Assuntos
Pressão Sanguínea , Hipertensão/fisiopatologia , Anti-Hipertensivos/uso terapêutico , Pressão Sanguínea/efeitos dos fármacos , Peso Corporal , Criança , Desenvolvimento Infantil , Pré-Escolar , Hemodinâmica , Humanos , Hipertensão/diagnóstico , Hipertensão/etiologia , Sódio na Dieta/farmacologiaRESUMO
Erythrocytes from children with uremia who are undergoing hemodialysis show normal maximal velocity of NA+-Li+ countertransport and Na+/K+/Cl- cotransport and normal intracellular sodium content. These aspects of intracellular sodium metabolism are not affected by dialysis. The normality of intraerythrocytic cation metabolism in children with uremia is associated with anemia, increased systolic and diastolic blood pressure, reduced body mass index, retention of solutes (urea, creatinine, potassium), a low triiodothyronine and thyroxine syndrome, and high parathormone levels.
Assuntos
Antiporters , Proteínas de Transporte/sangue , Eritrócitos/metabolismo , Diálise Renal , Sódio/sangue , Uremia/sangue , Adolescente , Peso Corporal , Criança , Cloretos/sangue , Feminino , Humanos , Cinética , Lítio/sangue , Masculino , Proteínas de Membrana/sangue , Potássio/sangue , Simportadores de Cloreto de Sódio-PotássioRESUMO
The present report focuses on some aspects of the intra-erythrocytic cation metabolism (e.g. the maximal velocity of the Na+-Li+ countertransport and Na+/K+/Cl- cotransport) in uraemic patients on different dialysis treatments. Patients undergoing dialysis treatment [continuous ambulatory peritoneal dialysis (CAPD) or haemodialysis (HD)] overall showed higher Na+-Li+ countertransport than controls. With regard to Na+/K+/Cl- cotransport, CAPD patients and controls did not differ and both showed, on average, higher values than HD patients. A subgroup of HD patients was studied before and after dialysis. No significant overall changes were detected as a result of the dialysis process with regard to Na+/K+/Cl- cotransport. Na+-Li+ countertransport was significantly reduced by dialysis and a distinctly different response to dialysis was evident according to predialysis values. Patients with high values of Na+-Li+ countertransport showed a significant reduction in this parameter while patients with normal values showed no effect. No distinct association was detected between alteration in either Na+-Li+ countertransport or Na+/K+/Cl- cotransport and the clinical characteristics of the patients. It is concluded that uraemia and/or dialysis influences the maximal velocity of the parameters under investigation. The effect on Na+-Li+ countertransport seems to be similar for both CAPD and HD, while Na+/K+/Cl- cotransport is not altered in CAPD patients.
