Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 3 de 3
Filtrar
Mais filtros











Base de dados
Intervalo de ano de publicação
2.
Clin Case Rep ; 5(5): 591-593, 2017 05.
Artigo em Inglês | MEDLINE | ID: mdl-28469855

RESUMO

Metastatic male occult HER2-positive breast cancer can be successfully treated with trastuzumab monotherapy.

3.
Biochem Biophys Res Commun ; 377(2): 573-578, 2008 Dec 12.
Artigo em Inglês | MEDLINE | ID: mdl-18930710

RESUMO

Rap1 and Rap2 are similar Ras-like G proteins but perform distinct functions. By the affinity chromatography/mass-spectrometry approach and the yeast two-hybrid screening, we identified Misshapen/NIKs-related kinase (MINK) as a novel Rap2-interacting protein that does not interact with Rap1 or Ras. MINK is a member of the STE20 group of mitogen-activated protein kinase kinase kinase kinases. The interaction between MINK and Rap2 was GTP-dependent and required Phe39 within the effector region of Rap2; the corresponding residue in Rap1 and Ras is Ser. MINK was enriched in the brain, and both MINK and its close relative, Traf2- and Nck-interacting kinase (TNIK), interacted with a postsynaptic scaffold protein containing tetratricopeptide repeats, ankyrin repeats and a coiled-coil region (TANC1) and induced its phosphorylation, under control of Rap2 in cultured cells. These are novel actions of MINK and TNIK, and consistent with a role of MINK as a Rap2 effector in the brain.


Assuntos
Encéfalo/metabolismo , Venenos de Crotalídeos/metabolismo , Lectinas Tipo C/metabolismo , Proteínas Serina-Treonina Quinases/metabolismo , Proteínas rap de Ligação ao GTP/metabolismo , Sequência de Aminoácidos , Animais , Pareamento Cromossômico , Venenos de Crotalídeos/genética , Quinases do Centro Germinativo , Humanos , Lectinas Tipo C/genética , Camundongos , Dados de Sequência Molecular , Fosforilação , Proteínas Serina-Treonina Quinases/genética , Ratos
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA