[A clinical case of successful treatment of an air cyst of the larynx]. / Klinicheskii sluchai uspeshnogo lecheniya vozdushnoi kisty gortani.

Laryngeal air cyst (laryngocele) is a rare disease that is an abnormal cystic expansion of the deep structures of the laryngeal ventricle. They can be accompanied by serious complaints, such as shortness of breath, difficulty breathing during exercise, as well as at rest with large cysts. Computed tomography is the most effective method for determining the type, localization and degree of laryngocele. Although surgical treatment is considered the method of choice in cases of laryngeal air cyst, the approach significantly depends on the size of the lesion.

[Efficacy of bioregulative drugs in the treatment of otitis media with effusion associated with rhinosinusitis and adenoiditis]. / Effektivnost' preparatov bioregulyatsionnoi meditsiny pri lechenii ekssudativnogo srednego otita, sopryazhennogo s rinosinusitom i adenoiditom.

PURPOSE: Improving of otitis media with effusion (OME) with rhinosinusitis (RS) and adenoiditis treatment effectiveness. MATERIALS AND METHODS: The study included 112 patients 12-18 y.o. with otitis media with effusion, who were divided into 2 groups depending on the treatment scheme. The Group I (the main group) patients treatment included Traumeel S and Euphorbium compositum Nasentropfen S in addition to the standard treatment, and the Group II (comparison), children were prescribed standard therapy. Patients of both groups were divided into 3 subgroups depending on the upper respiratory tract inflammation symptoms: A - patients with adenoiditis; B - with rhinosinusitis and C - combination of adenoiditis and rhinosinusitis. The comparison group (groups IIB and IIC) treatment scheme (children with rhinosinusitis) included topical corticosteroids and the main group patients didn't receive corticosteroids. All patients went through complaints and anamnesis collection, routine otorhinolaryngological and instrumental examination before and after treatment. RESULTS: Analysis of treatment results demonstrated high efficacy of multicomponent drugs with low doses of active ingredients in the therapy of patients with OME, regardless of comorbid pathology. Significantly better results were obtained in the patients treated with bioregulatory drugs when comparing the outcomes of OME therapy in combination with adenoiditis (groups IA and IIA). Comparable efficacy results were obtained in the treatment group of patients with OME associated with RS (in groups IB and IIB as well as in groups IC and IIC), where GCS was received in the comparison group. The high efficacy and safety of bioregulatory drugs makes the use of these agents a promising treatment for patients with OME, RS and adenoiditis.

Oxidative Stress Reactions in Women of Reproductive Age with Metabolic Syndrome.

We analyzed the levels of LPO products and antioxidant defense components in women with the metabolic syndrome. Women with the metabolic syndrome had higher values of substrates with unsaturated double bonds and final TBA-reactive substances in comparison with the control group and higher levels of unsaturated double bonds, primary and end products of LPO, and retinol in comparison with the reference group (women with less than 3 signs of metabolic syndrome). No statistically significant differences between the groups were revealed while estimating the coefficient of oxidative stress; however, there was a tendency to an increase in the median value of this parameter in the group with metabolic syndrome. Thus, the results of the study indicate the activity of LPO reactions at different stages in women of reproductive age with the metabolic syndrome, which points to the necessity to evaluate and monitor the content of these metabolites in the patients of this cohort for the purpose of prevention and treatment.

[Triggers and predictors of development and formation of sensorineural hearing loss]. / Triggery i prediktory razvitiya i formirovaniya sensonevral'noi tugoukhosti.

The purpose of the study is to review the results of scientific researches in recent years in an expanded interdisciplinary view of the problem of etiopathogenesis of sensorineural hearing loss, as well as the role of comorbidities and triggers in the formation of persistent changes in the audio-receiving part of the auditory analyzer.

Activity of LPO Processes in Women with Polycystic Ovarian Syndrome and Infertility.

Specific features of LPO processes and antioxidant defense were studied in patients with polycystic ovarian syndrome (PCOS) and infertility. Changes in LPO processes in patients with PCOS were compensatory, which manifested in increased α-tocopherol and retinol concentrations and moderate decrease in superoxide dismutase activity. Intensification of prooxidant processes was found in the group of patients with infertility without PCOS. The observed changes necessitate differentiated approach to the treatment of these patients.

[Opportunities of electrogastroenterography in pediatric gastroenterological practice].

UNLABELLED: The aim of the investigation is to identify opportunities electrogastroenterography (EGEG) in the survey and individualization treatment of children with inflammatory diseases of the gastrointestinal tract. MATERIALS AND METHODS: We examined five children 10-15 years apparatus Gastroskan-HEV standard overlay electrodes. All children were treated with chronic gastritis in hospital. This diagnosis was confirmed by fibrogastrocopy. The study was conducted in the morning after fasting for 10-12 hours hunger for 40 minutes, and starting in 5-6 minutes after application of the electrodes. Investigated the maximal fluctuations in the range 3.5-4.2 and minimal changes. RESULTS: All children identified acceleration motor-evacuation function of the gastrointestinal tract on the background of hypersecretory reaction. CONCLUSION: EGEG method is noninvasive, has no contraindications and is well tolerated, allowing multiple examine patients regardless of their age and the severity of the condition and correct the assigned therapy.

Structure of molten CaSiO3: neutron diffraction isotope substitution with aerodynamic levitation and molecular dynamics study.

We have performed neutron diffraction isotopic substitution experiments on aerodynamically levitated droplets of CaSiO(3), to directly extract intermediate and local structural information on the Ca environment. The results show a substantial broadening of the first Ca-O peak in the pair distribution function of the melt compared to the glass, which comprises primarily of 6- and 7-fold coordinated Ca-polyhedra. The broadening can be explained by a redistribution of Ca-O bond lengths, especially toward longer distances in the liquid. The first order neutron difference function provides a test of recent molecular dynamics simulations and supports the MD model which contains short chains or channels of edge shared Ca-octahedra in the liquid state. It is suggested that the polymerization of Ca-polyhedra is responsible for the fragile viscosity behavior of the melt and the glass forming ability in CaSiO(3).

[Verotoxin as a major laboratory criterion for Escherichia coli O157-induced enteric infection complicated by hemolytic uremic syndrome in infants in the Omsk region].

The paper presents the results of etiological interpretation of the outbreak of Escherichia coli O157-induced enteric infection complicated by hemolytic uremic syndrome in Omsk in spring 2009. Seventeen infants aged 5 months to 2.5 years were examined; of them 9 patients were on hemodialysis. The diagnosis was verified in 7 children, by isolating verotoxin after fecal enrichment on the concentrating nutrient RIDA Enrichment Bouillon medium containing bile salts and mitomycin C, E. coli O157:H7 cultures on the sorbitol medium and/or by identifying E. coli O157 DNA. Six (4 having verotoxin) infants were found to have rotavirus and noro-virus antigens or DNA/RNA, which may make a contribution into the development of mixed infection and increase the risk of complications.

Fusarium head blight: distribution in wheat in Latvia.

Fusarium head blight (FHB) of wheat has, in recent years, been a very important worldwide disease in intensive growing of cereal. The objectives of this study were to evaluate the occurrence of FHB in wheat in Latvia and to identify the Fusarium species involved. This paper describes the distribution of Fusarium species that were isolated from samples representing winter and spring wheat varieties in Latvia, identified both by the classical morphological analyses of J. Leslie and B. Summerell (2006) and by PCR. The FHB incidence range in winter wheat was 1-20%, in spring wheat was 1-42%. The most significant factor affecting the incidence of fusarial head blight in wheat in Latvia was heightened temperature at the time of an thesis of wheat. In winter wheat 9 Fusarium species caused FHB: F. culmorum, F. avenaceum, F. graminearum, F. equiseti, F. poae, F. oxysporum, F. cerealis, F. sporotrichoides and F. verticillioides were identified by morphological characterization, and 5 were confirmed by PCR-analysis. After experience of 5 years, it can be concluded that the most frequent in winter wheat were F. poae and F. culmorum. In spring wheat from F. culmorum was dominant among 8 Fusarium species. Among 13 varieties of spring wheat, three were sensitive ('Chamsin', 'W 166', 'Azurite') and one was resistant ('Granny') to FHB in conditions of high natural infection in 2009. The monitoring surveys demonstrate a significant presence of FHB in spring wheat in conditions of heightened temperature at the time of flowering in Latvia.

[Effects of middle-ear surgical interventions of different types on peripheral audio reproduction part of the acoustic analyzer in patients with otitis media purulenta chronica].

Different operations on the middle ear were performed in 86 patients with otitis media purulenta chronica (OMPC). Mean bone hearing thresholds in the high-pitched area (10,000-16,000 Hz) were determined and suprathreshold tests were made in 86 patients on day 10 and 6 months after surgery. Minimal changes seen only in early postoperative period occurred in canal wall up operations with tympanoplasty of type I-II. Canal wall down type of surgery had a negative effect on the function of the cochlear receptor system in the early postoperative period. All "open" types of ear surgery, even with tympanoplasty, provoked hearing deterioration with maximum elevation of the hearing thresholds in the high-pitched area (10,000-16,000 Hz). Middle ear surgery without forming a new tympanic cavity results in progressive deterioration of the peripheral part of the hearing receptor system.

[Swimming as a factor of the physical rehabilitation of infants with perinatal central nervous system diseases].

Swimming in the water, which is the immersion surroundings, leads to positive physiological changes in organism. This makes possible to simulate in the water physical exercises of various intensity, providing individual orientation of the first year children's swimming practices.

[The experience of diagnosis, treatment and prophylaxis of gastric and duodenal ulcer in outpatient conditions].

Gastric and duodenal ulcer (peptic ulcer) takes the leading place among the pathology of digestive organs. According to the data of specialists from Consulting-and-Diagnostic Center N 52 among the servicemen with chronic diseases the digestive pathology constitutes 32%. Among these diseases the peptic ulcer occurs in 81% cases. Screening esophagogastroduodenoscopy conducted in 1100 servicemen without any complaints aged 22-50 has revealed duodenal ulcer in 5.4%, gastric ulcer--in 0.7% and gastroduodenitis--in 11.4%. With introduction of modern methods of diagnosis, treatment, rehabilitation and prophylaxis of peptic ulcer 98% patients with disease uncomplicated course began and completed treatment in outpatient conditions.

[A follow-up of patients with anterior optic tract glioma concurrent with type 1 neurofibromatosis].

Fifty-nine patients with anterior optic tract (AOT) lesion concurrent with type neurofibromatosis (NF-1) were followed up for 1 to 36 years (median 5 years). Based on the study, the authors identified several grades of the disease: - stabilization without intervention; - stabilization after treatment; - insignificant negative changes as a slight tumor growth and a further stabilization of the process; - occasionally negative changes irrespective of treatment. The behavior of a tumor is unpredictable. The onset of progression in infancy is a poor predictor. Ophthalmological symptoms are not the criterion that can be used to make a prognosis. The prognosis is largely determined by neurovisualization techniques and primarily magnetic resonance imaging. A uniform slight thickening of AOT structures irrespective of the extent of the process along the AOT should be referred to as a good prognosis. There was no spontaneous tumor regression in any case. By taking into account the beneficial effect of radiotherapy, the authors consider it expedient to use it as monotherapy and in combination with surgery. Bypass surgery on the spinal fluid system frequently fails to entirely solve the problem intracranial hypertension.

[Specific features of manifestation of anterior optic tract gliomas in patients with type 1 neurofibromatosis: ophthalmological and neurovisualizational aspects].

Gliomas of the anterior optic tract (AOT) (optic nerves, chiasms, and visual tracts) are benign slowly growing tumors usually detectable in childhood. These are a rather heterogenic group of tumors. The pattern and course of the disease are frequently affected by the presence of type 1 neurofibromatosis (NF-1) in the patient. The ophthalmological symptoms of AOT lesion in the presence of NF-1 were analyzed in 80 patients aged 1 to 24 years (median 5 years). According to the ophthalmological symptoms and the pattern and extent of lesions to AOT structures, the authors identified 4 groups by the data of neurovisualization techniques (magnetic resonance imaging, computed tomography) and revealed that the ophthalmological pattern reflected the site and degree of lesion to AOT structures. At the same time it is shown that there is a group of silent tumors attending without visual disorders. These tumors have the similar neurovisualization pattern, such as a moderate thickening of AOT structures and they occur in 13.8% of cases, as shown by the authors.

[Maintenance of bactericidal activity of pectin stabilized aqueous solutions]. / Dlitel'nost' sokhraneniia bakteritsidnogo deistviia stabilizirovannykh vodnykh rastvorov pektina.

Maintenance of the bactericidal activity and organoleptic properties of 3% and 5% stabilized aqueous solutions of pectin (Pepidol PEG, 3% and Pepidol PEG, 5%) stored for prolonged periods and at various temperatures was studied. Pepidol PEG was shown to preserve its bactericidal activity and organoleptic properties for 28 months when stored at rather wide ranges of the environmental temperature. The drug did not lose its properties after freezing and subsequent melting. The results of the study allowed to increase the period of Pepidol PEG use up to 18 months and the storage temperature ranges up to -30 degrees to +30 degrees C.

[YAG-Nd laser shunting of the tympanic cavity in patients with exudative otitis media]. / Primenenie IAG-Nd lazera dlia shuntirovaniia barabannoi polosti u bol'nykh ékssudativnym srednim otitom.

A novel method of surgical treatment of exudative otitis media with YAG-Nd laser for shunting of the tympanic cavity has been introduced in therapy of 75 patients. Long-term outcomes of the above treatment characterize it as effective and safe in exudative otitis media.

[Delayed radiation-induced optic neuropathy in patients with tumors in the chiasmal-sellar area after radiation therapy]. / Otsrochennaia radiatsionnaia opticheskaia neiropatiia u bol'nykh s opukholiami kiazmal'no-selliarnoi oblasti posle luchevoi terapii.

Six clinical observations of a rare condition, delayed radiation-induced optic neuropathy (RON) are presented. RON developed in patients with brain tumors treated by radiotherapy and radiosurgery; in the majority of patients the condition developed during exposure to therapeutic doses; its incidence was 0.5% of the total number of patients treated by radiotherapy during this period. Asymmetrical chiasmal syndrome developed rapidly in all the patients. Clinical diagnosis of RON was confirmed by magnetic resonance tomography in all cases, and in one case by morphological analysis. Conservative therapy including hyperbaric oxygenation just stabilized the visual function. Remote period of observation was 42 months.

[Single-photon emission-computed tomography of the brain in craniopharyngiomas in the late postoperative period]. / Odnofotonnaia émissionnaia komp'iuternaia tomografiia golovnogo mozga pri kraniofaringiomakh v otdalennom posleoperatsionnom periode.

The paper analyzes tomographic scanning images of 32 patients with craniopharyngiomas in the late postoperative period. Computed tomographic data allowed the patients to be divided into 3 groups: 1) 10 patients without signs of tumor recurrence or hydrocephalus; 2) 14 patients with recurrent cystic craniopharyngiomas; 3) 8 patients with severe hydrocephalus. Single photon emission computed tomography (SPECT) of the brain indicated regional disturbances of brain tissue blood supply in the frontobasal or frontobasotemporal regions of the right hemisphere (the area of an surgical access and of the removed tumor) and revealed them in the distal areas (frontobasotemporal regions of the left hemisphere, parietal and occipital cortices of the cerebral hemisphere or cerebellar tissue). The compensatory reserves of cerebral circulation were assessed by the foci of relative physiological hyperemia of brain tissue (the cerebellum and the medial portions of the occipital regions of the brain). The findings provide evidence for that the vascular factor is involved in the late postoperative pathological picture in patients with craniopharyngiomas.

[Tumor necrosis factor as indicator of endogenic intoxication severity in acute neurosensory hypoacusis]. / Faktor nekroza opukholi kak pokazatel' vyrazhennosti éndogennoi intoksikatsii pri ostroi neirosensornoi tugoukhosti.

Pathogenesis of acute neurosensory hypoacusis is considered in terms of endogenic intoxication syndrome as impaired microcirculation and development of hypoxia in the periphery of the acoustic analyser are likely consequences of this syndrome. Measurement of tumor necrosis factor alpha level in the supernatant of cultivated mononuclears from patients with acute neurosensory hypoacusis indicated more active production of this mediator compared to donors. This fact justifies further investigations of this disease pathogenesis in respect to disorders in regulation of nonspecific adaptive-compensatory mechanisms.