Weighing in on monkeypox against the criteria of public health emergency.

The monkeypox, a viral zoonotic disease usually found in forest areas of Central and Western Africa, has spread worldwide through new modes of transmission little understood. The WHO on 23 July 2022, declared the virus a Public Health Emergency of International Concern (PHEIC).The declaration has stirred criticism from leading scientists that the criteria for PHEIC as defined by International Health Regulation have not been met and it is non-transparent and contradictory. This paper reviews the criteria of PHEIC and weighs the rationales behind the declaration to increase the clarity of the WHO's decision, justifications, and legitimacy in the ongoing outbreak.

Exploring the myths surrounding the COVID-19 vaccines in Africa: the study to investigate their impacts on acceptance using online survey and social media.

Purpose: The coronavirus disease 2019 (COVID-19) vaccine is the key to getting out of the pandemic. However, acceptance of the vaccine has been affected by false information and rumors, which have kept people from getting the shot since it was rolled out. Materials and Methods: This study aimed to investigate the various misconceptions surfaced about the COVID-19 vaccines in Africa. We performed an online survey using an anonymous questionnaire to reach out to African respondents by social media and all possible online platforms such as Facebook, WhatsApp, Instagram, Twitter, YouTube, and so forth. The web-based questionnaires about the myths surrounding the vaccines were extracted from nonscientific information, unproven statements, social media posts, news reports, and people's concerns about the safety of the COVID-19 vaccines. Participants indicated their level of agreement with each statement. Results: A total of 2,500 people responded to the online survey in Africa. The two common myths that respondents agreed with were that "since vaccines for COVID-19 have been developed, we can make vaccines for the common cold, human immunodeficiency viruses, and other diseases" (n=892, 35.7%) and that "researchers rushed the development of the COVID-19 vaccines; therefore, it is not very effective, safe and cannot be trusted" (n=595, 23.8%). The range of respondents who neither agreed nor disagreed with these myths was 12.4%-33.0%. The majority (1,931, 77.2%) indicated disagreement with the statement "after getting the COVID-19 vaccine, one can stop wearing a mask as well as taking safety precautions." Conclusion: Myths surrounding the COVID-19 vaccines have impact on acceptance. Exploring them helps public health authorities in Africa dispel them and provide accurate information to promote vaccination campaigns, education, and acceptance.

COVID-19 vaccines development in Africa: a review of current situation and existing challenges of vaccine production.

Following the development of the coronavirus disease 2019 (COVID-19) vaccines and the launching of vaccination, the World Health Organization has reported that the African Continent is lagging in the race to vaccinate its population against the deadly virus. The Continent has received a limited number of vaccines, implying that vaccine production needs to be scaled up in Africa. In this review, we summarize the current situation concerning COVID-19 vaccine development in Africa, progress made, challenges faced in vaccine development over the years and potential strategies that will harness vaccine production success.

COVID-19 vaccination in pregnancy: A review of maternal and infant benefits.

Pregnant women with COVID-19 are more likely to be admitted to the intensive care unit and their babies born prematurely. Clinical trials excluded pregnant women from the vaccine and safety data were limited. However, an increasing number of studies have demonstrated the safety and immunogenicity of the COVID-19 vaccines for pregnant women and their babies including evidence of maternal transfer of antibodies. In addition to these benefits, the vaccines are proved to be effective for both the pregnant women and infants. The current evidence supports the safety, immunogenicity of the COVID-19 vaccine and its effectiveness in reducing the theoretical risk of the infection among pregnant women and their infants. This review summarizes the recent data on the beneficial effects of COVID-19 immunization on both the pregnant mother and infant.

Overcoming barriers to COVID-19 vaccination of pregnant women.

COVID-19 in pregnancy is associated with an increased risk of severe maternal illness, ICU admissions, mechanical ventilation and deaths. Vaccination is the best way to protect pregnant women against these known risks of infection in pregnancy. There is an urgent need to prioritize strategic responses to optimize vaccination among expectant mothers. In this paper, we reviewed potential patient and healthcare provider barriers to COVID-19 immunization and propose effective strategies for overcoming them.

High degree of prostate related LUTS in a prospective cross-sectional community study in Ghana (Mamprobi).

BACKGROUND: Changing voiding patterns, volume and frequency, may sometimes be mistaken for anxiety, stress or increase in fluid consumption. In the aging male population, the commencement of lower urinary tract symptoms (LUTS) may be silent and perceived as "normal" and unrelated to Benign prostatic enlargement (BPE). The purpose of the study was to determine the prevalence of apparently "silent LUTS" (perceived asymptomatic LUTS) in men in a Ghanaian Community as well as its underlying risk factors. METHODS: One hundred and eleven (111) men (40-70 years) were recruited from a community in Ghana. The International Prostate Symptoms Score (IPSS) questionnaire (administered in the local language and English) and ultrasonographic imaging of the prostate volume (PV) were utlized to collect data. IPSS score >7 plus PV > 30 cm3 was definitive of lower urinary tract symptoms. Eighty-one (81) participants were classified "LUTS Negative" (LN) and 30, "LUTS Positive" (LP). Risk factors i.e., cholesterol (CHOL), triglyceride (TG), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), very low-density lipoprotein (VLDL), coronary risk (CR), BMI and Blood Pressure were also determined. RESULTS: The prevalence of LUTS using only IPSS definition alone was 42.3%. However, IPSS in combination with Prostate Volume gave a prevalence of 27.0%. LN subjects had enlarged prostate (41.98%) and LP, 100%. Quality of life (QoL) was better in the LUTS Negative than LUTS Positive group (p < 0.001). In the univariant analysis coronary risk, triglyceride and VLDL contributed to LUTS (p = 0.023, 0.22, 0.22, respectively). In a multivariant analysis HDL-C (p = 0.027), BMI (p = 0.047) and triglyceride (p = 0.019) significantly contributed to LUTS. CONCLUSIONS: The prevalence of LUTS (42.3%) is high. Components of Metabolic Syndrome- HDL-C, BMI, and coronary risk were associated with LUTS. This emphasizes the need for community education.

Post-vaccination COVID-19 deaths: a review of available evidence and recommendations for the global population.

Coronavirus disease 2019 (COVID-19) vaccines undergo rigorous testing in clinical trials to meet high safety standards before rollout to the general population. While over 200 million vaccines are administered in more than 50 countries, coincidental adverse events including deaths and related fatalities are temporally associated with the vaccination campaign. Scientific evidence supports the safety of the vaccines and there are studies proving vaccination outweighs any risk or concerns except in rare cases. Reports of these post-vaccination deaths and misleading claims have fueled hesitancy among individuals that need to be addressed. In this review, we summarize epidemiological data related to COVID-19 vaccine deaths, including instances where scientific evidence exists to justify misinterpretation of surveillance data. Rare cases where vaccination-related deaths or serious side effects exist were described. Available evidence does not support making assumptions and conclusions that the vaccines are necessarily responsible for these deaths or adverse events. In addition, we share lessons from these experiences and recommendations to guide the mass population.

Non-life-threatening adverse reactions from COVID-19 vaccine; a cross-sectional study with self-reported symptoms among Ghanaian healthcare workers.

Health-care professionals in Ghana were among the prioritized high-risk groups to be administered with the initial supply of Oxford/AstraZeneca vaccine procured by the Government of Ghana. This study sought to assess and identify the determinants of COVID-19 vaccine short-term side effects among health-care workers. A cross-sectional study was conducted on 654 Ghanaian healthcare workers between 16th March and 5th May 2021. The study included health-care workers in registered health settings, who had been vaccinated against COVID-19 and consented to participate in the survey. Descriptive statistics, binary and multivariable logistic regression analyses were executed using SPSS version 22 at p < .05. The findings revealed that, 528 (80.7%) of the participants experienced adverse reactions, which lasted between 0 and 2 days among, 347 (53.1%) of the study participants. The most reported adverse reactions were general body weakness, 434 (32.0%), headache 371 (27.3%), and fever, 257 (19.1%). Health workers aged 35-39 and 40-44 years had lower odds of adverse reactions compared with those aged 25-29 years (aOR: 0.34, 95% C.I. 0.186,0.621, p < .001) and (aOR: 0.42, 95% C.I. 0.201,0.890, p = .023). Taking analgesics before vaccination decreased the likelihood of adverse reactions (aOR: 0.28, 95% C.I. 0.185,0.427, p < .001). High prevalence of adverse reactions was found among the healthcare workers, however short-lived. The most reported systemic adverse reactions were general body weakness, headache, and fever. We recommend intensification of campaigns on COVID-19 vaccines and their associated adverse effects to avoid the negative implication on uptake among the healthcare workers and the general population.

A nationwide survey of the potential acceptance and determinants of COVID-19 vaccines in Ghana.

PURPOSE: Safe and effective vaccine together with better treatment remains one of the strategic exist of the coronavirus disease 2019 (COVID-19) pandemic. As in many other countries worldwide, the government of Ghana has expressed its commitment to procuring globally approved and accepted vaccines. This preliminary study aims to analyses these factors that could impact the choice of the vaccine in Ghana. MATERIALS AND METHODS: This cross-sectional survey was conducted among 1,000 Ghanaian respondents from the 14th October to the 12th of December 2020. A structured questionnaire after a series of literature review and was transcribed unto google forms. Dataset was extracted using Excel ver. 2016 (Microsoft Corp., Redmond, WA, USA) and imported into IBM SPSS ver. 22.0 (IBM Corp., Armonk, NY, USA) for analysis. Descriptive statistics, cross-tabulations and logistic regression analyses were conducted at p-value <0.05. RESULTS: The results showed that 541 (54.1%) of the respondents would opt for the vaccines, 907 (90.7%) trusted the healthcare system and 388 (38.8%) had a high-risk perception of acquiring COVID-19. Our inferential analysis found that being married (adjusted odds ratio [aOR], 2.29; 95% confidence interval [CI], 1.10-4.78), salary worker (private: aOR, 2.24; 95% CI, 0.85-5.89; government: aOR, 42.58; 95% CI, 14.09-128.61), and high-risk perception (aOR, 5.35; 95% CI, 3.24-8.82) had a higher OR of accepting COVID-19 vaccine. CONCLUSION: As the government of Ghana prepares to secure COVID-19 vaccines, it is important to understand the state of mind and determinants of COVID-19 vaccine acceptance in the general population. Policymakers and stakeholders should focus on evidence-based community messaging to improve uptake and break the transmission dynamics.

Should Breakthrough SARS-CoV-2 Infection Affect Our Confidence in the COVID-19 Vaccines?

Coronavirus disease 2019 (COVID-19) vaccines have shown excellent clinical efficacy and effectiveness in real-world data. Although they are regarded as a means of ending the global pandemic, some individuals become infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) after immunization. This growing evidence or lack of effectiveness has led to vaccine refusal. This paper sought to help the public gain a deeper understanding of breakthrough events creating the positive perception that vaccines remain effective in ending the pandemic. Discussions vital for the general public's active participation in vaccination are expressed to create confidence or provide a potential solution to the challenge of vaccine hesitancy.

Increasing COVID-19 vaccine acceptance among the general population while maintaining autonomy.

The accelerated dissemination of coronavirus disease, its effects on the general public and healthcare system have been unparalleled. COVID-19 vaccination is critical for reducing the alarming incidence of the infection, promoting herd immunity, preventing associated mortality and morbidity, and maintaining public health and safety. Through the development of COVID-19 vaccines, many people are keen to protect themselves against the virus; however, the willingness for vaccination especially in Africa, is far below what is required to stop the ongoing COVID-19 pandemic. As a result, there is an immediate need to implement plans aimed at increasing population vaccine willingness. The slippery slope is whether sanctions, bans and restriction should be imposed on hesitant persons, since transmission of the epidemic can be prevented through stringent enforcement of the control barriers, while eradicating the disease would necessitate vaccination. This commentary provides recommendations about how to increase population vaccine acceptance while maintaining autonomy.

Knowledge, risk perception and preparedness towards coronavirus disease-2019 (COVID-19) outbreak among Ghanaians: a quick online cross-sectional survey.

INTRODUCTION: Coronavirus disease 2019 (COVID-19) is recognized as global pandemic, affecting more than 300,000 worldwide. Ghana joined the international community by confirming first two COVID-19 cases on March 12, 2020. The study aimed to assess the public knowledge, risk perception and preparedness to respond the COVID-19 in the early stage of the outbreak in Ghana. METHODS: A cross-sectional study was conducted to collect information from Ghanaian during the early stage of the outbreak from 12th to 20th March 2020. Electronic based questionnaire was developed to collected information on the public knowledge, risk perceptions and preparedness to respond the COVID-19. All people who were aged 18 years and over were invited to participate in the study. RESULTS: A total of 350 participants were recruited into the analysis; 56% were males, with the majority of the study population aged between 18-30 years (61.4%), single (68.9%) and attained tertiary education (95.1%). Regarding COVID-19, 62.7% had "good" knowledge about the outbreak, 68.3% had a high risk of contracting the COVID-19 infection and 81.4% had a moderate preparedness skill to prevent and control the disease. Internet (77.1%) was the major sources of information. Knowledge of COVID-19 was significantly associated with education (p<0.001), age (p=0.018), employment (p=0.011) and health-related occupation (P=0.001) but only religion was associated with risk perception. CONCLUSION: Though overall public knowledge was good, disparity exist among the least educated population, there was high risk perceptions and moderate preparedness skill to respond to COVID-19 among our study population. We recommend that educational campaigns through timely online update on COVID-19, van mobilization and mass media broadcasting should target all groups including those in the rural communities.