Sequential bilateral cochlear implant: long-term speech perception results in children first implanted at an early age.

PURPOSE: The study aims to assess the benefit of sequential bilateral cochlear implantation in children with congenital bilateral profound hearing loss, submitted to the first implant at an early age. METHODS: We enrolled all the bilateral sequential cochlear implanted children who received the first implant within 48 months and the second within 12 years of age at our Institution. The children were submitted to disyllabic word recognition tests and Speech Reception Threshold (SRT) assessment using the OLSA matrix sentence test with the first implanted device (CI1), with the second implanted device (CI2), and with both devices (CIbil). Furthermore, we measured the datalogging of both devices. Then we calculated the binaural SRT gain (b-SRTgain) and checked the correlations between speech perception results and the b-SRTgain with the child's age at CI1 and CI2, DELTA and the datalogging reports. RESULTS: With the bilateral electric stimulation, we found a significant improvement in disyllabic word recognition scores and in SRT. Moreover, the datalogging showed no significant differences in the time of use of CI1 and CI2. We found significant negative correlations between speech perception abilities with CI2 and age at CI2 and DELTA, and between the SRT with CI1 and the b-SRTgain. CONCLUSIONS: From this study we can conclude that in a sequential CI procedure, even if a short inter-implant delay and lower ages at the second surgery can lead to better speech perception with CI2, children can benefit from bilateral stimulation independently of age at the second surgery and the DELTA.

Cochlear implantation in patients with asymmetric hearing loss: reporting and discussing the benefits in speech perception, speech reception threshold, squelch abilities, and patients' reported outcomes.

OBJECTIVES: This study presents the results obtained in a group of patients with asymmetric hearing loss undergoing cochlear implantation at our institution. Prognostic factors are discussed in relation to different rehabilitative approaches for asymmetric hearing loss remediation. The current literature is also discussed. METHODS: Nineteen adult patients with post-verbal asymmetric hearing loss were enrolled. The results were assessed by means of a speech perception test, completed in silence and with background noise, and a speech reception threshold test (Oldenburg Sentence Test). The subjectively perceived benefits were assessed using the Speech, Spatial and Qualities of Hearing Scale. RESULTS: Statistically significant improvements were achieved by all patients in terms of speech perception and speech reception threshold, and in subjective benefits. CONCLUSION: The results confirm the literature findings which suggest that patients with asymmetric hearing loss generally gain substantial benefit from cochlear implantation because of the binaural input, with significant improvement in speech perception abilities in noise, speech reception threshold, and squelch abilities.

Enlarged vestibular aqueduct and Mondini Malformation: audiological, clinical, radiologic and genetic features.

PURPOSE: When referring to enlarged vestibular aqueduct (EVA) we should differentiate between nonsyndromic enlarged vestibular aqueduct (NSEVA) and Pendred Syndrome (PDS), a disease continuum associated with pathogenic sequence variants of Pendrin's Gene (SLC26A4) in about half of the cases. The study was aimed to analyse the clinical and audiological features of a monocentric cohort of Caucasian patients with NSEVA/PDS, their genetic assessment and morphological inner ear features. METHODS: We retrospectively reviewed the audiologic, genetic and anamnestic data of 66 patients with NSEVA/PDS followed by our audiology service. RESULTS: SLC26A4 mutations was significantly correlated with the presence of PDS rather than NSEVA (p < 0.019), with the expression of inner ear malformations (p < 0.001) and with different severity of hearing loss (p = 0.001). Furthermore, patients with PDS showed significantly worse pure tone audiometry (PTA) than patients with NSEVA (p = 0.001). Anatomically normal ears presented significantly better PTA than ears associated with Mondini Malformation or isolated EVA (p < 0.001), but no statistically significative differences have been observed in PTA between patients with Mondini Malformation and isolated EVA. CONCLUSION: NSEVA/PDS must be investigated in all the congenital hearing loss, but also in progressive, late onset, stepwise forms. Even mixed or fluctuating hearing loss may constitute a sign of a NSEVA/PDS pathology. Our findings can confirm the important role of SLC26A4 mutations in determining the phenotype of isolated EVA/PDS, both for the type/degree of the malformation, the hearing impairment and the association with thyroid dysfunction.

[Computer-assisted image postprocessing in intraoral digital radiography]. / L'elaborazione computerizzata delle immagini nella radiografia digitale endorale.

INTRODUCTION: Computer-assisted postprocessing was performed on selected digital dental radiographs using a professional software for photographic retouching. MATERIALS AND METHODS: The optical characteristics of 22 digital intraoral images (radio-videographies) taken on 18 patients were modified as regards their density and contrast values. Three different kinds of densitometric curves, corresponding to particular changes in post-processing parameters, were preliminary defined as the most effective for the demonstration of root canals and of alveolar bone. They were then applied to each X-ray image and the pictures thus modified were subsequently printed and read on a blind basis by three observers who considered the conspicuity of each structure of interest (root canals and alveolar bone). RESULTS: The results, submitted to statistical analysis, demonstrate that computer-assisted postprocessing can improve the visual yield and the diagnostic effectiveness of digital dental images in 67% of cases for the periapical bone and in 86% of cases for the root canals. CONCLUSIONS: The most effective sets of post-processing parameters established for each structure of interest are proposed together with a pre-programmed function to be introduced into the software of digital radiographic equipments.

[Prostatic volume: suprapubic versus transrectal ultrasonography in the control of benign prostatic hyperplasia]. / Volumetria prostatica: confronto tra studio ecografico sovrapubico e transrettale nel controllo dell'iperplasia prostatica benigna.

INTRODUCTION: During the follow-up of benign prostatic hypertrophy, the urologist needs the repeated evaluation of the gland size to monitor the effectiveness of drug treatment. We investigated the comparative adequacy of transabdominal and transrectal US for prostatic measurements, to possibly replace the gold standard transrectal examination with cheaper, easier and less invasive transabdominal studies. MATERIAL AND METHODS: February, 1994, to May, 1996, we submitted 196 patients to prostate US, with a transabdominal convex probe and a transrectal biplanar probe. The three prostatic diameters were measured and prostatic volume and height calculated. RESULTS: The transverse diameter was the same (+/- 5%) in 31.6% of cases, but transabdominal US overestimated it in 41.8% and underestimated it in 26.5% of cases. The AP diameter was the same in 33.1% of cases, but trans-abdominal US overestimated it in 15.3% and underestimated it in 51.5% of cases. The cranio-caudal diameter was the same in 25.5% of cases, but transabdominal US overestimated it in 59.1% and underestimated it in 15.3% of cases. Consequently, the volume calculated with transabdominal US was the same (+/- 15%) in 27.5% of cases, overestimated in 45.9% and under-estimated in 26.5% of cases; prostatic weight rates were about the same. CONCLUSIONS: Prostatic volume and weight measured with transabdominal US are overestimated in about 50% of cases and are the same (+/- 15%) in about 27% of cases only. Therefore, transabdominal US appears less reliable than transrectal US for prostatic measurements and the latter technique remains the gold standard to monitor drug treatment effectiveness in benign prostatic hypertrophy follow-up.

[Digital panoramic radiography in patients with rigid internal fixations devices after maxillofacial surgery]. / L'ortopantomografia digitale nei pazienti portatori di sistemi di fissazione interna rigida maxillo-facciale.

INTRODUCTION: Digital techniques have found promising applications in dental radiology in the recent past, namely with radiovisiography and digital panoramic radiography. These images present some features making them particularly interesting for alveolar bone studies. MATERIAL AND METHODS: Digital panoramic radiography with light-emitting phosphors was performed on 16 patients during postoperative follow-up. The patients were previously submitted to multiple maxillofacial osteosynthesis with rigid internal fixation devices (32 miniplates, 12 microplates, 14 screws). Digital images were always observed and printed with analogic-like and Xeroradiographic-like post-processing. RESULTS: Digital panoramic radiographs yielded clear and effective images of the maxillary and mandibular arches and of surgical osteosynthesis, as demonstrated by a retrospective evaluation performed by three independent observers on a blind basis (score 3: 60.42%), with no major interobserver differences (p = .7286). Xeroradiographic-like images were the most effective in depicting bone structures and osteosynthesis materials, thanks to their better detailing and typically lower overall contrast. Among the drawbacks of the digital technique, reduced cassette size may prevent the full view of the mandibular arch from the symphysis to both condylar regions. The edge effect, which is typical of Xeroradiographic images, may mask useful details within the trabecular bone close to metal implants. This effect was present in some of our cases, but it was seldom disturbing according to our retrospective evaluation (score 3: 53.40%), with good interobserver agreement (p = .1117). CONCLUSION: Digital panoramic radiography proves to be a useful tool to study metal implants after maxillofacial surgery as well as alveolar bone structure. The digital technique markedly reduces the radiation dose to the patient, which is very important for an X-ray examination that must be repeated several times, often in young subjects.

[Ultrasonography assessment of ossification foci of the wrist and pubertal growth spurt]. / Valutazione ecografica dei nuclei di ossificazione del polso e del picco di crescita puberale.

High-resolution ultrasound (US) of the hand and wrist was compared with radiography in 26 young patients (mean age: 11.4 years) to be submitted to orthodontic therapy. US scans were targeted on the ossification centers critical for the growth spurt, namely the pisiform and adductor sesamoid bones of the metacarpophalangeal joint of the thumb and the cartilage of the distal phalanx of the third finger. All images were retrospectively reviewed on a double-blind basis by two independent observers who gave a conspicuity score to each structure of interest. All the scores were submitted to statistical analysis with the Wilcoxon test. US images clearly demonstrated the initial appearance of the ossification centers of the pisiform and sesamoid bones. These structures appeared as hyperechoic spots causing marked acoustic shadowing. The persistence of the phalangeal cartilage was depicted as a thin rim interrupting the hyperechoic cortical profile of the bone. US results were statistically equivalent to radiographic findings in the pisiform [p (op1) = .3105; p (op2) = .8886] and sesamoid bones of the thumb [p (op1) = .1386; p (op2) = .354]. A statistically significant difference between the two techniques was found in the third finger cartilage (p (op1) = .0277; p (op2) = .0759) because its profile was poorly depicted on some US images. To conclude, wrist US is proposed as a simple and valuable radiation-free support examination for the follow-up of skeletal maturation in adolescents to be submitted to orthodontic therapy.

[Diagnostic imaging in the selection of candidates to orthotopic transplantation of the liver. Experience at a hospital lacking a transplantation department]. / Diagnostica per immagini nella selezione dei candidati al trapianto ortotopico del fegato. Esperienza in un ospedale non dotato di centro per trapianti.

We report the experience of our general hospital in selecting the patients for orthotopic liver transplantation (OLT). Fifty-one patients with cirrhosis were examined and 20 of them submitted to OLT from August, 1992, to November, 1995. For liver studies, the 20 transplant recipients were examined with US and plain and dynamic CT; 15/20 were submitted to CTAP, 10/20 to Lipiodol CT and 17/20 to angiography. The accuracy of these techniques in HCC detection was assessed by correlation with resected whole livers. The accuracy of duplex Doppler and color flow Doppler for portal and/or mesenteric vein thrombosis was evaluated by correlation with resected livers, CT and angiographic findings. Pathologic examinations diagnosed HCC in 5/20 transplant recipients: 2 lesions (1.5 cm and 2 cm; 2 cm and 3.5 cm) were found in 2 resected specimens (total hepatectomy) and 1 lesion was found in 3 cases (2.5 cm, 1.5 cm, 1 cm). The sensitivity of US, plain and dynamic CT in identifying HCC patients was 20%; US and CT specificity rates were 100% and 87%, respectively. CTAP sensitivity was 75% and the sensitivity of Lipiodol CT and angiography was 100%. Therefore, in our series, US was poorly sensitive in the detection of liver cancers, which may depend on the small number of patients, lesion size (< or = 3.5 cm) and the radiologists ignoring clinical and laboratory data on purpose. Nevertheless, the patients with a single HCC not exceeding 5 cm phi or with no more than 3 tumors, none of them exceeding 3 cm phi, are generally considered eligible for transplantation: therefore, our patients chosen for OLT on the basis of US and CT findings were actually eligible for transplantation in spite of US and CT false negative results. At US, the portal vein had an average caliber of 13.5 +/- 2.5 mm in 21/51 patients; the average caliber of the common hepatic artery was 6 +/- 1.5 mm in 49/51 patients; average spleen length was 174 +/- 38 mm. US showed ascites in 28/51 cases. In conclusion, considering also the long stand-by list for OLT, the first selection of transplant candidates could be performed with US and color flow Doppler, plain and dynamic CT. The patients who are ruled out as candidates for OLT on the basis of the findings of these imaging techniques and of clinical and laboratory findings are submitted to no further examination and referred to the transplantation unit. Otherwise, if conventional and color flow Doppler US and conventional CT are not enough to exclude a patient from OLT, the subject is submitted to more invasive (angiography, CTAP, Lipiodol CT) or less widespread (spiral CT, MRI) techniques.

[Digital radiology in dentistry: experience with direct intraoral techniques (radiovideography)]. / La radiologia digitale nell'odontoiatria: esperienza con le tecniche d'acquisizione endo-orale diretta (radiovideografia).

The aim of this paper was to discuss the techniques for intraoral digital radiography (radiovisiography) and to compare their accuracy in dental radiographical diagnosis. Emphasis was given to their potential applications in oral radiology. Radiovisiography was compared with intraoral films and electronic magnifications from digital panoramic radiographs in 38 patients, for a total amount of 36 caries, 27 periapical conditions and 58 metal implants. Moreover, the accuracy of the measurements made with the three techniques was assessed on a specimen of mandibular and maxillary arches containing 28 extracted teeth with endodontic files of known length. Radiovisiography was as effective as intraoral films and more effective than digital panoramic radiographs in the diagnosis of caries and periapical lesions. Nevertheless, it produced a significant magnification and yielded unreliable measurements of root canals and metal implants. Radiovisiography is very easy to use and does not require dark room procedures nor chemicals of any kind. In addition, it reduces patient's X-ray exposure by over 50% with respect to film studies. For these reasons, this technique seems to be worthy of widespread use in dental radiography, with the exception of the conditions requiring an exact measurement of working length.

[The measurement parameters in dental radiography: a comparison between traditional and digital technics]. / Parametri di misura nella radiografia dentale: confronto fra tecniche tradizionali e digitali.

Digital and conventional techniques for dental, panoramic and intraoral radiography, were compared to assess measurement accuracy. The study was carried out on two plastic models of maxillary and mandibular arches, each containing 14 teeth extracted and positioned in their anatomical site. The teeth were prepared by opening the pulpal cavity and inserting endodontic wires within the canals. Intraoral x-ray images were taken with long-cone technique using a commercial high-resolution film and with a charge coupled device (CCD) sensor (radiovisiography). The models were then submitted to panoramic tomography with photostimulable phosphor plates. The length of the canals was measured on each image and compared to the length of the inserted wires. For the digital pictures, the measurement was performed directly on the monitor with the aid of electronic calipers. Magnification averages 3.40%, 9.47% and 14.11% for anterior teeth in intraoral radiography, in radiovisiography and panoramic radiography, respectively. The results demonstrate the presence of some degree of magnification for every radiographic procedure. This effect becomes statistically significant for both radiovisiography and digital panoramic techniques, especially in the latter. In spite of their well-known practical and dosimetric advantages, digital techniques in dental radiology must be used carefully whenever a reliable measurement is required.

[A comparison between endoral radiography and electronic magnification of digital orthopantomography]. / Confronto tra radiografia endo-orale e ingrandimento elettronico da ortopantomografia digitale.

We compared the electronic magnifications obtained from digital panoramic radiographs with intraoral radiographs with a new high resolution film. Fifty-two patients were submitted to both examinations--76 comparative studies and 217 teeth studied in all. The two techniques appeared substantially comparable in terms of diagnostic effectiveness. The measurement of the alveolar ridge was strictly equivalent for the two examinations (< 1 mm disagreement in 80% of cases). The profile of lamina dura and the image of the radicular canal were better depicted with intraoral films. A useful advantage offered by digital images was the possibility of recognizing the soft tissues. In dental caries intraoral films was more effective than digital images and were correctly depicted small carious cavities (< 2 mm depth, 87 vs 74%). Digital panoramic radiography can be considered a promising alternative to panoramic film. Its electronic magnification may be a valuable diagnostic complement to intraoral films for the study of periodontal disease, but it cannot replace intraoral films for the assessment of fine dental details, small caries in particular. The new intraoral film was substantially equivalent to digital images for the assessment of bone lesions and of periodontal disease.

[Photo Compact Disc: proposal for the electronic storage of images]. / "Photo Compact Disc": proposta per l'archiviazione elettronica delle immagini.

We applied the Photo-CD technology to create an electronic image file easy and quick to use to optimize the retrieval of medical images for teaching purposes. We digitized 1,500 slides of diagnostic examinations from the archive of our Institution: the corresponding electronic files were stored on Photo-CD disks. The data relevant to every image were collected and recorded with the help of a relational data-base program. Thus, each user could retrieve the suitable images from the optical disks by a multiple and flexible key-word search. We compared the use of the electronic archive with a traditional hand-based file with the help of 3 teachers committed to prepare a lesson containing 5 slides on different subjects. The use of the electronic image archive corresponded to markedly shorter searching and file updating times. We tried also to assess the capabilites of this filing procedure for image post-processing and for the build-up of self-assessment programs.

Social class and mood disorders: clinical features.

We examined clinical features in 877 in- and outpatients affected by depression who were enrolled in psychopharmacological trials, subdivided according to Hollingshead's method into five social classes. The results showed that social class correlated significantly with the subtypes of mood disorders, with bipolar disorder being more frequent amongst the upper than the lower social classes. Furthermore, as already reported in other countries, social class appeared to influence the psychopathological pattern of depressive symptoms: somatization and anxiety were more frequent amongst the lower social classes, while psychic and cognitive symptoms were more common amongst the upper classes.

Glycosaminoglycan polysulfate (Ateroid) in old-age dementias: effects upon depressive symptomatology in geriatric patients.

1. Glycosaminoglycan polysulfate is a mixture of sulfo-muco-polysaccharides with hypolipidemic activity. A number of clinical studies have indicated that it is effective in improving psychopathology in patients with cardiac and/or cerebral disease associated with arteriosclerosis. 2. A multicenter clinical trial was performed to compare the effects of two different dosages of glycosaminoglycan polysulfate upon depressive symptomatology in patients with multi-infarct dementia and primary degenerative dementia. 3. A total of 39 patients were treated in an 18-week clinical trial which followed a single-blind parallel design. 4. Results indicated that patients with both diagnoses improved significantly in depressive symptomatology over the course of treatment, with particular improvement noted in cognitive disturbance. Drug dosage was not a significant determinant of treatment response for either diagnostic group.

Predictors of compliance with lithium and carbamazepine regimens in the long-term treatment of recurrent mood and related psychotic disorders.

This study examined compliance with lithium and carbamazepine regimens from the perspective of the illness and its characteristics. Patients were more likely to stay in treatment when prophylaxis was begun following a depressive episode and in the presence of congruent psychotic experiences. The reverse was true for grandiose and manic patients and those with somatic preoccupations.

Exploration of the clinical profile of rubidium chloride in depression: a systematic open trial.

Thirty-one female inpatient depressives underwent a systematic open trial with rubidium chloride, 180 to 720 mg/day. By week 2, at least two-thirds had improved significantly (p less than 0.01) as measured by standard rating instruments such as the Brief Psychiatric Rating Scale and the Hamilton Depression Scale. Regression analysis suggested that the retarded endogenous pattern was most predictive of positive response. Treatment-emergent symptomatology, such as diarrhea, polyuria, and excitement, was generally mild and rarely necessitated interruption of the trial. The authors conclude that this salt has shown sufficient clinical promise to warrant more extensive trials under double-blind conditions.

The comparative efficacy and safety of carbamazepine versus lithium: a randomized, double-blind 3-year trial in 83 patients.

The comparative usefulness of carbamazepine and lithium carbonate in the acute and prophylactic management of DSM-III diagnosed major affective, schizoaffective, or schizophreniform psychoses was investigated in a 3-year, prospective double-blind randomized trial with 83 in- and outpatients. The incidence of side effects was similar in both treatment groups, and side effects generally responded well to dosage reduction. Both drugs were effective in two thirds of the patients and appeared about equal in most outcome measures, except for a significantly higher dropout rate for patients with mood-incongruent psychotic features who were assigned to the lithium group. Both drugs appeared more effective in preventing excited rather than depressive symptoms.

Use of carbamazepine in acute psychosis: a controlled study.

A randomized double-blind study was performed to compare the therapeutic effects of lithium and carbamazepine (CBZ) each administered in combination with chlorpromazine (CPZ) for 3 weeks in women with acute psychosis. Thirty patients were studied. The initial dose was 1200 mg/day for CBZ and 900 mg/day for lithium, and it was subsequently modified according to plasma levels and clinical indications. The dose of CPZ was free and depended on the severity of symptomatology. Both treatments produced a significant improvement in psychotic symptoms without significant differences between the treatment groups. Also, as regards tolerability no clinically relevant differences were found between the two groups. During the first week of treatment the CPZ dose required in the CBZ group was significantly lower than that administered to the lithium group, indicating that CBZ had a greater sedative action; however, this difference decreased as treatment continued. These results confirm that CBZ is a valid alternative to lithium in the treatment of acute psychosis.