[The role of lipid metabolic disorders in the development of eczema and psoriasis in chronic alcoholism (clinical and experimental research)]. / Rol' narushenii lipidnogo obmena v razvitii ékzemy i psoriaza pri khronicheskom alkogolizme (kliniko-éksperimental'noe issledovanie).

Blood plasma and red-cell neutral lipid spectrum and red-cell phospholipid spectrum were examined in patients with eczema and psoriasis who abused and did not abuse alcohol. Time course of these parameters was studied in guinea pigs in various periods of chronic alcoholization. Chronic alcoholization was found to be associated with manifest lipid metabolism disorders, the most characteristic shifts being evaluated membrane concentration of free cholesterol and increased level of lisophosphatidylcholin, a membranotoxic agent, as well as reduction of polyunsaturated fatty acid level in phospholipids; these factors may aggravate the course of allergic dermatoses and psoriasis.

[The copper content of the blood and skin in children with circumscribed scleroderma]. / Soderzhanie medi v krovi i kozhe detei, bol'nykh ogranichennoi sklerodermiei.

The authors have demonstrated the pathogenetic significance of elevated copper levels in the blood and involved skin in development of collagen metabolism disorders in children suffering from focal scleroderma. A correlation between elevation of blood serum copper level and the skin process dissemination and activity was revealed. Copper concentration in involved skin of these children surpassed 7-fold the normal value.

[The intensification of lipid peroxidation in the skin for the suppression of experimental dermatitis]. / Usilenie perekisnogo okisleniia lipidov v kozhe dlia podavleniia éksperimental'nogo dermatita.

Guinea pig experiments making use of spectrofluorometry have revealed reduced level of Schiff's bases in skin biopsy specimens obtained from foci of allergic contact dermatitis induced by 2,4-dinitrochlorobenzene (DNCB). Iron sulfate electrophoresis resulted in a decrease of the sensitization and of the allergic contact dermatitis intensity, as well as in enhancement of lipid peroxidation in the skin. These data permit a supposition that reduction of lipid peroxidation is one of the pathogenetic mechanisms of delayed type hypersensitivity, and that lipid peroxidation enhancement in the skin by iron sulfate electrophoresis is one of the possible mechanisms of suppressing allergic contact dermatitis.

[The dynamics of the griseofulvin levels in the blood and skin of guinea pigs during its combined use with alpha-tocopherol]. / Dinamika soderzhaniia grizeoful'vina v krovi i kozhe morskikh svinok pri ego kompleksnom primenenii s al'fa-tokoferolom.

Experiments with 120 guinea pigs have revealed that skin griseofulvin levels depend on blood griseofulvin level and reduce after a prolonged (for 3-4 weeks) administration of the antibiotic in a dose of 30 mg/kg. Reduction of P-450 system enzymes activities achieved with alpha-tocopherol slows down griseofulvin biotransformation rate and significantly elevates its blood serum and skin concentrations.

[The diagnostic importance of research on the lysyl oxidase activity in children with circumscribed scleroderma]. / Diagnosticheskoe znachenie issledovanii aktivnosti liziloksidazy u detei, bol'nykh ogranichennoi sklerodermiei.

Blood serum lysyl oxidase activity considerably varies, these variations correlating with the skin process dissemination, in children suffering from focal scleroderma. This enzyme was undetectable in normal subjects and patients with dermatoses whose clinical symptoms are similar to those of focal scleroderma. Blood serum lysyl oxidase activity elevation is a specific sign, characteristic of patients with focal scleroderma; it therefore may be used for the laboratory diagnosis of this dermatosis, assessment of its dissemination and severity.

[The immediate results of treating patients with infectious forms of syphilis by the abbreviated single-course reserve method]. / Blizhaishie rezul'taty lecheniia bol'nykh zaraznymi formami sifilisa ukorochennym odnokursovym rezervnym metodom.

The results of rapid single-course oletetrine and tetracycline therapy of early syphilis are analyzed. The time of Treponema pallidum disappearance from syphilid discharge, of syphilid regression, and of the first negative results of the routine serologic tests, immunofluorescence 200/ABC and T. pallidum immobilization tests, as well as the blood serum tetracycline level indicate a high therapeutic efficacy of this method and recommend it for wide use.

[Antioxidants in the treatment of patients with discoid lupus erythematosus]. / Antioksidanty v lechenii bol'nykh diskoidnoi krasnoi volchankoi.

The authors present the data of biochemical studies of lipid peroxidation in 63 patients with discoid lupus erythematosus, validating the use of antioxidants combined with prednisolone and delagil in the treatment of such patients.