1.
Biochem Soc Trans
; 33(Pt 6): 1375-7, 2005 Dec.
Artigo
em Inglês
| MEDLINE
| ID: mdl-16246122
RESUMO
The Trx (thioredoxin) and Grx (glutaredoxin) systems control cellular redox potential, keeping a reducing thiol-rich intracellular state, which on generation of reactive oxygen species signals through thiol redox control mechanisms. Here, we give a brief overview of the human Trx and Grx systems. The main part focuses on our current knowledge about mitochondrial Grx2, which facilitates mitochondrial redox homoeostasis during oxidative stress-induced apoptosis.