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13.
Bull World Health Organ ; 49(3): 245-50, 1973.
Artigo em Inglês | MEDLINE | ID: mdl-4367777

RESUMO

Sporadic cases of paralytic poliomyelitis are being reported with increasing frequency, particularly in unvaccinated persons, in several countries in which the disease had been absent for several years following adequate initial vaccination programmes. In Ontario, two paralytic cases occurred in unvaccinated children after several disease-free years. Detailed studies of the strains of poliovirus type 1 isolated from these patients showed that they were not vaccine strains. Contact surveillance in one case showed that 21 originally unvaccinated contacts were also excreting virulent virus.


Assuntos
Poliomielite/microbiologia , Poliovirus/isolamento & purificação , Adolescente , Criança , Humanos , Masculino , Ontário , Poliomielite/epidemiologia , Poliomielite/prevenção & controle , Vacina Antipólio Oral , Vacinação
19.
Can Med Assoc J ; 106(9): 980-2, 1972 May 06.
Artigo em Inglês | MEDLINE | ID: mdl-4554732

RESUMO

The efficacy of an attenuated rubella virus vaccine, Cendevax, was tested on 65 school children. Forty-nine of them (75%) had pre-existing antibodies and in these there was no increase in the HAI antibody titres after administration of the vaccine. Sixteen children (25%) had no demonstrable rubella HAI antibody prior to vaccination. From the latter group, postvaccination serum samples were available from only 11, and 10 of these seronegative children showed seroconversion after vaccination. The geometric mean HAI titre was 1:180. Seven of the 10 postvaccination serum samples had complement-fixing antibodies and specific IgM antibodies were detected by the immunofluorescence test in 8. No correlation was observed between the CF and the IgM antibodies.


Assuntos
Anticorpos/análise , Vírus da Rubéola , Vacinas Virais , Criança , Testes de Fixação de Complemento , Feminino , Imunofluorescência , Testes de Inibição da Hemaglutinação , Humanos , Imunoglobulina M/análise , Injeções Subcutâneas , Masculino , Faringe/microbiologia , Rubéola (Sarampo Alemão)/imunologia , Vacina contra Rubéola/administração & dosagem , Vírus da Rubéola/isolamento & purificação
20.
Can Med Assoc J ; 106(4): 327-30, 1972 Feb 19.
Artigo em Inglês | MEDLINE | ID: mdl-4551395

RESUMO

The applicability of the immunofluorescence (IF) test to the diagnosis of primary rubella infection was investigated. The test is based on the detection of rubella-specific antibodies in the IgM fraction of immunoglobulins. The results indicate the usefulness of the IF test for the diagnosis of primary rubella infection on a single serum specimen collected at a proper time. The test is also of value in the differentiation of primary infection from reinfection, since in reinfection no rubella-specific antibodies are found in the IgM fraction. The test is also valuable for the detection of fetal infection in utero since the persistence of IgM antibodies in pregnant women is indicative of fetal infection.


Assuntos
Imunoglobulina M/análise , Rubéola (Sarampo Alemão)/diagnóstico , Especificidade de Anticorpos , Diagnóstico Diferencial , Feminino , Doenças Fetais/diagnóstico , Imunofluorescência , Testes de Inibição da Hemaglutinação , Humanos , Gravidez , Complicações Infecciosas na Gravidez/diagnóstico , Recidiva
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