Comparison of the IHC Markers CD138 and CD43 in Oral Leukoplakia: An Original Research.

Background: In the clinical practice, one of the most common suspicious lesions that may be potentially malignant is oral leukoplakia. Globally, the rate at which it turns malignant varies. This study examines the levels of markers CD138 and 43 in oral leukoplakia. Materials and Methods: Twenty archival blocks of confirmed epithelial dysplasia were taken from the Department of Oral Pathology. These were processed for the identification of markers CD138 and 43 through Immuno Histo Chemistry (IHC). The blocks were divided equally for both the markers. Results: There was a noticeable difference in staining intensity between dysplastic tissue and nondysplastic epithelium. However, CD138 expression was low or weak in dysplastic epithelium. CD43 expression was negative in all nonhematopoietic tissues. Conclusion: Genes that are cancer associated have been found to have incredibly different impacts in numerous tissues during the multistep process of oral carcinogenesis. In tissues undergoing dysplastic changes, CD138 expression was shown to be decreased, which could point out the malignant changes initiated in the epithelium of the oral tissues.

Relationship of Burnout and Extra-Curricular Activities among Dental Students: An Original Research.

Introduction: "Burnout syndrome (BS)" is a work-associated condition which is frequently observed in medical professionals, especially students. Extra-curricular activities (ECAs) are one of the coping techniques that students employ to deal with stress and exhaustion. Goal: The study's goal is to evaluate dental students' levels of burnout and how it correlates with their participation in ECAs. Materials and Procedures: In South India, a dentistry school conducted a cross-sectional questionnaire research with its students. Both the regular and supplemental batches of students from the first year through the fifth year (internship) were included. The "Maslach Burnout Inventory Student Survey", which has 15 items in three areas-"Emotional Fatigue (EE), Cynicism (CY), & Professional Efficacy (PE)"-was used to assess burnout. A 5-point Likert scale was used to grade each response. Poisson log linear model and the Mann-Whitney U test were employed. The threshold for statistical significance was 5 out of 100. Results: Four hundred participants were finalized after the criteria. Over 80% of the participants were women students as in accordance with the routine proportion of the dental students. The participants' average age was 22.1 ± 12 years. Burnout was seen in nearly 20% of subjects. Significant variation was seen for all the three domains of the burnout when they were compared against the ECA (P = 0.019(EE), 0.003(CY), and 0.005(PE)). Conclusion: It is safe to say that among the participants, burnout is a common occurrence. There is a need for early detection of burnout in dental students and prompt, efficient management.

Melatonin Enhances the Photosynthesis and Antioxidant Enzyme Activities of Mung Bean under Drought and High-Temperature Stress Conditions.

Mung bean, a legume, is sensitive to abiotic stresses at different growth stages, and its yield potential is affected by drought and high-temperature stress at the sensitive stage. Melatonin is a multifunctional hormone that plays a vital role in plant stress defense mechanisms. This study aimed to evaluate the efficiency of melatonin under individual and combined drought and high-temperature stress in mung bean. An experiment was laid out with five treatments, including an exogenous application of 100 µM melatonin as a seed treatment, foliar spray, and a combination of both seed treatment and foliar spray, as well as absolute control (ambient condition) and control (stress without melatonin treatment). Stresses were imposed during the mung bean's reproductive stage (31-40 DAS) for ten days. Results revealed that drought and high-temperature stress significantly decreased chlorophyll index, Fv/Fm ratio, photosynthetic rate, stomatal conductance, and transpiration rate through increased reactive oxygen species (ROS) production. Foliar application of melatonin at 100 µM concentration enhanced the activity of antioxidant enzymes such as superoxide dismutase, catalase, and ascorbate peroxidase and the concentration of metabolites involved in osmoregulation and ion homeostasis; thereby, it improves physiological and yield-related traits in mung bean under individual and combined stress at the reproductive stage.

Maxillary tumour as first sign of endocrine abnormality: A report of a rare case.

Brown tumour is a non-neoplastic giant cell lesion resulting as a complication of hyperparathyroidism (HPT). HPT usually results from increased secretion of parathyroid hormone (PTH). We present a rare case of brown tumour of anterior maxilla presenting as a first sign of previously undiagnosed secondary HPT, to emphasise that giant cell lesions of jaw bones should routinely be screened for PTH levels to rule out underlying endocrine abnormalities and oral manifestation is the earliest manifestation of many systemic diseases and careful evaluation of oral cavity by physician gives information to underlying systemic pathology.