Oxidative Stress Reactions in Women of Reproductive Age with Metabolic Syndrome.

We analyzed the levels of LPO products and antioxidant defense components in women with the metabolic syndrome. Women with the metabolic syndrome had higher values of substrates with unsaturated double bonds and final TBA-reactive substances in comparison with the control group and higher levels of unsaturated double bonds, primary and end products of LPO, and retinol in comparison with the reference group (women with less than 3 signs of metabolic syndrome). No statistically significant differences between the groups were revealed while estimating the coefficient of oxidative stress; however, there was a tendency to an increase in the median value of this parameter in the group with metabolic syndrome. Thus, the results of the study indicate the activity of LPO reactions at different stages in women of reproductive age with the metabolic syndrome, which points to the necessity to evaluate and monitor the content of these metabolites in the patients of this cohort for the purpose of prevention and treatment.

Activity of LPO Processes in Women with Polycystic Ovarian Syndrome and Infertility.

Specific features of LPO processes and antioxidant defense were studied in patients with polycystic ovarian syndrome (PCOS) and infertility. Changes in LPO processes in patients with PCOS were compensatory, which manifested in increased α-tocopherol and retinol concentrations and moderate decrease in superoxide dismutase activity. Intensification of prooxidant processes was found in the group of patients with infertility without PCOS. The observed changes necessitate differentiated approach to the treatment of these patients.

[Features of the fundal glands of the mammalian stomach and their relation to type of diet (morphometric analysis)]. / Osobennosti fundal'nykh zhelez zheludka mlekopitaiushchikh i ikh zavisimost' ot tipa pitaniia (morfometricheskii analiz).

According to a standartized technique, a morphometrical investigation of the stomach tunica mucosa (STM) has been performed in 11 practically healthy persons and 69 animals representing 4 orders and 9 femilies of Mammalia. In Mammalia, together with a principle similarity in the stomach microscopical structure, there is a great variety of main morphometrical parameters of the STM. The whole complex of these parameters is species-specific. It is determined by the systemic position of the given species and reflects the filogenetically-dependent nutritional specialization. The main mechanism and the filogenetically-dependent characteristic of adaptation to protein nutrition is an increase in the number of the main, but not the parietal glandulocytes. The dependence revealed gives a new interpretation to the problem concerning the relation between the structure and function of the STM in animals with different nutrition type; this dependence makes it possible to consider the problem of ulcerogenesis and its biological prerequisites in the man from new positions.

[Structure of the gastric mucosa following experimental antrectomy]. / Struktura slizistoi obolochki zheludka posle antréktomii v éksperimente

The important role of the antral part of the stomach in sustaining the gastric mucosa tissue homeostasis has been shown in chronic experiment in dogs. In 5-13 months after antrectomy the thickness of the gastric mucosa diminishes by 21% at an average, the height of the fundal glands-by 29%, the amount of the parietal cells-by 54%, the amount of basic cells-by 34%. Hypoplastic lesions of the gastric mucous membrane develop and complete within the first months after antrectomy. After the 5th month the degree of hypoplasia fails to markedly increase, i. e. the shifts found are not of constantly progressing character.