[Evaluation of Aspergillus niger phytase and phosphate in weaned piglets. 2. Content and gain of fat, energy, ash, Ca and P in the animal body]. / Prüfung von Aspergillus-Niger-Phytase und Futterphosphat an Absetzferkeln. 2. Mitteilung--Gehalt und Ansatz an Eiweiss, Fett, Asche, Ca und P im Tierkörper.

A high phytic acid diet (barley, wheat, soya bean meal, 4 g P/kg diet, of that 2/3 phytate P) without added phytase, with phytase supplement (1000 U/kg diet) or with supplementary phosphate (2.2 g P/kg diet) was examined with 3 x 12 weaned piglets. The three diets contained 8 g Ca/kg. At the end of experiment 6 pigs/group were slaughtered. In animal body (as empty body) the content and gain of ash, P, Ca, protein and fat were detected. P supplementation and supplementary phytase had no effect on dry matter, protein and fat content of animal body. The enzyme but more the supplementary phosphate increased mineralization of skeleton and made the animal body higher in ash, P and Ca content. Piglets without supplementary phytase and P gained 1.1 g P daily. Phytase increased daily P gain by 0.5 g (P < 0.05), the phosphate by 1.4 g (P < 0.001). The daily Ca gain was 1.7; 2.8 and 5.1 g in the different groups. A piglet (body weight 20 kg) with sufficient P and Ca in the diet gains 5 g P and 10 g Ca per kg body weight gain (empty body).

[The effect of thioglycoside-containing feed on the growth, thyroid hormone and thiocyanate status of swine and poultry]. / Einfluss thioglycosidhaltigen Futters auf Wachstum, Schilddrüsenhormon- und Thiocyanatstatus von Schwein und Geflügel.

Feed containing rapeseed meal (RSM) with high glucosinolate content (10 mmol/kg feed) induced a strong increase of thyroid weight in pigs and poultry. Supplementary iodine reduced the antithyroid effect, but, it could not cancel it. Only at a low glucosinolate content (0.7 mmol/kg feed) a normal weight of thyroid was established. As the iodine supplementation increased the serum T4 value increased. The thiocyanate serum level increased irrespective of glucosinolate content of the feed. The urine level was significantly decreased due to lower dietary glucosinolate level. Obviously, the goitrogenic effect of the RSM does not correlate with the increased thiocyanate serum level.

[The effect of the phosphorus supply on the energy metabolism of growing swine]. / Untersuchungen zum Einfluss der Phosphor-Versorgung auf den Energieumsatz wachsender Schweine.

In growing barrows (live weight 17-30 kg) 3 g P/kg DM feed resulted in comparison to 6 g P/kg DM in 8% lower live weight gain. The lower live weight gain had no relation to N- and energy retention. The lower P feeding has only low effect on energy excretion in faeces and urine (1% of gross energy). A submarginal P feeding has no influence on N- and energy metabolism of growing pigs.

[The extraction particles from winter rapeseed with different glucosinolate fractions in swine with regard to the iodine supply. 3. Apparent digestibility of crude nutrients with special regard to the carbohydrate and nitrogen balance]. / Prüfung von Extraktionsschroten aus Winterrapssaat mit unterschiedlichem Glucosinolatanteil an Schweinen unter Berücksichtigung der Iodversorgung. 3. Mitteilung. Scheinbare Verdaulichkeit der Rohnährstoffe unter besonderer Berücksichtigung der Kohlenhydrate und N-Bilanz.

In two digestibility and N-balance experiments the following solvent extracted meals were examined in a grain (barley and wheat in equal parts) or in a starch diet with four female pigs/group fitted with urethra catheters during the 5 days sampling period: 48% soyabean meal (SBM) (1), 24% conventional rapeseed meal (RSM) (2), 24 (3) or 48% (4) RSM from a newly bred low glucosinolate variety, groups 1 to 4 with grain, 48% low glucosinolate RSM (5) or 48% SBM (6) both with starch. In numeric order of the groups 88, 85, 86, 84, 79 and 89% N were digested. Pigs responded to the additional faecal N excretion from RSM diets by a lower urinary N excretion and thus they reached the N-balance of the animals fed on SBM. In numeric order of the groups 86, 79, 80, 73, 73 and 92% of the organic matter of the solvent extracted meals were digested. In comparison with SBM even 48% RSM in the feed significantly lowered the digestibility of organic matter. Using detergents the additional faecal organic matter excretion of RSM versus SBM could quantified as two third lignin. In the case of 24% RSM in the diet--i.e. 15% of the carbohydrates given--the carbohydrate digestibility is estimated with a high error, that an energetic feed value should not calculated. Investigating 48% SBM or RSM respectively in a grain diet the net energy content was 9.8 MJ (666 Energetic Feed Units, EFU pig) or 8.3 MJ (569 EFU pig)/kg dry matter (DM). Based on the starch diet, however, little relevant for estimation of normal pig diets, there were evaluated 10.6 MJ (720 EFU pig) for SBM and 8.3 MJ (567 EFU pig) net energy/kg DM for RSM.

[Testing of extracted particles from winter rapeseed with different glucosinolate levels in swine with special reference to the iodine supply. 2. Thyroid hormone status, histomorphometric findings and iodine content of the thyroid gland]. / Prüfung von Extraktionsschroten aus Winterrapssaat mit unterschiedlichem Glucosinolatanteil an Schweinen unter Berücksichtigung der Iodversorgung. 2. Mitteilung. Schilddrüsenhormonstatus, histomorphometrischer Befund und Iodgehalt der Schilddrüse.

In the experiment, 2 x 12 growing pigs received 19 or 6.7 mmol glucosinolates + aglucones/kg feed via conventional rapeseed meal (RSM) or RSM of a newly bred variety. These pigs and 24 littermates pair fed with a soya bean meal (SBM) diet were subdivided in groups of 4 animals each. Their diet contained either no supplementary iodine or an iodine supplementation of up to 1 mg/kg feed. In the RSM and SBM groups the lack of additional iodine lowered the serum T4 and T3 content below the detection limit and caused goitre with about 1 mg iodine in the total thyroid. The SBM diet with 0.0625 mg supplementary iodine/kg increased the serum T4 level and reversed the thyroid enlargement but not that of epithelial cells. The hypothyroidism (goitre and serum T4 level approximately 10 nmol/l) still existed in the case of this iodine dosage together with the RSM of the newly bred variety. A serum T4 level comparable to that of the animals fed SBM was only reached by supplementing the low glucosinolate diet with 0.25 mg iodine/kg feed. The iodine content of the thyroid, however, was reduced by 50 per cent. Though thyroid and epithelial cells were enlarged, this enlargement was not so obvious as in animals exposed to higher glucosinolate level. In spite of 1 mg supplementary iodine/kg feed, the feeding of the conventional RSM resulted in a lower serum T4 level a reduced thyroid iodine content and the enlargement of thyroid and that of epithelial cells. Compared to the high glucosinolate RSM, a significantly lower antithyroid effect of the low glucosinolate RSM was found in pigs with iodine supply. The degree of thyroid enlargement and the serum T4 level were the criteria.

Effect of varying glucosinolate and iodine intake via rapeseed meal diets on serum thyroid hormone level and total iodine in the thyroid in growing pigs.

In a trial with 50 fattening pigs (20 kg initial body weight), the effect of untreated rapeseed meal (RSM) (148 mmol glucosinolates and aglucones per kg dry matter) on the thyroid was compared with RSM treated with Cu2+ (9.5 mmol glucosinolates and aglucones per kg dry matter) and soybean meal (SBM). The diets containing 8% RSM were supplemented with 0.0625-1.0 and the SBM diet (control) with 0.125 mg iodine kg-1 (I). In comparison with SBM fed control, RSM treatment with Cu2+ resulted in a complete normalization of feed intake and growth. Only untreated RSM without I supplementation depressed performance and resulted in symptoms of I deficiency, but the thyroid and liver weight were also increased and the serum T4 content was significantly reduced in animals which were given RSM not supplemented with I, but treated with Cu2+. In young pigs (4 weeks) a plateau of the serum T4 content was achieved from 0.5 mg I kg-1 of the RSM diet onwards. In contrast, when the concentration of goitrogens was reduced by the treatment with Cu2+, the serum T4 level was increased significantly in groups fed with 0.125 mg I kg-1 diet and more. In older pigs (15 weeks) neither the content of goitrogens nor the I dosage affected the serum T4 level. On the other hand, the I content in the thyroid was a good indicator of the different goitrogenicity of the diet in the case of a low I supply. The present investigations show that pig diets with RSM (greater than 10 mmol glucosinolates and aglucones kg-1) should contain at least 0.5 mg I kg-1, but 0.1 mg supplementary I per kg is sufficient in diets without or with a low content (less than 1 mmol glucosinolates and aglucones per kg-1) of antithyroid compounds.

[The phosphorus supply of swine between 11 and 38 kg. live weight. 2. The phosphorus, calcium and ash deposit in skeletal and soft tissue homogenates during P deprivation and during the use of two different phosphate feedings and different ration conditions]. / Untersuchungen zur Phosphorversorgung von Schweinen im Lebendmasseabschnitt 11-38 kg. 2. Mitteilung. Der Phosphor-, Kalzium- und Ascheansatz im Skelett- und Weichgewebehomogenat bei P-Unterversorgung und bei Einsatz von zwei verschiedenen Futterphosphaten sowie unterschiedlicher Rationsgestaltung.

The influence of phosphorus (P) supply on the content of ash, P and Ca of the skeleton and soft tissue as well on the P deposition in the empty body of pigs (approximately 35 kg live weight) was studied in 3 individual feeding experiments with different diets (P-content 2.97, 2.41 or 3.7 g/kg diet). In each experiment 2 of the 3 groups (7 or 8 animals per group, initial weight approximately 11 kg) were supplemented with the feed grade phosphates "Rükana" or "Cefkaphos". In the experiments the supplemented amount of P as "Rükana" or "Cefkaphos" was 2.50, 2.33 or 0.5 g/kg of the diet. After intake of approximately 65 kg of the diet the animals were slaughtered. Homogenates of bones and soft tissues of the left half of the empty body were analysed for ash, P and Ca. Both of the feed grade phosphates increased these parameters in the skeleton and soft tissues as well the P deposition in the body to the same level. In the middle of the experiments the P deposition per kg live weight gain amounted to 4.6 g ("Rükana") and 4.4 g ("Cefkaphos").

[Testing in swine of meal extracted from winter rapeseed with different glucosinolate content with regard to iodine supply. 1. Characterization of rapeseed extraction particles and fattening results]. / Prüfung von Extraktionsschroten aus Winterrapssaat mit unterschiedlichem Glucosinolatanteil an Schweinen unter Berücksichtigung der Jodversorgung. 1. Mitteilung. Charakterisierung der Rapsextraktionsschrote und Mastergebnisse.

In a feeding experiment with 48 growing pigs 16% high glucosinolate rapeseed meal (HGRSM) (136 mumol glucosinolates + aglucones/kg dry matter, DM) or low glucosinolate (LG) RSM (48 mumol glucosinolates + aglucones/kg DM) in the feed were compared with 14% soya-bean meal (SBM) in each case. It were established 24 pairs of animals, which received the same quantity of the isonitrogenous but not isocaloric diets with SBM and the both RSM (pair fed). Four of the 2.12 animal pairs were not given supplementary I, four received 0.25 mg supplementary I/kg feed. Further four animals which were fed on LGRSM or HGRSM were provided with 0.0625 or 1 mg supplementary I/kg feed. In case of high glucosinolate intake (HGRSM) the lacking I supplementation decreased feed intake and growth and led to remarkable I deficiency symptoms from the fifth week onwards. The 2/3 lower glucosinolate dosage of the LGRSM diet also decreased performance and provoked I deficiency, however significantly later. The investigated I dosages (greater than 0.0625 mg/kg feed) did not effect the performance. In the experiment the eight animals which received LGRSM with supplementary I consumed 13% more feed than animals fed on HGRSM (P less than 0.05). The additional weight gain was 20% (P less than 0.05). Comparing the live weight gain of the SBM and RSM fed animals (pair fed) there was a significant increase of 9% versus the HGRSM groups and 5% versus the LGRSM groups.

[The phosphorus supply of pigs in the body weight category of 11-38 kg. 1. The effect of the phosphorus supply on the performance, nutrient digestibility, protein and fat content in soft tissue and skeleton and protein and fat deposits]. / Untersuchungen zur Phosphorversorgung von Schweinen im Lebendmasseabschnitt von 11-38 kg. 1. Mitteilung. Der Einfluss der Phosphorversorgung auf die Leistung, die Nährstoffverdaulichkeit, den Protein- und Fettgehalt im Weichgewebe und Skelett sowie den Protein- und Fettansatz.

The influence of phosphorus supply on performance and nutrient composition of the empty body was studied in two individual feeding experiments with two and three groups resp. (7 or 8 animals per group). The phosphorus content of the unsupplemented diet was in the experiments I and II 2.97 and 2.41 g/kg, the supplemented phosphorus (as monocalcium phosphate) amounted of 2.5 and 2.33 g/kg diet respectively. The phosphorus supplementation increased live weight gain in both experiments by 84 and 45% and improved feed conversion by 35 and 23% respectively. Phosphorus deficiency did not influence the digestibility of nutrients. The fat content of soft tissue and skeleton of the phosphorus deficient animals was increased. They deposited 0.7 kg more fat (in both experiments) and 1.5 or 0.7 kg less protein in experiment I and II respectively. The utilisation of energy for deposition was not influenced by the different phosphorus supply.

[The performance of weaned piglets after a five week weaning period in relation to the weaning weight, the feed composition and the use of an effective ergotropic]. / Die Leistung nach fünf Wochen Säugezeit abgesetzter Ferkel in Abhängigkeit von der Absetzmasse, der Futter-zusammensetzung und dem Einsaz eines wirksamen Ergotropikums.

In a three-factorial experiment with 216 piglets of the same age (33 +/- 4 days) but a different weight (weaning weight from 5.5 to 9 kg) a conventional piglet rearing feed containing 20% crude protein (standard), a high-energy diet and a low-protein diet (16% crude protein) were tested. In three weaning weight classes the three diets were fed without or with Bisergon [2-N-(2-hydroxyethyl)-carbamoyl-3-methylquinoxaline-1.4-dioxide] over a period of 21 days. From the 22nd to the 71st day after weaning all the piglets received the standard diet without ergotropic. Among the factors studied the Bisergon supplement had the biggest effect. The additional weight gain varied from 9% in case of heavy piglets fed the high energy diet to 150% in case of light piglets fed the low protein diet. The ergotropic improved feed conversion by 22% and lowered the frequency of gastrointestinal diseases requiring treatment by 28%. At the end of the rearing period the weight of the piglets initially fed with Bisergon (means = 34.6 kg) was significantly higher than that of the control animals (means = 31.6 kg). The weaning weight and the diets influenced the final weight especially in the groups without ergotropic. In this case the piglets fed with the high-energy diet gained 30% more and those fed with the low-protein diet 40% less compared with the standard group. The average live weight gain of the light piglets (weaning weight 6.1 kg) was 30% lower than that of the heavier piglets (weaning weight 8.5 kg). The frequency of treatment against diarrhoea of the heavy piglets was by one third lower than that of the light animals. The piglets fed with the low-protein diet appeared to show a limitation of gastrointestinal diseases, but these animals also had the lowest feed intake. Independent of the Bisergon supplementation the weaning weight clearly influenced the live weight after the 10-week experiment. The initially better development of the animals started with the high-energy diet was compensated. In contrast to this, the piglets weighing 6.1 and 7.2 kg fed with the low-protein diet could not compensate the retarded development in comparison with the piglets fed with the standard or the high-energy diet. This experiment confirms the enormous improvement of the performance and of the health status of weaned piglets caused by the ergotropic Bisergon.(ABSTRACT TRUNCATED AT 400 WORDS)

Growth impairment caused by dietary nitrate intake regulated via hypothyroidism and decreased somatomedin.

The effect of 2 days or 6 weeks administration of the diet containing 3 per cent potassium nitrate on serum level of thyroxine (T4), triiodothyronine (T3), nitrate, methemoglobin and somatomedin activity was investigated in piglets aged 56 days. Sufficient iodine intake by mothers prevented a decrease of T4 level in piglets after 2 days administration of nitrate. However, after 6 weeks of nitrate administration a striking decrease of T4 level was found (average level less than 10 nmol l-1) which could not be prevented even by the addition of 0.5 mg iodide per kg diet. No adaptation to nitrate administration was observed. After long-term administration of nitrate a significant decrease of serum somatomedin activity was found which also showed a positive correlation with a decrease of body weight gain.

[Importance of stable gastrointestinal microflora in growing animals]. / Zur Bedeutung einer stabilen Magen-Darm-Flora bei wachsenden Tieren.

A zysbiosis can be caused by food constituents. Food portions with 40% rye for chickens release a destabilisation of the gut flora. This can be prevented by effective stabilizers. Early weaned piglets harbour high numbers of E. coli in their ileum and jejunum content. These become decreased by about three tens powers by affective gut flora stabilizers. Simultaneously the body mass rises considerably without an increase of the food consumption with reference to the living mass. Partially, the ergotropic effect of the gut flora stabilizers is attributed to the smaller expense for the immune defence. Therefore, a new hypothesis for the growth stimulating effect of ergotropics for early weaned piglets is created.

[Effect of iodine, copper and zinc supplements to rations with a high quota of rapeseed extract meal on the growth and thyroid function of fattening swine. 2. The effect of the iodine supplement on nutrient digestibility and on protein and energy retention]. / Der Einfluss von Jod-, Kupfer- und Zinkzulagen zu Rationen mit hohem Rapsextraktionsschrotanteil auf Wachstum und Schildrüsenfunktion des Mastschweines. 2. Mitteilung. Der Einfluss der Jodzulage auf die Nhrstoffverdaulichkeit sowie den Protein- und Energieansatz.

Three groups of six pigs each (live weight at the beginning of the experiment 20 kg) were given a cereal ration with 8% rape seed meal. Group I did not receive a J supplement and was fed ad libitum. The rations of groups II and III were supplemented with 1 mg J/kg feed. The feed intake of group II was limited to the amount consumed by group I (pair fed); group III received the feed ad libitum. The daily weight gains of the 3 groups were 327, 377 and 613 g, feed expenditure 3.79, 3.68 and 3.47 kg/kg gain. In an N balance experiment carried out with 3 animals each from groups I and II, 41.4% of the N taken in group I and 43.8% in group II were retained (p greater than 0.05). Liver, intestinal fat and leaf were heavier in group I (p less than 0.01), the protein content of the empty body, the bones and bristles significantly lower than in group II. Protein retention in group II was 14% higher than in group I. In case of iodine deficiency protein retention is lower, energy retention, however, is largely unchanged.

[Effect of iodine, copper and zinc supplements to rations with a high quota of rapeseed extract meal on the growth and thyroid function of fattening swine. 3. The effect on weight and the histomorphometric findings in the thyroid and on the serum T3 and T4 concentrations]. / Der Einfluss von Jod-, Kupfer- und Zinkzulagen zu Rationen mit hohem Rapsextraktionsschrotanteil auf Wachstum und Schilddrüsenfunktion des Mastschweines. 3. Mitteilung. Der Einfluss auf Masse und histomorphometrischen Befund der Schilddrüse sowie die T3- und T4-Konzentration des Serums.

Studies were made with a total of 272 fattening pigs. Iodine deficiency both in rations of soya bean meal and rape seed meal increased the weight of the thyroid gland and the height of the epithelium cells and significantly reduced the T4 and T3 level in the serum. Iodine supplements to the rape seed meal rations distinctly diminished the goitrogenic effect, did not, however, cancel it out. Stage of goiter and depression of consumption were--different shown by the T3 and T4 level in the serum. Highly significant relations were calculated between live weight gain, weight and the height of the epithelium cells on the one hand and the T4 level in the serum on the other. Iodine supplementations of rations without thyrostatic components should amount to greater than or equal to 0.1 mg/kg. Iodine supplementations of 0.5 mg/kg feed are at present recommended to rations with rape seed meal quotas of less than 8%.

[Effect of iodine, copper and zinc additions to the diet with a high proportion of coarse rape meal extract on the growth and thyroid function of fattening pigs. 1. The effect on fattening performance]. / Der Einfluss von Jod-, Kupfer- und Zink-Zulagen zu Rationen mit hohem Rapsextraktionsschrotanteil auf Wachstum und Schilddrüsenfunktion des Mastschweines. 1. Mitteilung. Einfluss auf die Mastleistung.

In three experiments with fattening pigs the supplementation of a ration with 8% rapeseed oilmeal (RSO) with 1 mg J/kg resulted in an increased weight gain per day of 31, 94 and 87%. On the other hand, only 83, 76 and 84% of the weight gain of the soybean oilmeal control groups were achieved. The additional supply with 250 mg Cu (experiments II and III) increased the weight gain to 84 and 96% in comparison to the unsupplemented control groups. The combination of J + Cu + Zn lead to the same performance as that of J + Cu (experiment III). In the RSO groups without J-supplement changes in body proportions and parakeratosis could be observed after approximately equal to 7 weeks. After the sole supplementation of Cu these symptoms occurred approximately equal to 4 weeks later. In vitro, the supplementation of RSO with a CuSO4 solution resulted in a decrease of vinylthiooxazolidon and isothiocyanate in line with the CuSO4-concentration. 0.2 mg J/kg feed (experiment III) resulted in the same fattening performance as the supplementation of the ration with 1 mg J and outwardly visible deficiency symptoms. The results show that Cu, depending on its quota, results in a decrease of goitrogenics in the feed and that J and Cu supplementation to rations with rapeseed oilmeal have an additive effect and that parakeratosis can be prevented by J-supplementation.

Influence of phytogenic substances with thyreostatic effects in combination with iodine on the thyroid hormones and somatomedin level in pigs.

Growing pigs were given 8% rape seed meal (RSM), which was offered without or with different iodine-supplements and further trace elements. RSM without I-supplementation reduced food intake and weight gains by more than 50%, thyroid weight increased by the factor 6, T4 declined below the detectable limit, T3 by two thirds and somatomedin activity by 50% compared to the control group (soy bean meal). In spite of supplementation with iodine and further trace elements the T3-level reached the level of the control group in no variant due to nutrient deficiency (reduced food intake) and the conversion-impeding effect of goitrogenic substances. The same is true for Sm-activity and weight gains, whereas the T4-level increased even above the level of control animals due to I-supplementation. There are significant correlations (correlation coefficients 0.77 and 0.64 resp.; p less than 0.001) between food intake and T3-concentration resp. and Sm-activity. This study demonstrate that the reduced growth in case of the intake of phytogenic substances with thyreostatic effects is directed by the diminished food consumption and the peripheral hypothyroid situation via decreased Sm-synthesis. The high content of thyreostatic substances in tissues of rape seed fed animals is a potential danger for the human consumer.

[Vitamin A requirements of growing swine. 3. Effect of vitamin A supply on the state of health of piglets and fattening swine]. / Untersuchungen zum Vitamin-A-Bedarf des wachsenden Schweines. 3. Mitteilung. Der Einfluss der Vitamin-A-Versorgung auf den Gesundheitszustand von Ferkeln und Mastschweinen.

Diseases and losses were registered in dependence on vitamin A supply with 2,035 pigs (6.5-114 kg live weight). The histologic examinations comprised various organs of 72 animals. The content of the main protein fractions as well as antibody titre after supplementing antigenes were determined in the serum of 104 animals. The feeding of a vitamin-A- and carotinefree casein-starch-respectively a Vitamin-A-free cereal-soybeanmeal-diet led to deficiency symptoms after 7-8 respectively 16-19 weeks of experiment particularly in the shape of nervous disturbances and voice affectations. Histologically a hyperplasia and a metaplasia of the epithelium of the big ducts in the salivory gland could be proved. The repletion of a part of the avitaminotic animals by means of oral (500 I.U./kg feed) and parenteral (500,000 to 1,000,000 I.U. i.m.) vitamin A administration is proof of a lack of vitamin A. Vitamin A and provitamin dosage did not influence diseases and losses with the exception of the occurrence of deficiency symptoms. The protein content of the serum as well as that of the globulin fractions alpha, beta, gamma did not change, the albumin content was lower in the groups without vitamin A (p greater than 0.05). Antibody titre against the lipopolysaccharide of salmonella dublin and human gamma globulin were diminished in piglets and fattening pigs fed vitamin A free (p less than 0.05). Taking the criterion of animal health, a vitamin A requirement higher than for growth (250 I.U./kg feed) cannot be derived.