[Comparative histomorphological analysis of bone fragments consolidation in compression and non-compression mandible osteosynthesis].

On experimentally produced model of mandible fractures (on 18 rabbits) the efficacy of compression osteosynthesis was compared with fixation by usual plates (non-compression osteosynthesis). As was shown by histological study and morphometrical analysis of tissue structures from the region of experimentally isolated in rabbit mandible bone fragments fixed by microdevices for compression and non-compression osteosynthesis in cases of compression osteosynthesis if compared with non-compression osteosynthesis at the experimental terms of 2, 3 and 4 months more intensive new formation and secondary rebuilding of bone tissue with its compactification in the region of cortical layer happened. Histological study and morphometrical analysis of histological pictures showed that reparative osteosynthesis processes were activated in cases of compression osteogenesis not only in cortical but also in sponge layer that together with contact enforcing of the edge of experimentally isolated bone fragment with maternal bone and bone splinters fixation strengthening stipulated for integral positive effect in the form of bone integrity restoration acceleration. In case of non-compression osteosynthesis the processes of reparative bone formation were observed mainly in cortical layer region, in sponge layers they were expressed poorly.

[Use of local UHF hyperthermia and CO(2) laser in treatment of cancer of the lip, lingual mucosa, and bottom of the oral cavity]. / Primenenie lokal'noi SVCh-gipertermii i CO(2)-lazera v lechenii raka guby, slizistoi obolochki iazyka i dna polosti rta.

A total of 424 patients with cancer of the lips, lingual mucosa, and bottom of the oral cavity were treated using local hyperthermia and CO(2) laser. The best results were attained in patients with the disease stage T1N0M0-T2N0M0: 5-year survival without local relapses and metastases was 43.3-58.5% in this group.

[Sex steroid hormone receptors in the cytosolic fraction of cancer and leukoplakia of the oral mucosa]. / Retseptory polovykh steroidnykh gormonov v tsitozol'noi fraktsii raka i leikoplakii slizistoi obolochki polosti rta.

The paper deals with the studies of sexual steroidal hormone receptors in the tumor cytosolic fraction in 37 patients with squamous cell carcinoma and in 18 patients from leukoplakia foci in the oral mucosa. One or two types of androgen and estrogen receptors were detected in the tumor cytosolic fraction in most female (75%) and male (62%) patients with squamous cell carcinoma. The detection rate and the mean values of androgen and estrogen receptors in squamous cell carcinoma of the oral mucosa were associated with sex, age, disease stage, type of growth and site of a tumor. Detection and levels of androgen and estrogen receptors in the leukoplakia foci of the oral mucosa depended on the age of patients. Cytoplasmic estrogen receptors (50%) and oral mucosal squamous cell cancer (34.4%) were much more encountered in the foci of leukoplakia and their mean levels tended to increase. The mechanism of action of sexual steroids on normal and tumor target cells, the role of androgens and estrogens in the pathogenesis of oral mucosal carcinoma and leukoplakia, and possible methods of endocrine therapy for these diseases are discussed.