High current short pulse driver using a high power diode laser for optoacoustic biomedical imaging techniques.

Optoacoustic biomedical imaging combines the high spatial resolution of the ultrasound imaging with the specificity of the optical absorption spectroscopy techniques. It is being used in various scenarios such as anatomical, functional and molecular imaging. Typically light sources for this imaging technique is based on solid state lasers since they can produce high energy short optical pulses. However, they are bulky, expensive and the imaging speed is limited because their low pulse repetition rate. High power diode lasers (HPDLs) are a promising alternative for imaging small volume absorbers as they are compact, affordable and allow high repetition rates. However, HPDLs provide relative low peak optical power compared to solid state lasers. Therefore, imaging systems based on diode lasers require much longer pulse duration resulting in lower in-depth resolution and optoacoustic conversion efficiency. HPDLs need dedicated fast electronics to generate short optical pulses. In this work, we have designed, built and test a pulsed diode laser driver based on RF power MOSFETs, specifically considering the optimization of the current pulse in order to maximize the optical peak power, achieving current pulses of more than 900 A with a duration of 50 ns. We have studied the operation of a low cost HPDL out of the manufacturers datasheet ratings without noticeable degradation at high current (> 250 A) and short pulse duration (< 60 ns). We have obtained an optical peak power of 750 W and a energy per pulse of 31.2 µJ at 40 ns optical pulse duration. The optoacoustic images obtained in this operation regime shown a clear enhancement respect to the ones obtained in standard operation of the HPDL.

Interferometric fiber optic sensors for biomedical applications of optoacoustic imaging.

We present a non-metallic interferometric silica optical fiber ultrasonic wideband sensor for optoacoustic imaging applications. The ultrasonic sensitivity of this sensor has been characterized over the frequency range from 1 to 10 MHz. A comparative analysis has been carried out between this sensor and an array of piezoelectric transducers using optoacoustic signals generated from an optical absorbent embedded in a tissue mimicking phantom. Also, a two dimensional reconstructed image of the phantom using the fiber interferometric sensor is presented and compared to the image obtained using the Laser Optoacoustic Imaging System, LOIS-64B. The feasibility of our fiber optic based sensor for wideband ultrasonic detection is demonstrated.

Laser optoacoustic spectroscopy of gold nanorods within a highly scattering medium.

We describe a spectroscopic comparative analysis based on the optoacoustic technique over the wavelength range from 410nm to 1000nm using a Q-switched Nd:YAG pumped optical parametric oscillator tunable source on a gold nanostructure solution located within a highly scattering medium. The advantages of this method over standard spectroscopy techniques are the possibility to localize and monitor the spectroscopic response of absorbing materials located within turbid media. The operation is confirmed using a comparative analysis with the spectroscopic results obtained from a reference measurement scheme, based on a highly sensitive collimated optical transmission setup in parallel and under the same experimental conditions as the optoacoustic technique.

Optoacoustic imaging using fiber-optic interferometric sensors.

An interferometric sensor based on nonmetallic silica optical fiber is presented as an ultrasonic wideband transducer for optoacoustic imaging applications. We have characterized the sensitivity of the optical fiber sensor by detecting optoacoustic signals from an optically absorbing object embedded in a tissue-mimicking phantom and have compared the signals recorded with those detected from the same phantom using an array of piezoelectric transducers. The optical fiber sensor was also scanned along the phantom surface in order to reconstruct two-dimensional optoacoustic images of the phantom. These images have been compared with images obtained using the Laser Optoacoustic Imaging System, LOIS-64B, demonstrating the feasibility of our fiber-optic sensor as a wideband ultrasonic transducer.

Experimental analysis of the locking and nonlinear regimes in lateral coupled diode lasers.

The emission characteristics and the dynamics of laterally coupled diode lasers have been theoretically studied by many authors. However, little experimental work has been done on the locking and nonlinear dynamics of coupled lasers. An experimental characterization of the emission and dynamic characteristics is made by means of the spectrally resolved far field and of the relative intensity noise (RIN) spectrum. It was observed that by varying the bias conditions applied to the device it operates in: (1) locking (lasing both out-of-phase and in-phase lateral modes) or in (2) unlocking. Also it was found that, when the device is lateral locked, several nonlinear and chaotic operation regimes may occur and that the amplitude of the RIN spectrum is highly dependent on the locking conditions.

High-sensitivity ultrasound interferometric single-mode polymer optical fiber sensors for biomedical applications.

This work describes the results of ultrasonic wideband sensors based on single-mode polymer optical fibers that may be used for biomedical applications. We have compared the ultrasonic sensitivities of two Mach-Zehnder interferometric intrinsic optical fiber sensors. One is based on a single-mode polymethylmethacrylate optical fiber and the second on single-mode silica optical fiber, both operating at 632.8 nm. At a frequency of 1 MHz these sensitivities are 13.1 and 0.85 mrad/kPa, respectively. The ultrasonic phase sensitivity of the polymer optical fiber is more than 12 times larger than that from the fused silica fiber in the 1-5 MHz range.

Self-mixing technique for vibration measurements in a laser diode with multiple modes created by optical feedback.

We present experimental and theoretical results obtained from the study of the effects of optical feedback in low-cost Fabry-Perot laser diodes due to the presence of an external cavity created by an external reflective or diffusive vibrating target. Experimental results show that a change in the length of the external cavity produces the well-known amplitude modulation of the optical output power and, depending on the amount of optical feedback, a subperiodicity appears in the amplitude modulation of the output power. The experiments show that the subperiodicity appears independently of the length of the external cavity and is due to mode hopping between different longitudinal laser modes. Numerical analysis focused on the effects observed support that the mode hop occurs between modes whose round-trip phase delay along the external cavity is out of phase, thus producing a subperiodicity of the total amplitude modulation.

Calibration of a high spatial resolution laser two-color heterodyne interferometer for density profile measurements in the TJ-II stellarator.

A high spatial resolution two-color (CO(2), lambda=10.6 microm, He-Ne, lambda=633 nm) interferometer for density profile measurements in the TJ-II stellarator is under development and installation, based in the currently operational single channel two-color heterodyne interferometer. To achieve the objectives of 32 channels, with 4-5 mm lateral separation between plasma chords, careful design and calibration of the interferometric waveforms for both the measurement and vibration compensation wavelengths are undertaken. The first step has been to set up in our laboratories an expanded-beam heterodyne/homodyne interferometer to evaluate the quality of both interferometric wavefronts, a reported source of poor vibration compensation and thus low resolution in the density profile measurements. This novel interferometric setup has allowed us to calibrate the spatial resolution in the profile measurements resulting in approximately 2 mm lateral resolution in the reconstruction of the interferometric wavefront.

Image identification system based on an optical broadcast neural network and a pulse coupled neural network preprocessor stage.

We describe the concept of a vision system based on an optoelectronic hardware neural processor. The proposed system is composed of a pulse coupled neural network (PCNN) preprocessor stage that converts an input image into a temporal pulsed pattern. These pulses are inputs to the optical broadcast neural network (OBNN) processor, which classifies the input pattern between a set of reference patterns based on a pattern matching strategy. The PCNN is to provide immunity to the scale, rotation, and translation of objects in the image. The OBNN provides high parallelism and a high speed hardware neural processor.