Prophylactic treatment with the c-Abl inhibitor, neurotinib, diminishes neuronal damage and the convulsive state in pilocarpine-induced mice.

The molecular mechanisms underlying seizure generation remain elusive, yet they are crucial for developing effective treatments for epilepsy. The current study shows that inhibiting c-Abl tyrosine kinase prevents apoptosis, reduces dendritic spine loss, and maintains N-methyl-d-aspartate (NMDA) receptor subunit 2B (NR2B) phosphorylated in in vitro models of excitotoxicity. Pilocarpine-induced status epilepticus (SE) in mice promotes c-Abl phosphorylation, and disrupting c-Abl activity leads to fewer seizures, increases latency toward SE, and improved animal survival. Currently, clinically used c-Abl inhibitors are non-selective and have poor brain penetration. The allosteric c-Abl inhibitor, neurotinib, used here has favorable potency, selectivity, pharmacokinetics, and vastly improved brain penetration. Neurotinib-administered mice have fewer seizures and improved survival following pilocarpine-SE induction. Our findings reveal c-Abl kinase activation as a key factor in ictogenesis and highlight the impact of its inhibition in preventing the insurgence of epileptic-like seizures in rodents and humans.

Puntaje total, calificación médica nacional y cupos según programa de especialidad en el Concurso de Ingreso al Sistema Nacional de Servicios de Salud. Período 2017-2019 / National health services system entrance contest for specialties in Chile. Quotas and scores obtained by applicants

Among the several programs that allow access to medical specialization in Chile, the National Health Services System Entrance Contest (CONISS) is held annually for newly graduated physicians, which has a high number of applicants. The academic qualifications expressed as National Medical Qualification (CMN) are the main item of the scoring system. We reviewed the total scores and the CMN of the different medical specialization programs that exist in the country, which constitutes novel and relevant information for future medical graduates interested in applying to the program. In addition, the quotas of the different programs are reported, expressed as total, free, and used quotas.

Dinámicas Interculturales en contextos (Trans) andinos

Contiene: Introducción. Explorando caminos interculturales desde contextos (trans)andinos: toda belleza es relación, Koen de Munter; El desafío de la interculturalidad, Juan Ansion; Interculturalidad, policulturalidad y creolización-una reflexión y un caso, Anke Van R. Romero F.; Interculturalidad y liberación. A propósito del Carnaval de Oruro, Javier R. Romero F.; Matices cruzadas en nuestras dicotomías actuales: civilización y barbarie, Facundo y las morenadas, Jorge Vargas; El derecho humano y la migración y las ciudadanías interculturales emergentes: el caso de la minoría de origen boliviano en la Ciudad de Buenos Aires, Alcira B. Bonilla y Eduardo J. Vior (U. de Buenos Aires); Interculturalidad, a propósito del proceso político boliviano, Marcelo Lara Barrientos; Dilemas de los caminos de interculturalidad en Bolivia, Máximo Quisbert; Procesos de construcciones interculturales: un relato personal, Edgar Huarachi Mamani; Prácticas interculturales del movimiento cultural de hip-hop en la ciudad de El Alto, María Ángela Riveros Pinto; Los talleres de aprendizaje y promoción intercultural y el Centro Educativo "Santos Marka Túla", Paulo Ramiro Paricagua Titichoca; Encuentro y construcción intercultural, Fernando Rada Arteaga (Oyhana Pukara); Kimsa qamawin wakápacha: tiempo de seres sagrados con tres culturas, Teófilo laime Ajacopa