RESUMO
'Neuroendocrine neoplasms (NENs) are a heterogeneous family of tumors of challenging diagnosis and clinical management. Their incidence and prevalence continue to rise mainly due to an improvement on diagnostic techniques and awareness. Earlier detection, along with steadfast improvements in therapy, has led to better prognosis over time for advanced gastrointestinal and pancreatic neuroendocrine tumors. The aim of this guideline is to update evidence-based recommendations for the diagnosis and treatment of gastroenteropancreatic and lung NENs. Diagnostic procedures, histological classification, and therapeutic options, including surgery, liver-directed therapy, peptide receptor radionuclide therapy, and systemic hormonal, cytotoxic or targeted therapy, are reviewed and discussed, and treatment algorithms to guide therapeutic decisions are provided (AU)
Assuntos
Humanos , Neoplasias Brônquicas/diagnóstico por imagem , Neoplasias Brônquicas/terapia , Neoplasias Gástricas/diagnóstico , Neoplasias Gástricas/terapia , Neoplasias Intestinais/diagnóstico , Neoplasias Intestinais/terapia , Tumores Neuroendócrinos/diagnóstico , Tumores Neuroendócrinos/terapia , Sociedades Médicas , Algoritmos , EspanhaRESUMO
Hasta el 5% de los tumores colorrectales diagnosticados tiene una causa hereditaria. Este tipo de tumores suele presentarse en pacientes más jóvenes y se pueden asociar a otros tumores extracolónicos. El conocimiento de los principales síndromes hereditarios permitirá un adecuado manejo de estos pacientes, incluyendo aspectos como el consejo genético, el diagnóstico precoz y la cirugía preventiva (AU)
Up to 5% of all diagnosed colorectal cancers has a hereditary cuase. Colon cancer arise in younger individuals, and extracolonic tumors are also frequent. A precise understanding of main syndromes will allow the proper managment of these patients, including genetic counselling, screening and prophylactic surgery (AU)