Obstructive uropathy after inguinal herniorrhaphy with a mesh in a renal transplant patient.

A 67-year-old male renal transplant patient presented with a right inguinal bulging mass, and was diagnosed with a right indirect inguinal hernia. The day following inguinal herniorrhaphy, serum creatinine became elevated. The patient was oliguric and had abdominal pain on the first day after inguinal herniorrhaphy with a mesh. We diagnosed him with acute renal failure and subsequently performed acute hemodialysis. The kidney computed tomography showed hydronephroureter, with distal ureter obstruction. With urgent percutaneous nephrostomy, we were able to relieve the obstructive uropathy with distal ureteral stenosis. Subsequently, hernia repair was performed with removal of the mesh, followed by the antegrade ureteral stent insertion. Renal function was recovered after ureteral stent insertion. This case shows that acute renal failure can occur due to ureteral obstruction, complicated by an inguinal hernia repair, and this can be successfully treated with percutaneous nephrostomy and inguinal hernia repair with mesh removal.

Preoperative chemotherapy and intraoperative radiofrequency ablation for unresectable solid pseudopapillary tumor of the pancreas.

Solid pseudopapillary tumor (SPT) is rare primary tumor of the pancreas with low malignant potential affecting adolescent or young women. Radical surgical resection is the definitive treatment for long-term survival even in the patients with metastases. We report a case of 14-year-old girl who presented with unresectable SPT of the pancreas. She received preoperative chemotherapy with cisplatinum, ifosfamide, etoposide, and vincristine followed by intraoperative radiofrequency ablation of metastatic liver lesions with surgical resection of the primary tumor successfully. We demonstrate that all attempts should be made to resect or ablate the primary as well as the metastatic lesions for long-term survival.

Prenatal diagnostic clue for fetus in fetu.

The purpose of this paper is to define a prenatal diagnostic clue for fetus in fetu (FIF) based on the characteristic findings of four FIF cases studied by the authors. A retrospective analyses of prenatal ultrasonography (US), postnatal US, computed tomography (CT) scans and operative findings were carried out on each of the four FIF cases collected from a multi-center. Prenatal US findings for each of the four cases showed a fluid-filled sac with a solid portion "floating" within it. In addition, bony structures were found in the solid portion. In each of the four cases, the postpartum imaging studies were consistent with the prenatal US findings. Operative findings revealed a solid mass within a fluid-filled sac surrounded by a transparent membrane. The solid mass was connected to the membrane by a stalk. Histopathologically, the cells making up the sac were of the same type as those of the amnion, while the solid mass had the general characteristics of FIF. In conclusion, FIF can be suspected when prenatal US shows a solid mass with bony structures within a fluid-filled sac in a newborn.

Targeted expression of human MYCN selectively causes pancreatic neuroendocrine tumors in transgenic zebrafish.

The zebrafish model organism has been used extensively for studies of genetic pathways in development, indicating its potential applicability to cancer. Here we show that targeted expression of MYCN in cells of the pancreatic islet induces neuroendocrine carcinoma. Four transgenic fish developed abdominal tumors between 4 and 6 months of age, and histologic analysis revealed lobulated arrangements of neoplastic cells with expression of the MYCN transgene. The tumors also expressed insulin mRNA, and pancreatic exocrine cells and ducts were identified within the neoplasms, indicating a pancreatic origin for the tumor. Transmission electron microscopy revealed cytoplasmic, endocrine-dense core granules, analogous to those found in human neuroendocrine tumors. Our studies establish a zebrafish transgenic model of pancreatic neuroendocrine carcinoma, setting the stage to evaluate molecular pathways downstream of MYCN in this vertebrate forward genetic model system.