RESUMO
PROBLEM: To evaluate the inflammatory pattern in maternal circulation from women with preterm premature rupture of membranes (PPROM) considering the occurrence of histologically confirmed chorioamnionitis (HCA). METHOD OF STUDY: A prospective study was conducted in 121 women with PPROM between 24 and 34 + 0 weeks of gestation. Association between white blood cells (WBC) count, plasma CRP, IL-6, MCP-1 and IP-10 levels, and HCA was assessed. RESULTS: The rate of HCA was 44.7% (54/121). During the 5 days preceding delivery, median CRP, WBC, and IL-6 levels were significantly higher in the HCA than in no-HCA group (P < 0.001). Variations in IL-6, IP-10 levels, during the 24-72 hr before delivery, were predictors of the occurrence of HCA, but the diagnostic accuracy was low [Receiver Operating Characterictic (ROC) curve, area under the curve (AUC) = 0.56]. CONCLUSION: An increase in IL-6, CRP, IP-10 maternal plasma levels was confirmed in PPROM women with HCA. Longitudinal follow-up of these markers did not add valuable information regarding HCA.
Assuntos
Âmnio/patologia , Corioamnionite/diagnóstico , Trabalho de Parto Prematuro/diagnóstico , Ruptura/diagnóstico , Adulto , Biomarcadores/metabolismo , Proteína C-Reativa/metabolismo , Corioamnionite/imunologia , Citocinas/sangue , Feminino , Seguimentos , Humanos , Mediadores da Inflamação/metabolismo , Contagem de Leucócitos , Trabalho de Parto Prematuro/imunologia , Circulação Placentária/imunologia , Valor Preditivo dos Testes , Gravidez , Prognóstico , Estudos Prospectivos , Ruptura/imunologiaRESUMO
In this study, the fungistatic activity of Bacillus cereus cereulide-producing strains was demonstrated against nine fungal species. The role of cereulide was confirmed using plasmid-cured derivatives and ces knockout mutants. The fungistatic spectra of cereulide and valinomycin, a chemically related cyclododecadepsipeptide, were also compared and found to be similar but distinct.
