The bone microstructure from anterior cruciate ligament footprints is similar after ligament reconstruction and does not affect long-term outcomes.

PURPOSE: The purpose of this study was to assess the quality of the bone tissue microstructure from the footprints of the anterior cruciate ligament (ACL) and its impact on late follow-up outcomes in patients who undergo anterior cruciate ligament reconstruction (ACLR). METHODS: The records of 26 patients diagnosed with a completely torn ACL who underwent ACLR were collected. During the surgery performed using the Felmet method, bone blocks from the native ACL footprints were collected. The primary measurements of the bone microstructure were made using a microtomographic scanner. In late follow-up examinations, a GNRB arthrometer was used. RESULTS: There was no significant difference in the bone microstructure assessed using micro-CT histomorphometric data according to the blood test results, plain radiographs, age or anthropometric data. There was no difference in the bone volume/total volume ratio or trabecular thickness in the area of the native ACL footprints. Routine preoperative examinations were not relevant to the quality of the bone microstructure. The elapsed time from an ACL injury to surgery had no relevance to the results of arthrometry. CONCLUSION: The similarities in the microstructure of bone blocks from ACL footprints from the femur and tibia allow the variable use of these blocks to stabilize grafts in the Felmet method. The bone microstructure is not dependent on the time from injury to surgery. Histomorphometric values of the structure of the femoral and tibial ACL footprints have no impact on the long-term stability of the operated knee joint. TRIAL REGISTRATION: The approval of the Bioethics Committee of the Silesian Medical Chamber in Katowice, Poland (resolution 16/2014) was given for this research. LEVEL OF EVIDENCE: II.

[Effect of cyclophosphamide on bone remodeling in rats]. / Wplyw cyklofosfamidu na procesy przebudowy kosci u szczurów.

Neoplasms, with or without metastases in bones, can induce pathological bone remodeling, leading to systemic bone resorption and hypercalcemia or osteomalacia and normocalcemia. The aim of the present study was to investigate the effect of a cytostatic--cyclophosphamide on the skeletal system in rats. The experiments were carried out in male Wistar rats with initial body weight of 212-229 g, divided into 3 groups (n = 6): I--Control, II--Cyclophosphamide (10 mg/kg m.c. i.m. daily for 14 days, and after a 7-day break, for 7 days), III--Cyclophosphamide (20 mg/kg m.c.p.o. daily for the initial 14 days). After 30 days of the experiment, the animals were killed and bone mass, length and diameter of long bones, mineral content in bones, transverse cross-section surfaces of the cortical diaphysis and of the marrow cavity, transverse growth, width of endosteal and periosteal osteoid in the tibia, width of trabeculae, width of epiphyseal cartilage and mechanical features of the femur were examined. Cyclophosphamide caused disorders of bone tissue remodeling. Decreases in bone mass, length, diameter, mineral content in bones, width of trabeculae in the femur, transverse growth, width of osteoid, transverse cross-section surface of the cortical diaphysis, and worsening of mechanical properties of the femur were observed.