RESUMO
Objectives: Patients with prosthetic joint infections (PJIs) not suitable for curative surgery may benefit from suppressive antibiotic therapy (SAT). However, the usefulness of SAT in cases with a draining sinus has never been investigated. Methods: A multicentre, retrospective observational cohort study was performed in which patients with a PJI and a sinus tract were eligible for inclusion if managed conservatively and if sufficient follow-up data were available (i.e. at least 2 years). SAT was defined as a period of > â¯6 months of oral antibiotic therapy. Results: SAT was initiated in 63 of 72 (87.5â¯%) included patients. Implant retention during follow-up was the same in patients receiving SAT vs. no SAT (79.4â¯% vs. 88.9â¯%; p = 0 .68). In total, 27â¯% of patients using SAT experienced side effects. In addition, the occurrence of prosthetic loosening in initially fixed implants, the need for surgical debridement, or the occurrence of bacteremia during follow-up could not be fully prevented with the use of SAT, which still occurred in 42â¯%, 6.3â¯%, and 3.2â¯% of cases, respectively. However, the sinus tract tended to close more often (42â¯% vs. 13â¯%; p = 0 .14), and a higher resolution of pain was observed (35â¯% vs. 14â¯%; p = 0 .22) in patients receiving SAT. Conclusions: SAT is not able to fully prevent complications in patients with a draining sinus. However, it may be beneficial in a subset of patients, particularly in those with pain or the hindrance of a draining sinus. A future prospective study, including a higher number of patients not receiving SAT, is needed.
