RESUMO
No abstract available.
Assuntos
Epilepsias Parciais , Cefaleia , Hemianopsia , Transtornos de Enxaqueca , Lobo OccipitalRESUMO
Among 249 patients with teratoma-associated encephalitis, 211 had N-methyl-D-aspartate receptor antibodies and 38 were negative for these antibodies. Whereas antibody-positive patients rarely developed prominent brainstem-cerebellar symptoms, 22 (58%) antibody-negative patients developed a brainstem-cerebellar syndrome, which in 45% occurred with opsoclonus. The median age of these patients was 28.5 years (range = 12-41), 91% were women, and 74% had full recovery after therapy and tumor resection. These findings uncover a novel phenotype of paraneoplastic opsoclonus that until recently was likely considered idiopathic or postinfectious. The triad of young age (teenager to young adult), systemic teratoma, and high response to treatment characterize this novel brainstem-cerebellar syndrome.
Assuntos
Neoplasias do Tronco Encefálico/imunologia , Encefalite/complicações , Encefalite/terapia , Transtornos da Motilidade Ocular/complicações , Teratoma/complicações , Adulto , Autoanticorpos/imunologia , Neoplasias do Tronco Encefálico/complicações , Neoplasias do Tronco Encefálico/cirurgia , Neoplasias Cerebelares/complicações , Neoplasias Cerebelares/imunologia , Neoplasias Cerebelares/cirurgia , Criança , Encefalite/imunologia , Feminino , Humanos , Masculino , Transtornos da Motilidade Ocular/imunologia , Receptores de N-Metil-D-Aspartato/imunologia , Avaliação de Sintomas , Síndrome , Teratoma/imunologia , Teratoma/cirurgiaRESUMO
Limbic encephalitis (LE) is characterized by short-term memory loss, disorientation, agitation, seizures, and histological evidence of mesial temporal lobe inflammation. Leucine-rich, glioma inactivated 1 (LGI1) is the autoantigen associated with limbic encephalitis that was previously attributed to voltage-gated potassium channels. We report herein a 54-year-old female with LGI1-related limbic encephalitis who presented with recurrent episodes of episodic memory impairment, depressive mood, and phantosmia. Her symptoms dramatically improved with steroid therapy.
Assuntos
Feminino , Humanos , Pessoa de Meia-Idade , Anticorpos , Di-Hidroergotamina , Glioma , Inflamação , Encefalite Límbica , Memória Episódica , Memória de Curto Prazo , Canais de Potássio de Abertura Dependente da Tensão da Membrana , Convulsões , Lobo TemporalRESUMO
Anterior cerebral artery (ACA) dissection with simultaneous subarachnoid hemorrhage (SAH) and cerebral infarction is very rare and its treatment continues to be debates. We present a case of simultaneous SAH and cerebral infarction caused by dissection of the ACA that was successfully treated by bypass surgery and an endovascular procedure.