1.
Pediatrics
; 136(6): e1621-4, 2015 Dec.
Artigo
em Inglês
| MEDLINE
| ID: mdl-26527549
RESUMO
We present a 22-month-old boy with X-linked agammaglobulinemia masked by normal immunoglobulin levels and vaccine seroconversion. Diagnosis was made after strong clinical suspicion of immune deficiency led to identification of markedly reduced B-cell numbers and confirmation with identification of a novel Bruton tyrosine kinase gene mutation. He was commenced on replacement immunoglobulin therapy with excellent clinical improvement. This case highlights the variability of phenotypic presentation and apparent disunity between routine immunologic investigations and severe disease in X-linked agammaglobulinemia, necessitating clinical acumen to make the diagnosis.
Assuntos
Agamaglobulinemia/diagnóstico , Doenças Genéticas Ligadas ao Cromossomo X/diagnóstico , Imunoglobulinas/sangue , Soroconversão , Vacinas/imunologia , Agamaglobulinemia/imunologia , Biomarcadores/sangue , Doenças Genéticas Ligadas ao Cromossomo X/imunologia , Humanos , Lactente , Masculino
2.
N Z Med J
; 124(1339): 102-4, 2011 Jul 29.
Artigo
em Inglês
| MEDLINE
| ID: mdl-21952337