1.
J Labelled Comp Radiopharm
; 62(8): 404-410, 2019 06 30.
Artigo
em Inglês
| MEDLINE
| ID: mdl-31162691
RESUMO
The application of toxic solvents and additives is inevitable for most of the described protocols for 18 F-labeling. Herein, a novel "green" procedure for nucleophilic aromatic radiofluorination of highly activated (hetero)aromatic substrates in pure EtOH is described. Using this method a series of 18 F-labeled (hetero)arenes have been synthesized in radiochemical yields (RCYs) of up to 97%.