Assuntos
Adaptação Fisiológica , Regulação da Temperatura Corporal/efeitos dos fármacos , Regulação da Temperatura Corporal/fisiologia , Temperatura Baixa , Isoproterenol/farmacologia , Animais , Câmaras de Exposição Atmosférica , Temperatura Corporal/efeitos dos fármacos , Temperatura Corporal/fisiologia , Desenho de Equipamento , Retroalimentação/efeitos dos fármacos , Retroalimentação/fisiologia , Homeostase/efeitos dos fármacos , Homeostase/fisiologia , Ratos , RetoRESUMO
It has been shown that in experiments where a negative feed-back method has been used, triiodothyronine and beta-adrenomimetic isopropylnoradrenaline exert a significant influence on the work of the whole system of thermoregulation in white rats. This is observed in an upward displacement of the "set-point" temperature.
Assuntos
Regulação da Temperatura Corporal/efeitos dos fármacos , Isoproterenol/farmacologia , Tri-Iodotironina/farmacologia , Animais , RatosRESUMO
The cross circulation method has been used to study contribution of humoral and nonhumoral components to the origin of hypermetabolism (increased level of basal metabolism) and tachycardia under adaptation to cold and experimental hyperthyroidism. Consumption of oxygen, heart rate and rectal temperature have been studied in periods prior to and during the cross circulation. It is shown that under experimental hyperthyroidism contribution of humoral and nonhumoral factors to the origin of hypermetabolism equals 22 and 78%, while that to genesis of tachycardia--44 and 56%, respectively. Under cold adaptation an increase of the basal metabolism level depends on humoral agents by 77% and on changes of the stationary character only by 23%. The nature of adaptation tachycardia is mainly, of the humoral origin (65%).