Derrame pericárdico neoplásico infectado por Salmonella enteritidis / Pericardial overflow infected by Salmonell enteritidis

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Fiebre de origen desconocidoy disección aórtica / Fever of unknown origin and aortic dissection

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Thromboangiitis obliterans (Buerger's disease) with intestinal involvement--a case report.

Thromboangiitis obliterans (TAO) or Buerger's disease is a nonatherosclerotic vascular disease of unknown etiology that occurs almost exclusively in young male tobacco users. The involvement of the medium-sized and small arteries and veins leads to ischemic complaints and trophic changes in the limbs. The authors report a case of Buerger's disease in a 29-year-old man, a heavy smoker, affecting the lower limbs and mesenteric vessels.

[Jugular thrombosis and adenocarcinoma of the prostate: a state of hypercoagulability?]. / Trombosis yugular y adenocarcinoma de próstata: estado de hipercoagulabilidad?

The association between cancer and hypercoagulability states is well known. It usually presents as a complication of gastrointestinal tract adenocarcinomas. We present the case of patient diagnosed of prostatic adenocarcinoma who was admitted because of pain and inflammation in the left side of the neck. The ultrasound study showed a jugular vein thrombosis. In the bibliographic review (MEDLINE 1990-1995), we have not found any similar reports Jugular vein thrombosis is a rare complication and usually is secondary to central vein catheter insertion, although it has been also described with ovarian hyperstimulation syndrome, infections, head and neck tumors and rarely in other neoplastic diseases. The physiopathologic process is not well known, although it is known that neoplastic cells interact with the thrombin and plasmin generating systems and that there is also a decrease in coagulation inhibitors, all of which leads to prothrombin activation in the absence of the corresponding increases in thrombin inhibitor complexes.

Clinical significance of splenic tuberculosis in patients infected with human immunodeficiency virus.

To assess the clinical significance of splenic tuberculosis in patients infected with human immunodeficiency virus (HIV) type 1, we compared 20 patients who had splenic tuberculosis with 20 randomly selected, HIV-infected patients with culture-proven tuberculosis for whom splenic involvement had been ruled out by ultrasonography. All of the patients were male prison inmates and intravenous drug users. Statistically significant differences (P < .05) were detected between patients with splenic involvement (median CD4+ cell count, 54/mm3) and those without splenic involvement (median CD4+ cell count, 92/mm3). No specific symptoms suggesting splenic involvement were detected in the patients with splenic tuberculosis. All patients received antituberculous drugs, and none of these patients required splenectomy. The median survival was similar in both groups. Splenic tuberculosis occurs in more-severely immunocompromised HIV-infected patients, the prognosis is generally good, the clinical response to therapy is usually favorable, and splenectomy is rarely necessary.

A longitudinal study of transmission of tuberculosis in a large prison population.

The purpose of this study was to determine the extent of transmission of tuberculosis in a large prison population over an 18-mo period. Restriction-fragment-length polymorphism (RFLP) analysis of isolates of Mycobacterium tuberculosis was performed, using the insertion sequence IS6110 and the plasmid pTBN12. Patients infected with strains having the same fingerprint were grouped in clusters. Medical records were reviewed and movement of inmates among prisons was examined for selected patients. Tuberculosis was diagnosed in 216 inmates (case rate = 2,283 per 100,000 per year). Isolates from 210 (97%) patients were fingerprinted, 155 (74%) were grouped in 25 clusters, and 55 (26%) showed a unique fingerprint. Recent infection was inferred in 62% of these patients. Eighty-four percent (161 of 192) of patients tested were human immunodeficiency virus (HIV)-positive, of whom 121 were in clusters and 40 were not (p = 0.74). Patients in clusters were less adherent with tuberculosis treatment than those not in clusters (p < 0.05), and prison transmission of resistant strains was observed. It is crucial that infection control guidelines be fully implemented in the prison setting to prevent tuberculosis transmission.

[Primary cutaneous cryptococcosis and bacterial pneumonia caused by Pseudomonas aeruginosa in AIDS: clinical case and review of the literature]. / Criptococosis cutánea primaria y neumonía bacteriémica por Pseudomonas aeruginosa en el sida: caso clínico y revisión de la literatura.

BACKGROUND: Clinically symptomatic infection due to Cryptococcus neoformans is found in 5-10% of patients with AIDS. It usually appears as meningitis with or without associated blood stream infection. In the last years, severe Pseudomonas aeruginosa infections in HIV (+) patients, with a high morbidity and mortality, are increasingly reported. MATERIALS AND METHODS: A 27 year-old male HIV (+) patient, with previous opportunistic infections, was referred because of a nodular lesion on his left wrist, with an axillar homolateral lymph node of long-term evolution. Cryptococcus neoformans var. neoformans was isolated in pure culture from the lesion. Disseminated infection or affection of other organs was ruled out. Therapy with intravenous amphotericin B was initiated, but the patient developed an early nosocomial bacteremic pneumonia due to P. aeruginosa with a fatal outcome. A review of the literature about both complications in AIDS is carried out. RESULTS: The fungal clinical picture is compatible with primary cutaneous cryptococcosis that is a rare condition (12 clinical reports until 1993), of which only one case report in an AIDS patient has been described in 1994. Since 1990 severe infections due to P. aeruginosa in HIV(+) patients are increasingly reported, and pneumonias, bacteremias, catheter-related sepsis, urinary tract infections, intraabdominal infections, central nervous system and othorrhinolaryngologic infections have been described in patients with AIDS in the English-language literature. CONCLUSIONS: Primary cutaneous cryptococcosis is another rare form of infection with C. neoformans in patients with AIDS. The increasingly reported cases of severe infections due to P. aeruginosa could have important implications in the therapy of patients with AIDS.

[Resistant tuberculosis in a prison population during 1991-1993]. / Tuberculosis resistente en una población penitenciaria durante el período 1991-1993.

BACKGROUND: To know the prevalence of resistant tuberculosis and the characteristics of the same in the penitentiary medium in the Madrid area (Spain). METHODS: From March 1, 1991 to August 31, 1993 a prospective study was carried out in patients with isolations of Mycobacterium tuberculosis resistant to some of the common antituberculous drugs within the context of tuberculosis in a penitentiary population attended in the Hospital General Penitenciario (Madrid). Demographic, clinical, analytical, and microbiological data were collected as was that on the antituberculous treatment used. The study of sensitivities was performed by the proportions method. RESULTS: Tuberculosis was diagnosed in 275 patients according to strict microbiological criteria (positive Löwenstein culture). The antibiogram was performed in 218 isolations. Twenty strains resistant to some first line antituberculous drug (9%) (confidence interval [CI] p < 0.05:6-14), 9 of which were found to be multiresistant, were detected in 20 patients. Out of the patients in whom the sensitivity of the isolate was known, 173 had not previously undergone antituberculous treatment. Six of these patients were found to be resistant to isoniazide (3.5%) (CI p < 0.05:1.4-7.7) and 2 patients were resistant to rifampicin (1.2%) (CI p < 0.5:0.2-4.5). The other 45 patients had previously undergone antituberculous drugs with 8 isolates presenting resistance to isoniazide and 11 to rifampicin. Eighty-four percent of the patients with resistant tuberculosis and 90% of the sensitive cases were coinfected with HIV infection with the differences not being statistically significant. The HIV positive patients with resistant tuberculosis showed a mean CD4 positive lymphocytes of 0.76 x 10(9)/l (CI p < 0.5:0.028-0.213) and those with sensitive tuberculosis had 0.165 x 10(9)/l (CI p < 0.05:0.133-0.196) (p < 0.01). CONCLUSIONS: Tuberculosis resistant to common antituberculous drugs was detected in a Spanish penitentiary population. The level of the resistance of the isolations of Mycobacterium tuberculosis should be monitored both inside and outside of the penitentiary medium in an attempt to avoid the progression of resistant tuberculosis within the Community.

[Tricuspid endocarditis caused by penicillin-resistant Staphylococcus aureus: 2 cases in parenteral drug addicts]. / Endocarditis tricúspide por Staphylococcus aureus sensible a la penicilina: 2 casos en adictos a drogas por vía parenteral.

BACKGROUND: Staphylococcus aureus is the main causal agent of infectious endocarditis (IE) in intravenous drug addicts (IVDA) with most of the strains, isolated in Spain being resistant to penicillin and sensitive to methycillin, although the latter condition varied in recent years. Two cases of IE caused by S. aureus strains sensitive to penicillin in IVDA are presented. METHODS: All bacteremia episodes diagnosed in the Hospital General Penitenciario (Madrid) over a 33-month period (March 1991 to December 1993) were prospectively studied. Special attention was given to patients diagnosed of IE. Blood cultures were processed according to the usual technique by a non radiometric system. RESULTS: One hundred and four bacteremias were detected with 14 being produced by S. aureus. Ten episodes of the total number of bacteremias fulfilled criteria for IE with 2 being produced by strains of S. aureus sensitive to penicillin (CMI < 0.06 mu/ml). Both patients had coinfection by HIV. The clinical evolution prior to diagnosis was prolonged although clinical and microbiologic cure were achieved with intravenous beta-lactam antibiotics treatment, without complications. CONCLUSIONS: Despite the low incidence of the isolation of Staphylococcus aureus sensitive to penicillin (< 3%) recently observed in Spain, strains producing severe infections, showing patterns of sensitivity such as those found during the preantibiotic era, may still be isolated.

[Pseudo-thrombophlebitis syndrome: diagnostic and therapeutic considerations of 2 cases]. / Síndrome pseudotromboflebítico: consideraciones diagnósticas y terapéuticas a propósito de dos casos.

Pseudo-thrombophlebitic syndrome is a frequent clinical entity but many times insufficiently diagnosed. Described more than a century ago by Baker it is characterized for being clinically undistinguishable from a true thrombophlebitis, being its cause the presence of a synovial cyst in the knee joint (Baker's cyst) which can be complicated or not (breakage or dissection). Diagnosis is easy and is based mainly in echography and arthrography. The anticoagulant therapy used in true thrombophlebitis is contraindicated in this syndrome.

[Gastroenteritis with eosinophilia caused by Giardia lamblia]. / Gastroenteritis con eosinofilia por Giardia lamblia.

A case of gastroenteritis due to Giardia lamblia with severe dehydration and complicated with arterial thrombosis, accompanied by eosinophilia and increased serum IgE levels, is presented. The relationship between Giardia and eosinophilia and allergic manifestations is discussed as well as its pathogenesis.