30 to 40 amino acid residues including hormones, neuropeptides and autocrine factors that mediate diverse physiological functions. They are involved in physiological processes like glucose homeostasis (glucagon and glucagon-like peptide-1), calcium homeostasis and bone turnover (parathyroid hormone and calcitonin), and control of the stress axis (corticotropin-releasing factor). Most of the GPCR structures and their functions are still unknown. Thus, the study of amino acid association patterns can be useful in prediction of their structure and functions. In view of above, in this paper, an attempt has been made to explore amino acid association patterns in class B GPCRs and their relationships with secondary structures and physiochemical properties. The fuzzy association rule mining is employed to take care of uncertainty due to variation in length of sequences. The association rules have been generated with the help of patterns discovered in the sequences.

A model for the evaluation of domain based classification of GPCR.

G-Protein Coupled Receptors (GPCR) are the largest family of membrane bound receptor and plays a vital role in various biological processes with their amenability to drug intervention. They are the spotlight for the pharmaceutical industry. Experimental methods are both time consuming and expensive so there is need to develop a computational approach for classification to expedite the drug discovery process. In the present study domain based classification model has been developed by employing and evaluating various machine learning approaches like Bagging, J48, Bayes net, and Naive Bayes. Various softwares are available for predicting domains. The result and accuracy of output for the same input varies for these software's. Thus, there is dilemma in choosing any one of it. To address this problem, a simulation model has been developed using well known five softwares for domain prediction to explore the best predicted result with maximum accuracy. The classifier is developed for classification up to 3 levels for class A. An accuracy of 98.59% by Naïve Bayes for level I, 92.07% by J48 for level II and 82.14% by Bagging for level III has been achieved.