A dual-site trauma system during COVID-19 pandemic - Our experience in a high-risk area with 60-day mortality report.

AIM: We set up a COVID-free trauma site due to the high rates of COVID-19 infections within our hospital. We aimed to determine the incidence of post-operative COVID-19 infection within the first two weeks post-treatment at the COVID-free site and the postoperative mortality rate. We analysed data for non-hip fracture and fragility hip fracture patients separately. METHOD: Data was collected for 138 patients presented during the study period, having 147 operations in total. 103 were non-hip fracture patients and 35 were hip fracture patients. RESULTS: All patients were followed up and none of the non-hip fracture cohort developed symptoms of COVID-19 infection. Postoperative 60-day mortality rate for this cohort was 0.97%. Of the 35 hip fracture patients, none were tested positive for COVID-19. However, two patients were treated as suspected COVID cases due to their symptoms. CONCLUSION: Establishing a separate site with screening for COVID-19 infection can allow safe emergency surgery.

First report of postoperative intracranial Weeksella virosa infection.

A 49-year-old female underwent multiple craniotomies for resection of recurrent malignant meningiomata (WHO grade III). She re-presented with sepsis due to a ventricular empyema. The craniotomy wound was urgently debrided, and isolates of the gram-negative rod, Weeksella virosa, were identified on 16S PCR. This species is most commonly found as a genitourinary commensal. We present the first documented intracranial infection by Weeksella virosa and its successful treatment with oral ß-lactam antibiotics.

The case for outpatient treatment of Plasmodium falciparum malaria in a selected UK immigrant population.

UK guidance recommends that all patients with falciparum malaria be admitted to hospital, although a number of cohort studies in the developed world demonstrate that outpatient treatment of falciparum malaria is feasible and safe in selected patients. We review the literature on outpatient treatment in developed countries and present local data from East London where a selected immigrant population were successfully treated as outpatients. Although it is premature to claim that outpatient treatment of falciparum malaria is safe in all selected patients, we conclude it is time for a large UK-based safety study or randomised trial to dispel the belief that all patients with uncomplicated Plasmodium falciparum must be admitted to hospital.

Hospital-based study of viridans streptococcal bacteraemia in children and adults.

OBJECTIVES: To assess the proportion and clinical significance of bacteraemia caused by viridans streptococci (VS) in immunocompetent adults and children. METHODS: Over a 25-month period, we collected data on all patients with VS bacteraemia at a UK district general hospital. RESULTS: VS caused 50/723 (6.9%) adult and 13/106 (12.3%) paediatric community-acquired bacteraemias. Of the 43 adult and 12 paediatric patient notes reviewed, 26 (47.3%) cultures were of 'definite' or 'probable' clinical significance. No patients were neutropenic and overall penicillin resistance was 11/55 (20.0%). Amongst adults, there were five (11.6%) confirmed or suspected cases of infective endocarditis compared to none in the paediatric cohort. Similar proportions of adults (16.3%) and children (16.7%) had lower respiratory tract infections. Among non-significant cultures, a history of seizures was observed in one (1.3%) adult and four (33.3%) children (p=0.008). Thirty-day mortality was 7.3%. No children and four adults died, one directly attributable to infection. Median adult inpatient stay was 11 days compared to 2 days in the paediatric population (p=0.003). CONCLUSION: Despite cases of infective endocarditis and an incidence of penicillin resistance of 20%, mortality directly attributable to VS infection in immunocompetent adults and children was rare.

Community-acquired Klebsiella pneumoniae meningitis in an alcoholic patient with an infected pancreatic pseudocyst; a case report and review of literature.

We report a case of a 49-year-old male with a history of chronic alcoholism and evidence of a pancreatic pseudocyst on CT scanning. He presented with a 3-days history of fever, loss of appetite and upper abdominal pain. Blood cultures grew Klebsiella pneumoniae and he improved clinically with a seven-day course of intravenous co-amoxiclav and metronidazole. Two weeks later he was readmitted to hospital with impaired consciousness and septic shock, and died three days later in intensive care. Post mortem examination revealed bacterial meningitis and an infected pancreatic pseudocyst. Klebsiella pneumoniae was isolated from the pancreas and meninges.

Passage from India: an outbreak of hepatitis B linked to a patient who acquired infection from health care overseas.

OBJECTIVES: To investigate a nosocomial and community outbreak of hepatitis B to establish how the infections might have occurred. STUDY DESIGN: Descriptive study. METHODS: Four cases of hepatitis B who had stayed in hospital during their incubation periods, a case in one of their household contacts, and three further cases in the community were all linked to a patient who had been infected during a renal transplant in India. Medical records from cases were reviewed to extract information about risk factors for infection. Working practices were reviewed to determine how nosocomial transmissions might have occurred. 'Look-back' exercises were conducted to identify and follow-up other patients and staff who might also be at-risk of infection. Hepatitis B viral sequences from all cases were examined to determine whether they were related. RESULTS: Viral DNA sequences from all nine cases were identical. The primary case had an extremely high viral load due to underlying immunosuppression. Three of the nosocomial transmissions occurred whilst the primary and secondary cases shared general medical wards; two whilst the primary case was in standard isolation. No clear routes of infection were identified. The fourth was associated with a failure of infection control in operating theatres. CONCLUSIONS: Invasive medical procedures in high-prevalence countries carry a clear risk of blood borne viral infections. There is a need for much better awareness of this risk, both among patients who are considering travelling for treatment, and the health professionals who will be caring for them on their return. Infections may be preventable through hepatitis B vaccination. Patients admitted to hospital following invasive medical procedures in high-prevalence countries should be nursed with stringent infection control measures until blood borne viral infections can be excluded. However, patients with hepatitis B who are highly infectious may transmit the virus despite high standards of infection control.