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Bioorg Med Chem Lett
; 20(18): 5488-90, 2010 Sep 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-20692833
RESUMO
The serendipitous discovery of N-cyclohexyl-8-fluoro-3,3a,4,9b-tetrahydro-1H-thiochromeno[4,3-c]isoxazole-1-carboxamide as a selective human serotonin 5-HT2B antagonist with Ki of 42+/-5 nM is reported herein. A subsequent functional assay indicated little agonist activity compared to 5-HT itself.