RESUMO
Authors analyzed biochemical (data obtained by proton MR spectroscopy) and hemodynamic ( data of fMRI) characteristics of the prefrontal cortex in 7 patients with juvenile shift-like schizophrenia examined during remission after the first episode and in 8 mentally healthy subjects matched for sex and age. The between-group differences in the tested parameters were not found, however, the neurobiological features of the prefrontal cortex were correlated with the psychopathological symptoms assessed with the PANSS.
Assuntos
Hemodinâmica , Imageamento por Ressonância Magnética , Córtex Pré-Frontal/irrigação sanguínea , Córtex Pré-Frontal/fisiopatologia , Esquizofrenia/fisiopatologia , Ácido Aspártico/análogos & derivados , Ácido Aspártico/análise , Biomarcadores/análise , Creatina/análise , Feminino , Humanos , Masculino , Fosfocreatina/análise , Córtex Pré-Frontal/química , Adulto JovemRESUMO
An objective of the study was to compare sensitivity of low- and extra high-field frequency magnetic resonance (MR) tomography of acutest intracerebral hematomas (ICH) and to assess differences between symptoms in obtained images. A study was conducted using experimental ICH in rats (n=6). Hematomas were formed by two injections of autologic blood into the brain. MR-devices "Bio Spec 70/30" with magnetic field strength of 7 T and "Ellipse-150" with magnetic field strength of 0,15 T were used in the study. MR-tomography was carried out 3-5 h after the injections. Both MR-devices revealed the presence of pathological lesion in all animals. Extra highfield frequency MR-tomography showed the specific signs of ICH caused by the paramagnetic effect of deoxyhemoglobin in T2 and T2*-weighted images (WI) and low frequency MR-tomography - in T2*-WI only. The comparable sensitivity of low- and extra high-field frequency MR-devices in acutest ICH was established.
Assuntos
Hemorragia Intracraniana Traumática/diagnóstico , Imageamento por Ressonância Magnética/métodos , Doença Aguda , Animais , Modelos Animais de Doenças , Masculino , Ratos , Sensibilidade e Especificidade , Índices de Gravidade do TraumaRESUMO
The relationship between MRI-parameters of frontal lobes and levels of autoantibodies to nerve growth factor (Aab-NGF) in the blood serum of patients with schizophrenia and their relatives was studied. The negative correlation between the Aab-NGF level and the total volume of frontal lobes (r= -0,59; p<0,01) was found in the group of patients. No significant correlations were found in the control groups of healthy subjects without family history of schizophrenia and relatives of patients. The authors concede that Aab-NGF may play a substantial role in the development of neuromorphological changes in schizophrenia.
Assuntos
Autoanticorpos/sangue , Autoimunidade/imunologia , Lobo Frontal/patologia , Fator de Crescimento Neural/sangue , Esquizofrenia/sangue , Adulto , Progressão da Doença , Feminino , Humanos , Técnicas Imunoenzimáticas , Imageamento por Ressonância Magnética , Masculino , Pessoa de Meia-Idade , Prognóstico , Esquizofrenia/diagnóstico , Esquizofrenia/imunologia , Índice de Gravidade de DoençaRESUMO
The aim of this study was to assess the possibility of revealing intracerebral hematomas (ICH), using MRI, within the first hours after onset and to determine their MRI semiotics features. Thirty animals with experimental ICH were studied. A method of two-stage introduction of autologous blood was used to develop ICH as human spontaneous intracranial hematomas. Within 3-5h after blood introduction to the rat brain. The control MRI was performed in the 3rd and 7th days after blood injections. ICH were definitely identified in the first MRI scans. The MRI semiotics features of acute ICH and their transformations were assessed. The high sensitivity of MRI to ICH as well as the uniform manifestations in all animals were shown. In conclusion, the method has high specificity for acute ICH detection.