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1.
Cyberpsychol Behav Soc Netw ; 26(5): 338-345, 2023 May.
Artigo em Inglês | MEDLINE | ID: mdl-36897292

RESUMO

Since the breakout of COVID-19 in late 2019, various conspiracy theories have spread widely on social media and other channels, fueling misinformation about the origins of COVID-19 and the motives of those working to combat it. This study analyzes tweets (N = 313,088) collected over a 9-month period in 2020, which mention a set of well-known conspiracy theories about the role of Bill Gates during the pandemic. Using a topic modeling technique (i.e., Biterm Topic Model), this study identified ten salient topics surrounding Bill Gates on Twitter, and we further investigated the interactions between different topics using Granger causality tests. The results demonstrate that emotionally charged conspiratorial narratives are more likely to breed other conspiratorial narratives in the following days. The findings show that each conspiracy theory is not isolated by itself. Instead, they are highly dynamic and interwoven. This study presents new empirical insights into how conspiracy theories spread and interact during crises. Practical and theoretical implications are also discussed.


Assuntos
COVID-19 , Mídias Sociais , Humanos , Pandemias , Narração , Motivação
2.
Folia Morphol (Warsz) ; 82(2): 346-358, 2023.
Artigo em Inglês | MEDLINE | ID: mdl-35285510

RESUMO

BACKGROUND: The aim of this study was to assess whether the difference in dental ages between 2009 to 2011 and 2021 is affected by environmental factors such as environmental pollution, floating population, and dietary habits. MATERIALS AND METHODS: Demirjian and Willems dental age estimation methods were conducted for a Han population of children aged 8 to 14 in Shanghai, China. A total of 1259 digital panoramic radiographs of children aged 8.00-14.99 were estimated. All digital panoramic radiographs were estimated using the Demirjian and Willems methods. Data collected in 2009 to 2011 and 2021 were statistically analysed by paired t-tests. RESULTS: The results show that the Demirjian method overestimates 2009 to 2011 and underestimates 2021 the children's chronological age. When using the Willems method, the age of males was overestimated and the age of females was underestimated from 2009 to 2011, and it was underestimated for both genders in 2021. CONCLUSIONS: In conclusion, the difference in dental ages between 2009 to 2011 and 2021 was statistically significant. Factors such as environment and dietary habits have been found to be affected by dental development. However, there are disputes among some researchers about the exact factors, so it is suggested to further study the effects of environmental factors on tooth development.


Assuntos
Determinação da Idade pelos Dentes , Dente , Criança , Humanos , Masculino , Feminino , Adolescente , Determinação da Idade pelos Dentes/métodos , Radiografia Panorâmica/métodos , China , Dente/diagnóstico por imagem
3.
Phys Rev Lett ; 127(11): 113001, 2021 Sep 10.
Artigo em Inglês | MEDLINE | ID: mdl-34558915

RESUMO

We observe experimentally the spontaneous formation of star-shaped surface patterns in driven Bose-Einstein condensates. Two-dimensional star-shaped patterns with l-fold symmetry, ranging from quadrupole (l=2) to heptagon modes (l=7), are parametrically excited by modulating the scattering length near the Feshbach resonance. An effective Mathieu equation and Floquet analysis are utilized, relating the instability conditions to the dispersion of the surface modes in a trapped superfluid. Identifying the resonant frequencies of the patterns, we precisely measure the dispersion relation of the collective excitations. The oscillation amplitude of the surface excitations increases exponentially during the modulation. We find that only the l=6 mode is unstable due to its emergent coupling with the dipole motion of the cloud. Our experimental results are in excellent agreement with the mean-field framework. Our work opens a new pathway for generating higher-lying collective excitations with applications, such as the probing of exotic properties of quantum fluids and providing a generation mechanism of quantum turbulence.

4.
Am Behav Sci ; 65(12): 1608-1622, 2021 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-38602993

RESUMO

The tsunami of change triggered by the COVID-19 pandemic has transformed society in a series of cascading crises. Unlike disasters that are more temporarily and spatially bounded, the pandemic has continued to expand across time and space for over a year, leaving an unusually broad range of second-order and third-order harms in its wake. Globally, the unusual conditions of the pandemic-unlike other crises-have impacted almost every facet of our lives. The pandemic has deepened existing inequalities and created new vulnerabilities related to social isolation, incarceration, involuntary exclusion from the labor market, diminished economic opportunity, life-and-death risk in the workplace, and a host of emergent digital, emotional, and economic divides. In tandem, many less advantaged individuals and groups have suffered disproportionate hardship related to the pandemic in the form of fear and anxiety, exposure to misinformation, and the effects of the politicization of the crisis. Many of these phenomena will have a long tail that we are only beginning to understand. Nonetheless, the research also offers evidence of resilience on several fronts including nimble organizational response, emergent communication practices, spontaneous solidarity, and the power of hope. While we do not know what the post COVID-19 world will look like, the scholarship here tells us that the virus has not exhausted society's adaptive potential.

5.
Am Behav Sci ; 65(12): 1603-1607, 2021 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-38603108

RESUMO

This collection sheds light on the cascading crises engendered by COVID-19 on many aspects of society from the economic to the digital. This issue of the American Behavioral Scientist brings together scholarship examining the various ways in which many vulnerable populations are bearing a disproportionate share of the costs of COVID-19. As the articles bring to light, the unequal effects of the pandemic are reverberating along preexisting fault lines and creating new ones. In the economic realm, the rental market emerges during the pandemic as an economic arena of heightened socio-spatial and racial/ethnic disparities. Financial markets are another domain where market mechanisms mask the exploitative relationships between the economically vulnerable and powerful actors. Turning to gender inequalities, across national contexts, women represent an increasingly vulnerable segment of the labor market as the pandemic piles on new burdens of remote schooling and caregiving despite a variety of policy initiatives. Moving from the economic to the digital domain, we see how people with disabilities employ social media to mitigate increased vulnerability stemming from COVID-19. Finally, the key effects of digital vulnerability are heightened because the digitally disadvantaged experience not only informational inequalities but also aggravated bodily manifestations of stress or anxiety related to the pandemic. Each article contributes to our understanding of the larger mosaic of inequality that is being exacerbated by the pandemic. By drawing connections between these different aspects of the social world and the effects of COVID-19, this issue of American Behavioral Scientist advances our understanding of the far-reaching ramifications of the pandemic on vulnerable members of society.

6.
Am Behav Sci ; 65(14): 2014-2036, 2021 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-38603026

RESUMO

Although studies have investigated cyber-rumoring previous to the pandemic, little research has been undertaken to study rumors and rumor-corrections during the COVID-19 (coronavirus disease 2019) pandemic. Drawing on prior studies about how online stories become viral, this study will fill that gap by investigating the retransmission of COVID-19 rumors and corrective messages on Sina Weibo, the largest and most popular microblogging site in China. This study examines the impact of rumor types, content attributes (including frames, emotion, and rationality), and source characteristics (including follower size and source identity) to show how they affect the likelihood of a COVID-19 rumor and its correction being shared. By exploring the retransmission of rumors and their corrections in Chinese social media, this study will not only advance scholarly understanding but also reveal how corrective messages can be crafted to debunk cyber-rumors in particular cultural contexts.

7.
Folia Morphol (Warsz) ; 79(4): 851-859, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-31930465

RESUMO

BACKGROUND: The aim of this study was to investigate the association between chronological age and the pulp/tooth volume ratio (PTR) of specific teeth using cone-beam computed tomography (CBCT) enhanced with Materialise-Mimics Research software 21.0 in children and young adult population from Eastern China. MATERIALS AND METHODS: CBCT scans of 230 patients (119 males, 111 females), aged 8.18-19.92 years were analysed by two well-trained examiners in this retrospective study. The intraclass correlation coefficient value was calculated to test the intra- and inter-examiner agreement. The volumetric analysis of the pulp and calcified tissues was performed on the maxillary left central incisors and canines. The correlation and regression analyses were then performed. RESULTS: The Pearson correlation analysis showed a strong coefficient of correlation (r) for maxillary left canines (-0.81 for girls and -0.88 for boys) as compared to central incisors (-0.63 for girls and -0.70 for boys). Regarding performance, the canine model was more powerful than the central incisor model. The derived regression equation from maxillary left canines had high coefficients of determination (Age = 21.979 - 105.42 × PTR, R2 = 0.69). CONCLUSIONS: Our study proved that the PTR value of canines had a negative correlation relationship with a subadult's chronological age and volumetric analysis of CBCT scans using the software may become an efficient method to estimate the chronological age of children and young adults.


Assuntos
Determinação da Idade pelos Dentes , Adulto , Idoso , Idoso de 80 Anos ou mais , Criança , Tomografia Computadorizada de Feixe Cônico , Dente Canino/diagnóstico por imagem , Feminino , Humanos , Incisivo/diagnóstico por imagem , Masculino , Maxila/diagnóstico por imagem , Pessoa de Meia-Idade , Estudos Retrospectivos , Adulto Jovem
8.
Biomaterials ; 233: 119591, 2020 03.
Artigo em Inglês | MEDLINE | ID: mdl-31870566

RESUMO

Human insulin-like growth factor-1 (IGF-1) plays important roles in development and regeneration of skeletal muscles and bones but requires daily injections or surgical implantation. Current clinical IGF-1 lacks e-peptide and is glycosylated, reducing functional efficacy. In this study, codon-optimized Pro-IGF-1 with e-peptide (fused to GM1 receptor binding protein CTB or cell penetrating peptide PTD) was expressed in lettuce chloroplasts to facilitate oral delivery. Pro-IGF-1 was expressed at high levels in the absence of the antibiotic resistance gene in lettuce chloroplasts and was maintained in subsequent generations. In lyophilized plant cells, Pro-IGF-1 maintained folding, assembly, stability and functionality up to 31 months, when stored at ambient temperature. CTB-Pro-IGF-1 stimulated proliferation of human oral keratinocytes, gingiva-derived mesenchymal stromal cells and mouse osteoblasts in a dose-dependent manner and promoted osteoblast differentiation through upregulation of ALP, OSX and RUNX2 genes. Mice orally gavaged with the lyophilized plant cells significantly increased IGF-1 levels in sera, skeletal muscles and was stable for several hours. When bioencapsulated CTB-Pro-IGF-1 was gavaged to femoral fractured diabetic mice, bone regeneration was significantly promoted with increase in bone volume, density and area. This novel delivery system should increase affordability and patient compliance, especially for treatment of musculoskeletal diseases.


Assuntos
Diabetes Mellitus Experimental , Consolidação da Fratura , Fraturas Ósseas/tratamento farmacológico , Fator de Crescimento Insulin-Like I/administração & dosagem , Lactuca , Administração Oral , Animais , Diferenciação Celular , Proliferação de Células , Células Cultivadas , Humanos , Camundongos , Osteoblastos
9.
J Hosp Infect ; 103(3): 276-279, 2019 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-31319094

RESUMO

Since 2011, 2% chlorhexidine in 70% isopropyl alcohol (2% chlorhexidine tincture) has been widely used in Korea. To investigate changes in chlorhexidine sensitivity of staphylococci causing central line-associated bloodstream infections, 264 blood culture isolates from adult patients treated in intensive care units of five university hospitals between 2008 and 2016 were analysed. We observed no significant changes in chlorhexidine minimum inhibitory and bactericidal concentrations, or in the prevalence of resistance-associated genes before and after introduction of 2% chlorhexidine tincture. Thus, there was no evidence of increased resistance to chlorhexidine in staphylococci causing central line-associated bloodstream infections.


Assuntos
Bacteriemia/microbiologia , Infecções Relacionadas a Cateter/microbiologia , Clorexidina/farmacologia , Desinfetantes/farmacologia , Infecções Estafilocócicas/microbiologia , Staphylococcus/efeitos dos fármacos , Adulto , Idoso , Idoso de 80 Anos ou mais , Cateterismo Venoso Central/efeitos adversos , Feminino , Humanos , Unidades de Terapia Intensiva , Coreia (Geográfico) , Masculino , Testes de Sensibilidade Microbiana , Pessoa de Meia-Idade , Staphylococcus/isolamento & purificação
10.
Folia Morphol (Warsz) ; 78(4): 833-838, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-30835339

RESUMO

BACKGROUND: In physical anthropology, bone landmarks are palpated in living humans for the identification of corresponding skin landmarks and exact biometry. The purpose of this study is to help comprehend the locations and depths of representative bone landmarks all over the body. MATERIALS AND METHODS: The sectioned images of a male cadaver's whole body were used to build a volume model, which was continuously peeled at 1 mm thicknesses to disclose 27 selected landmarks in the anterior, lateral, or posterior views. RESULTS: The captured views of peeled volume models along with the labels of the bone landmarks were loaded to browsing software that was distributed for free. The browsing software containing the peeled volume models will enhance convenient studying of the bone landmarks. CONCLUSIONS: With the knowledge of bone landmarks, investigators would be able to attain more accurate measurements between skin landmarks.


Assuntos
Pontos de Referência Anatômicos , Antropologia , Modelos Anatômicos , Adulto , Extremidades/anatomia & histologia , Humanos , Masculino , Software
11.
Clin Microbiol Infect ; 25(6): 723-732, 2019 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-30287412

RESUMO

OBJECTIVES: To assess the outcome of Staphylococcus aureus bacteraemia (SAB) according to factors associated with necessity for longer treatment in conjunction with the duration of treatment. METHODS: We prospectively collected the data of patients with SAB consecutively during 12 to 39 months from 11 hospitals. If multiple episodes of SAB occurred in one patient, only the first episode was enrolled. Factors associated with necessity for longer treatment were defined as follows: persistent bacteraemia, metastatic infection, prosthesis and endocarditis. If any of the factors were present, then the case was defined as longer antibiotic treatment warranted (LW) group; those without any factors were defined as shorter antibiotic treatment sufficient (SS) group. Poor outcome was defined as a composite of 90-day mortality or 30-day recurrence. Duration of antibiotic administration was classified as <14 or ≥14 days in the SS group and <28 or ≥28 days in the LW group. RESULTS: Among 2098 cases, the outcome was analysed in 1866 cases, of which 591 showed poor outcome. The SS group accounted for 964 cases and the LW group for 852. On multivariate analysis, age over 65 years, pneumonia, higher Sequential Organ Failure Assessment (SOFA) score and chronic liver diseases were risk factors for poor outcome. Administration of antibiotics less than the recommendation was associated with poor outcome, but this significance was observed only in the LW group (adjusted odds ratio = 1.68; 95% confidence interval, 1.00-2.83; p 0.05). CONCLUSIONS: Inappropriately short antibiotic treatment was associated with poor outcome in the LW group. Vigilant evaluation for risk factors to determine the duration of treatment may improve the outcome among patients with SAB.


Assuntos
Anti-Infecciosos/administração & dosagem , Bacteriemia/tratamento farmacológico , Infecções Estafilocócicas/tratamento farmacológico , Staphylococcus aureus/efeitos dos fármacos , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Bacteriemia/mortalidade , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Prospectivos , Recidiva , Infecções Estafilocócicas/mortalidade , Análise de Sobrevida , Fatores de Tempo , Resultado do Tratamento , Adulto Jovem
12.
Transplant Proc ; 50(10): 3222-3227, 2018 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-30577189

RESUMO

PURPOSE: The use of expanded-criteria deceased-donor (ECD) kidneys must be evaluated within the objective perspective of critical organ shortage and graft function and survival. In this study, we aimed to compare the clinical outcomes of ECD reliance with concurrent use of ideal-criteria deceased donors (IDDs) and non-ECDs in adult renal transplantation. METHODS: Between February 2000 and December 2015, we analyzed 405 deceased-donor renal transplants, specifically 129 grafts (31.9%) from ECDs, 233 grafts (57.5%) from non-ECDs, and 43 grafts (10.6%) from IDDs. ECDs were classified according to the United Network for Organ Sharing guidelines, while an IDD was defined as a younger person (10-39 years of age) with no medical risk factors who died from a traumatic head injury. Donor and recipient risk factors were separately analyzed and correlated with recipient graft function, and survival was evaluated. RESULTS: ECDs were older (56.8 ± 6.3 years); showed increased incidence of hypertension, diabetes, and cerebrovascular brain death; and had a higher pre-retrieval serum creatinine level than the other groups. ECD kidney recipients were also older (50.6 ± 9.8 years), had a shorter waiting time (P = .031), and demonstrated a low frequency of re-transplantation (P = .028). Long-term renal function followed longitudinally was lower in ECD kidney recipients until five years after transplantation, while the glomerular filtration rate (GFR) level at 7 and 10 years did not differ significantly among the groups (P = .074 and .262, respectively). There were no significant differences in terms of graft survival (P = .394) or patient survival (P = .737) among the groups. CONCLUSIONS: Although the long-term renal function followed longitudinally was lower in ECD kidney recipients, the use of renal grafts from ECDs is an acceptable method to resolve the disparity of critical organ shortage. However, the classification of the high-risk group should be updated with consideration given to differences in regional characteristics.


Assuntos
Transplante de Rim/métodos , Doadores de Tecidos/classificação , Doadores de Tecidos/provisão & distribuição , Adolescente , Adulto , Criança , Feminino , Sobrevivência de Enxerto , Humanos , Rim/fisiopatologia , Transplante de Rim/mortalidade , Masculino , Pessoa de Meia-Idade , Estudos Retrospectivos , Fatores de Risco , Resultado do Tratamento , Adulto Jovem
13.
Eur J Trauma Emerg Surg ; 44(3): 443-449, 2018 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-28656387

RESUMO

PURPOSE: We investigated the spontaneous recovery of non-operated traumatic brachial plexus injury (BPI). METHODS: A total of 25 cases of non-operated traumatic BPI were analysed by retrospective review of medical records; in all cases, consecutive electrodiagnostic studies (ES) were conducted from 1 to 4 months and 18 to 24 months post-trauma. Injury severity was assessed using a modified version of Dumitru and Wilbourn's scale (DWS) based on ES. Spontaneous recovery of brachial plexus components per subject was analysed using Wilcoxon's signed-rank test. A two-tailed Fisher's exact or Pearson's Chi-square test was used to examine the associations between initial injury severity (DWS grade 2 vs. 3, complete vs. incomplete), accompanying injury type (open vs. closed), main lesion location (supraclavicular vs. infraclavicular lesion), and spontaneous recovery. RESULTS: The most common cause of BPI was traffic accident (TA) (15 cases, 60%), and the most common type of TA-induced BPI was a motorcycle TA (5 cases), accounting for 20% of all injuries. The second most common type of injury was an occupational injury (6 cases, 24%). Thirty-eight (69%) of 55 injured brachial components in 25 cases had DWS grade 3 and 17 brachial components (31%) had grade 2. The DWS grade of brachial plexus components per subject significantly differed between the first and follow-up ES (p = 0.000). However, initial injury severity, accompanying injury type, and main lesion location were not statistically associated with spontaneous recovery (p > 0.05). CONCLUSIONS: Spontaneous recovery may be possible even in severe traumatic BPI. Multiple factors should be considered when predicting the clinical course of traumatic BPI.


Assuntos
Plexo Braquial/lesões , Remissão Espontânea , Eletrodiagnóstico , Feminino , Humanos , Escala de Gravidade do Ferimento , Masculino , Pessoa de Meia-Idade , Prognóstico , Estudos Retrospectivos
14.
Eur J Clin Microbiol Infect Dis ; 36(11): 2187-2191, 2017 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-28639163

RESUMO

Methicillin-resistant Staphylococcus aureus bacteremia (MRSAB) often persists despite appropriate antibiotic therapy. It is unclear what microbiological factors contribute to poor clinical outcomes in persistent MRSAB (pMRSAB). We aimed to identify clinical and microbiological risk factors for in-hospital mortality in pMRSAB. We analysed MRSAB cases prospectively collected between 2009 and 2016 at 11 hospitals in Korea, defining cases of pMRSAB as MRSAB lasting ≥5 days despite administration of effective antibiotics. The first blood isolates from the pMRSAB cases were tested for staphylococcal cassette chromosome mec type, staphylococcal protein A type, accessary gene regulator (agr) type, genes for Panton-Valentine leukocidin and phenol-soluble modulin-mec, vancomycin minimum inhibitory concentration, vancomycin heteroresistance, and agr functionality. We also collected clinical information for each case. Of 960 MRSAB cases, 152 pMRSAB were finally eligible. Univariable analysis revealed that in-hospital mortality was significantly associated with Charlson's comorbidity-weighted index (CCWI) score, Pitt bacteremia score, sequential organ failure assessment score, presentation with septic shock, pneumonia, agr dysfunction, and vancomycin heteroresistance. Bone and joint infections were negatively associated with in-hospital mortality. Multivariable analysis revealed the following independent risk factors for in-hospital mortality: CCWI score [adjusted odds ratio (aOR), per one point, 1.25; 95% confidence interval (CI), 1.08-1.44; P = 0.003), Pitt bacteremia score (aOR, per one point, 1.33; 95% CI, 1.09-1.62; P = 0.005), non-eradicated foci of infection (aOR, 3.12; 95% CI, 1.18-8.27; P = 0.022), and agr dysfunction (aOR, 2.48; 95% CI, 1.12-5.47; P = 0.025). agr dysfunction is an independent risk factor for in-hospital mortality in pMRSAB.


Assuntos
Bacteriemia/tratamento farmacológico , Bacteriemia/mortalidade , Proteínas de Bactérias/genética , Staphylococcus aureus Resistente à Meticilina/genética , Infecções Estafilocócicas/tratamento farmacológico , Infecções Estafilocócicas/mortalidade , Transativadores/genética , Idoso , Antibacterianos/uso terapêutico , Bacteriemia/microbiologia , Toxinas Bacterianas/genética , Exotoxinas/genética , Feminino , Mortalidade Hospitalar , Humanos , Sequências Repetitivas Dispersas/genética , Leucocidinas/genética , Masculino , Staphylococcus aureus Resistente à Meticilina/isolamento & purificação , Testes de Sensibilidade Microbiana , Pessoa de Meia-Idade , Fatores de Risco , Infecções Estafilocócicas/microbiologia , Proteína Estafilocócica A/genética , Resultado do Tratamento , Resistência a Vancomicina/genética
15.
J Physiol Pharmacol ; 68(1): 69-77, 2017 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-28456771

RESUMO

Small bowel injury can occur as the result of a multifaceted process that includes increased acid secretion, generation of reactive oxygen species, and cyclooxygenase inhibition. However, no effective medication for small bowel ulceration is available. Simvastatin is an important lipid-lowering agent with anti-inflammatory activity. We aimed to validate the effects of simvastatin in vitro and in vivo. In presence or absence of simvastatin, IEC-6 small bowel cell line with 50 ng/ml of tumor nectosis factor α (TNF-α) was investigated by western blotting, qRT-PCR, and DCF-DA assay. In addition, an in vivo study of nonsteroidal anti-inflammatory drugs (NSAID)-induced small bowel inflammation was performed using 7-week-old specific-pathogen-free (SPF) male C57BL/6 mice. Simvastatin treatment reduced the mRNA levels of interleukin-6 and interleukin-8 by approximately 50% in TNF-α-stimulated IEC-6 cells. Treatment with a combination of 50 ng/ml TNF-α and µM simvastatin decreased activation of Akt, IκBα, and nuclear factor-κB p65 level in IEC-6 cells. By DCF-DA staining, intracellular reactive oxygen species (ROS) production was increased in TNF-α-stimulated cells, and treatment with simvastatin decreased the level of ROS. In addition, in vivo mouse model of NSAID-induced small bowel inflammation, the administration of simvastatin reduced the number of small bowel hemorrhagic lesions and the level of ROS production as determined by gross examination and 8-hydroxydeoxyguanosine immunohistochemistry of small bowel tissue, respectively. Simvastatin reduced NSAID-induced injuries by both suppression of ROS generation and modulation of inflammatory cytokines in vitro and in vivo. Therefore, simvastatin, an HMG-CoA reductase inhibitor, has potential as a prophylactic and therapeutic agent for NSAID-induced small bowel injury.


Assuntos
Anti-Inflamatórios/efeitos adversos , Anti-Inflamatórios/uso terapêutico , Inibidores de Hidroximetilglutaril-CoA Redutases/uso terapêutico , Indometacina/efeitos adversos , Enteropatias/tratamento farmacológico , Intestino Delgado/lesões , Sinvastatina/uso terapêutico , 8-Hidroxi-2'-Desoxiguanosina , Animais , Linhagem Celular , Ciclo-Oxigenase 1/genética , Ciclo-Oxigenase 2/genética , Desoxiguanosina/análogos & derivados , Desoxiguanosina/metabolismo , Inibidores de Hidroximetilglutaril-CoA Redutases/farmacologia , Interleucina-6/metabolismo , Interleucina-8/metabolismo , Enteropatias/induzido quimicamente , Enteropatias/metabolismo , Enteropatias/patologia , Intestino Delgado/metabolismo , Intestino Delgado/patologia , Masculino , Proteínas de Membrana/genética , Camundongos Endogâmicos C57BL , Inibidor de NF-kappaB alfa/metabolismo , Ratos , Espécies Reativas de Oxigênio/metabolismo , Sinvastatina/farmacologia , Fator de Necrose Tumoral alfa/metabolismo , Fator de Necrose Tumoral alfa/farmacologia
16.
Neuroscience ; 301: 403-14, 2015 Aug 20.
Artigo em Inglês | MEDLINE | ID: mdl-26047724

RESUMO

While prolonged sleep deprivation (SD) could lead to profound negative health consequences, such as impairments in vital biological functions of immunity and cognition, melatonin possesses powerful ameliorating effects against those harmful insults. Melatonin has strong antioxidant and anti-inflammatory effects that help to restore body's immune and cognitive functions. In this study, we investigated the possible role of melatonin in reversing cognitive dysfunction induced by SD in rats. Our experimental results revealed that sleep-deprived animals exhibited spatial memory impairment in the Morris water maze tasks compared with the control groups. Furthermore, there was an increased glial activation most prominent in the hippocampal region of the SD group compared to the normal control (NC) group. Additionally, markers of oxidative stress such as 4-hydroxynonenal (4-HNE) and 7,8-dihydro-8-oxo-deoxyguanine (8-oxo-dG) were significantly increased, while fragile X-mental retardation protein (FMRP) expression was decreased in the SD group. Interestingly, melatonin treatment normalized these events to control levels following SD. Our data demonstrate that SD induces oxidative stress through glial activation and decreases FMRP expression in the neurons. Furthermore, our results suggest the efficacy of melatonin for the treatment of sleep-related neuronal dysfunction, which occurs in neurological disorders such as Alzheimer's disease and autism.


Assuntos
Antioxidantes/uso terapêutico , Proteína do X Frágil da Deficiência Intelectual/metabolismo , Melatonina/uso terapêutico , Transtornos da Memória/etiologia , Transtornos da Memória/prevenção & controle , Privação do Sono/complicações , 8-Hidroxi-2'-Desoxiguanosina , Aldeídos/metabolismo , Animais , Encéfalo/efeitos dos fármacos , Encéfalo/metabolismo , Sobrevivência Celular/genética , Células Cultivadas , Córtex Cerebral/citologia , Desoxiguanosina/análogos & derivados , Desoxiguanosina/metabolismo , Modelos Animais de Doenças , Embrião de Mamíferos , Proteína do X Frágil da Deficiência Intelectual/genética , Regulação da Expressão Gênica/efeitos dos fármacos , Regulação da Expressão Gênica/genética , Masculino , Aprendizagem em Labirinto/efeitos dos fármacos , Neurônios/efeitos dos fármacos , Neurônios/metabolismo , RNA Interferente Pequeno/genética , RNA Interferente Pequeno/metabolismo , Ratos , Ratos Sprague-Dawley , Ratos Wistar , Espécies Reativas de Oxigênio/metabolismo
17.
J Vet Pharmacol Ther ; 38(6): 590-5, 2015 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-25955782

RESUMO

The objective of this study was to describe the population pharmacokinetics (PK) of mosapride under fasting and fed conditions. A single 5-mg oral dose of mosapride was administered to fasted (n = 15) and fed (n = 12) beagle dogs. Plasma concentrations of mosapride were subsequently measured by liquid chromatography-tandem mass spectrometry. Data were analyzed using modeling approaches with the NONMEM 7.2 software. A one-compartment open PK model utilizing model event time (MTIME) with first-order absorption and first-order elimination was found to be more appropriate than all other PK models tested. The absorption rate constants of mosapride were significantly decreased under fed conditions, compared to fasting conditions. The observed bootstrap medians of PK parameters were generally consistent with the corresponding population mean estimates. Furthermore, with the exception of some mosapride concentrations, most of observed data fell into the range of the 5th and 95th percentiles of the simulated values. Overall, the final model was able to describe the observed mosapride concentrations reasonably well. These findings suggest that food intake affects both the rate and extent of absorption of mosapride and that the pharmacological effect of mosapride can differ significantly depending on food intake.


Assuntos
Benzamidas/farmacocinética , Ingestão de Alimentos , Morfolinas/farmacocinética , Agonistas do Receptor de Serotonina/farmacocinética , Administração Oral , Animais , Benzamidas/administração & dosagem , Benzamidas/sangue , Cromatografia Líquida , Cães , Jejum , Masculino , Modelos Biológicos , Morfolinas/administração & dosagem , Morfolinas/sangue , Agonistas do Receptor de Serotonina/administração & dosagem , Agonistas do Receptor de Serotonina/sangue , Espectrometria de Massas em Tandem
18.
Eur J Clin Microbiol Infect Dis ; 34(7): 1395-401, 2015 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-25828065

RESUMO

It is uncertain whether an initial inappropriate empirical antibiotic treatment of coagulase-negative staphylococci (CoNS) bacteremia adversely affects the outcome. A retrospective cohort study of CoNS bacteremia was performed at the Dongguk University Ilsan Hospital during a 3-year period. During the study period, 109 patients with CoNS bacteremia were enrolled. The median age of the patients was 72 years and most (96%, 105/109) had one or more comorbid diseases. Among the participants, 29% (32/109) received an appropriate empirical antimicrobial therapy. The 30-day mortality was 24% (26/109) and CoNS bacteremia-related mortality was 14% (15/109). There was no difference in the CoNS bacteremia-related mortality between the group with an inappropriate empirical treatment (13%, 10/77) and that with an appropriate treatment (16%, 5/32) (p = 0.46). In the multivariate analysis using the Cox regression analysis method, Pitt bacteremia scores [hazard ratio (HR) 1.48; 95% confidence interval (CI) 1.09-2.01; p = 0.01] and retention of eradicable focus (HR 5.0; 95% CI 1.39-17.9; p = 0.01) were found to be associated with CoNS bacteremia-related mortality. The results suggest that inappropriate empirical therapy might not necessarily be associated with the 30-day mortality or CoNS bacteremia-related mortality. Conversely, Pitt bacteremia scores and retention of eradicable focus were associated with poor outcomes.


Assuntos
Bacteriemia , Coagulase/deficiência , Infecções Estafilocócicas/epidemiologia , Infecções Estafilocócicas/microbiologia , Staphylococcus/classificação , Idoso , Anti-Infecciosos/uso terapêutico , Infecções Relacionadas a Cateter/tratamento farmacológico , Infecções Relacionadas a Cateter/epidemiologia , Infecções Relacionadas a Cateter/microbiologia , Comorbidade , Feminino , Hospitais Universitários , Humanos , Masculino , Resistência a Meticilina , Pessoa de Meia-Idade , Mortalidade , Estudos Retrospectivos , Fatores de Risco , Infecções Estafilocócicas/tratamento farmacológico , Staphylococcus/isolamento & purificação , Resultado do Tratamento
19.
Clin Pharmacol Ther ; 98(1): 96-106, 2015 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-25786663

RESUMO

We retrospectively investigated whether palonosetron administered during the induction of general anesthesia is associated with an increased risk of perioperative cardiovascular complications in a single tertiary center cohort consisting of 4,517 palonosetron-exposed patients and 4,517 propensity score-matched patients without palonosetron exposure. The primary endpoint was a composite of perioperative cardiovascular complications, including intraoperative cardiac arrhythmia, intraoperative cardiac death, and myocardial injury within the first postoperative week, and there was no significant difference between the groups (odds ratio [OR] = 1.04; 95% confidence interval [CI] = 0.92-1.19). As secondary endpoints, intraoperative cardioversion, cardiac compression, use of cardiovascular drugs, postoperative hospital stay, and in-hospital mortality showed no differences between the groups. However, the palonosetron group showed decreased intraoperative hypotension (OR = 0.88; 95% CI = 0.79-0.97) and length of postoperative intensive care unit (ICU) stay (4.26 ± 9.86 vs. 6.14 ± 16.75; P = 0.026). Palonosetron did not increase the rate of perioperative cardiovascular complications, and can therefore be used safely during anesthetic induction.


Assuntos
Anestesia Geral , Antieméticos/efeitos adversos , Sistema Cardiovascular/efeitos dos fármacos , Isoquinolinas/efeitos adversos , Quinuclidinas/efeitos adversos , Antagonistas do Receptor 5-HT3 de Serotonina/efeitos adversos , Adulto , Idoso , Arritmias Cardíacas/induzido quimicamente , Estudos de Casos e Controles , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Infarto do Miocárdio/induzido quimicamente , Palonossetrom , Período Perioperatório , Estudos Retrospectivos
20.
Cyberpsychol Behav Soc Netw ; 18(2): 93-100, 2015 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-25684610

RESUMO

Badge systems, a common mechanism for gamification on social media platforms, provide a way for users to present their knowledge or experience to others. This study aims to contribute to the understanding of why social media users publicize their achievements in the form of online badges. Five motivational factors for badge display in public networked environments are distinguished-self-efficacy, social incentives, networked support, passing time, and inattentive sharing-and it is suggested that different badge types are associated with different motivations. System developers are advised to consider these components in their designs, applying the elements most appropriate to the communities they serve. Comparing user motivations associated with badges shared across boundaries provides a better understanding of how online badges relate to the larger social media ecosystem.


Assuntos
Logro , Internet , Motivação , Autoeficácia , Mídias Sociais , Adulto , Feminino , Humanos , Masculino
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