RESUMO
PURPOSE: To investigate the role of vitreous body changes in the pathogenesis of aggressive posterior retinopathy of prematurity. MATERIAL AND METHODS: The study included 60 children with stage 4-5 retinopathy of prematurity demonstrating either classical or aggressive posterior form of progression. In all cases vitreous samples for laboratory testing were taken during surgery. RESULTS: The study showed that aggressive posterior retinopathy of prematurity is associated with more significant metabolic changes in comparison with classical form of the disease. The degree of biochemical imbalance of the vitreous appeared directly related to the stage of the disease, which was determined by the type and extent of retinal detachment. Volcano-shaped retinal detachment with intensive exudation within the posterior eye segment is considered the most severe variant of aggressive posterior retinopathy of prematurity. CONCLUSION: Aggressive posterior retinopathy of prematurity is characterized by substantial disturbance of metabolism of the vitreous body, which contributes to exudation and proliferation, thus aggravating the course of the disease and worsening the prognosis.
Assuntos
Equilíbrio Ácido-Base , Descolamento Retiniano , Retinopatia da Prematuridade , Vitrectomia/métodos , Corpo Vítreo , Acidose/metabolismo , Técnicas de Diagnóstico Oftalmológico , Feminino , Idade Gestacional , Humanos , Recém-Nascido , Recém-Nascido Prematuro , Cuidados Intraoperatórios , Masculino , Avaliação de Resultados em Cuidados de Saúde , Descolamento Retiniano/etiologia , Descolamento Retiniano/metabolismo , Descolamento Retiniano/fisiopatologia , Descolamento Retiniano/cirurgia , Retinopatia da Prematuridade/complicações , Retinopatia da Prematuridade/diagnóstico , Retinopatia da Prematuridade/metabolismo , Retinopatia da Prematuridade/fisiopatologia , Índice de Gravidade de Doença , Corpo Vítreo/química , Corpo Vítreo/metabolismo , Corpo Vítreo/patologia , Corpo Vítreo/fisiopatologiaRESUMO
Cytokine monotherapy with Superlymph used in combination with the keratoprotector Applicoll in the treatment of superficial corneal layer defect resulted in rapidly alleviated inflammatory reactions, accelerated reparative processes, more qualitative epithelial defect recovery, by forming a finer scar, without opacity whereas the traditional treatment led to long-term healing and keratoleukoma in an experiment. The use of cytokine therapy with Superlymph in the complex treatment of corneal injuries and inflammation in children promoted a prompt and stable arrest of a local inflammatory process, accelerated epithelization, reduced opacity intensity, higher visual acuity, and shorter treatment.
