RESUMO
The authors studied the platelet functional properties and the brain bioelectric activity in 20 patients with acute cerebrovascular diseases before and after subcutaneous injection of 2.0 ml of racemic camphor T, as well as before and after oral taking of monobromated camphor in a dose of 0.5 g 3 times a day. The platelet aggregation was examined by the method of Born (1962) with automatic recording of aggregatograms. The brain bioelectric activity was examined using an Alvar electroencephalograph. As a result, the authors discovered an inhibitory effect of camphor preparations on the platelet aggregation. Racemic camphor T and monobromated camphor were found to produce a stimulant effect on the brain.
Assuntos
Cânfora/uso terapêutico , Infarto Cerebral/tratamento farmacológico , Plaquetas/efeitos dos fármacos , Cânfora/administração & dosagem , Circulação Cerebrovascular/efeitos dos fármacos , Ensaios Clínicos como Assunto , Eletrocardiografia , Humanos , Hipertensão/tratamento farmacológico , Arteriosclerose Intracraniana/tratamento farmacológico , Agregação Plaquetária/efeitos dos fármacosRESUMO
The paper is concerned with the results of a study of 140 patients who had had transient disorders of cerebral circulation. Among these cases 47 were subjected to a prospective observation and 93 to a retrospective one. The authors analyse 32 possible risk factors of brain stroke in patients with transient disorders of cerebral circulation. Their mathematical processing was accomplished with the aid of correlational coefficients and conditioned probabilities, detecting the highest pathogenic importance of these factors (such as disturbance of the rhythm of cardiac activity, arterial hypertension higher than 190 mm, etc). A mathematical evaluation and combination of factors was made. It was demonstrated that there is a diminution of the risk of development of ischemic stroke with development of parkinsonism in patients with transient disorders of cerebral circulation. The authors give recommendations for prophylactic treatment in order to prevent strokes in this group of patients.