RESUMO
Diethylaminodifluorosulfinium tetrafluoroborate (XtalFluor-E) and morpholinodifluorosulfinium tetrafluoroborate (XtalFluor-M) are crystalline fluorinating agents that are more easily handled and significantly more stable than Deoxo-Fluor, DAST, and their analogues. These reagents can be prepared in a safer and more cost-efficient manner by avoiding the laborious and hazardous distillation of dialkylaminosulfur trifluorides. Unlike DAST, Deoxo-Fluor, and Fluolead, XtalFluor reagents do not generate highly corrosive free-HF and therefore can be used in standard borosilicate vessels. When used in conjunction with promoters such as Et(3)N.3HF, Et(3)N.2HF, or DBU, XtalFluor reagents effectively convert alcohols to alkyl fluorides and carbonyls to gem-difluorides. These reagents are typically more selective than DAST and Deoxo-Fluor and exhibit superior performance by providing significantly less elimination side products.
Assuntos
Boratos/química , Hidrocarbonetos Fluorados/química , Morfolinas/química , Compostos de Enxofre/química , Temperatura , Boratos/síntese química , Halogenação , Hidrocarbonetos Fluorados/síntese química , Estrutura Molecular , Morfolinas/síntese química , Sais/síntese química , Sais/química , Estereoisomerismo , Compostos de Enxofre/síntese químicaRESUMO
In healthcare, consumerism is not a product or program. Instead, it is an orientation to new care delivery models that encourage and enable greater patient responsibility through the intelligent use of information technology. Despite the promise of consumerism, current approaches have not fully realized the potential benefits of improved outcomes and lower cost. We recommend 4 guiding principles to ensure that next-generation innovation yields the returns that providers, patients, and other stakeholders expect: (1) keep the consumer at the center of innovation, (2) keep it simple, (3) link products and services to a broader "ecosystem" of care, and (4) encourage health in addition to treating illness. Now may be a particularly compelling time to invest in a consumerist approach.
Assuntos
Atenção à Saúde/métodos , Difusão de Inovações , Aplicações da Informática Médica , Assistência Centrada no Paciente/métodos , American Recovery and Reinvestment Act , Atenção à Saúde/economia , Reforma dos Serviços de Saúde/economia , Humanos , Educação de Pacientes como Assunto , Assistência Centrada no Paciente/economia , Serviços Preventivos de Saúde , Estados UnidosRESUMO
Aminodifluorosulfinium tetrafluoroborate salts were found to act as efficient deoxofluorinating reagents when promoted by an exogenous fluoride source and, in most cases, exhibited greater selectivity by providing less elimination byproduct as compared to DAST and Deoxo-Fluor. Aminodifluorosulfinium tetrafluoroborates are easy handled crystalline salts that show enhanced thermal stability over dialkylaminosulfur trifluorides, are storage-stable, and unlike DAST and Deoxo-Fluor do not react violently with water.