[The effect of a medicinal plant preparation on the frequency of episodes of exacerbation of recurrent cystitis and metabolic parameters in patients with type 2 diabetes mellitus taking glyphlosins].

BACKGROUND: The problem of recurrent urinary tract infections (UTI) in patients with type 2 diabetes mellitus (DM 2) is relevant, especially when there is a combination of predisposing factors, such as female gender, history of UTI episodes, and therapy with sodium glucose cotransporter type 2 (SGLT-2) inhibitors, and the choice of effective and safe means could cause some difficulties, including ina terms of the burden of antibiotic resistance. AIM: To evaluate the effectiveness and safety of the phytoproduct Canephron® N for the prevention of exacerbations of recurrent cystitis and the effect on metabolic parameters in patients with type 2 diabetes taking SGLT-2 inhibitors. MATERIALS AND METHODS: Prospective, randomized, open, parallel group study in 60 women. The main group took the drug Canephron® N for 3 months. The main parameters for evaluating were the frequency of recurrence of cystitis, level of albuminuria and LDL-cholesterol peroxidation product - malondialdehyde. RESULTS: Within 3 months of taking Canephron® N, exacerbations of chronic cystitis were diagnosed 2 times less often, a decrease in albuminuria was found in the form of an increase in the proportion of patients with an optimal level of albuminuria by 20%, a 50% reduction in the frequency of the initial increase in albuminuria, and the absence of moderate albuminuria in all patients at the end of course of therapy. A decrease in the level of MDA by 1.4 times was noted (p=0.019). CONCLUSION: Thus, the herbal drug Canephron® N can be used for accompanying therapy and prophylactic treatment in patients with recurrent cystitis on the background of DM 2, taking SGLT-2 inhibitors. The course of therapy should last at least 3 months.

[Ednit influence on oxidation resistance of LDL lipoproteins in hypertensive subjects]. / Vliianie édnita na ustoichivost' lipoproteinov nizkoi plotnosti k okisleniiu u bol'nykh arterial'noi gipertoniei.

AIM: Evaluation of resistance of low density lipoproteins (LDLP) of the serum to oxidation in patients with essential hypertension (EH) before and after course treatment with ednit. MATERIALS AND METHODS: 10 patients with mild or moderate EH aged 38-58 years were given ednit for 1 or 2 months. 10 healthy males aged 35-48 years served control. RESULTS: EH patients had high baseline levels of lipid peroxidation products in LDLP, while antioxidant resistance of LDPL was diminished by 67% (p < 0.05) compared to controls. Ednit treatment for 1 and 2 months enhanced this resistance in mild and moderate EH (p < 0.05). CONCLUSION: Ednit raises resistance of LDLP to oxidation and as ACE inhibitor lowers arterial pressure. Therefore it can be used in EH.

[Characteristics of arterial blood pressure in children aged 10-14 years living in Novosìbirsk (data of a simultaneous epidemiological study)]. / Kharakteristika arterial'nogo daleniia u detei 10-14 letzhitelei Novosibirska (po materialam odnomomentnogo épidemiologicheskogo obsledovaniia).

The authors reported the results of a study of BP levels in children aged 10 to 14 in Novosibirsk using a standard WHO method. Regional normal limits of systolic and diastolic BP with relation to age and sex were presented. The mean levels of systolic and diastolic BP were growing with age, particularly at the age of 11-12. Sex differences in the levels of systolic and diastolic BP were undetectable. In the group of children with raised BP the body mass index was increased, and a rise of diastolic BP was attended by atherogenic shifts in the blood lipid spectrum. Comparative assessment of BP levels was given for Novosibirsk, Moscow and American schoolchildren.