Artificial Intelligence Meets Neuro-Ophthalmology.

ABSTRACT: Recent advances in artificial intelligence have provided ophthalmologists with fast, accurate, and automated means for diagnosing and treating ocular conditions, paving the way to a modern and scalable eye care system. Compared to other ophthalmic disciplines, neuro-ophthalmology has, until recently, not benefitted from significant advances in the area of artificial intelligence. In this narrative review, we summarize and discuss recent advancements utilizing artificial intelligence for the detection of structural and functional optic nerve head abnormalities, and ocular movement disorders in neuro-ophthalmology.

Incidence and analysis of sharps injuries and splash exposures in a tertiary hospital in Southeast Asia: a ten-year review.

INTRODUCTION: We aimed to report the ten-year incidence and trend of sharps injuries and splash exposures (SISE), and analyse the causative instruments and risk factors leading to these injuries to identify potential areas of improvement. METHODS: A retrospective review of self-reported SISE incidents from 2005 to 2014 was conducted in Singapore General Hospital. Data was extracted from the electronic database of the Department of Infection Prevention and Control. Incidence of SISE was calculated per 1,000 healthcare workers (HCWs) per year. RESULTS: Over the ten-year period, a total of 1,901 SISE were reported. The average SISE incidence per year was 110.5 per 1,000 doctors and 22.8 per 1,000 nursing staff, with an overall incidence of 28.9 per 1,000 HCWs. The incidence of SISE decreased from 30.3 to 22.0 per 1,000 HCWs per year from 2005 to 2014, while that for splash exposures increased from 1.9 to 3.7 per 1,000 HCWs per year. Doctors reported the highest number of SISE (43.7%), followed by nurses (37.7%). Top mechanisms of injury were intraoperative procedures (22.8%), drawing blood (14.4%) and splash exposures (13.7%). CONCLUSION: Overall incidence of SISE decreased over the decade. Improved training and increasing use of safety devices, education and awareness could have contributed to the fall in incidence of sharps injuries; these measures should be reinforced and continued. However, the incidence of splash exposures increased over the same period. Preventive measures such as the use of protective goggles and face shields, together with personal protective equipment, should be emphasised and encouraged.

Radiologic Parameters of Orbital Bone Remodeling in Thyroid Eye Disease.

Purpose: To radiologically examine for the presence of bony remodeling of the orbit in thyroid eye disease (TED). Methods: Computed tomography (CT) scans of 248 orbits of 124 patients with TED and 185 orbits of 138 controls were retrospectively reviewed, and the following parameters measured: the angle of the inferomedial orbital strut (AIOS), the angle of the medial wall (AMW), and the diameters of the extraocular muscles. The association of TED with the AIOS or AMW was analyzed with linear regression models, and the correlations between the AMW or AIOS measurements with the extraocular muscle measurements were determined. Results: Overall, the AIOS was found to be larger (P < 0.001) and the AMW smaller (P = 0.045) in patients with TED compared to controls. After adjusting for age and sex, the larger AIOS in TED remained significant (P < 0.001), but the smaller AMW in TED patients was no longer significant (P = 0.07). There was a negative correlation between AMW and the calculated average cross-sectional area of the medial rectus in TED (r = -0.23, P = 0.01). Conclusions: A difference in the structure of the bony orbit in TED compared to controls may be demonstrated by the AIOS and AMW radiological parameters. This likely represents the presence of bony remodeling in TED, which may be related to the expansion of the intraorbital soft tissue volume.

Incidence and risk factors of symptomatic dry eye disease in Asian Malays from the Singapore Malay Eye Study.

PURPOSE: To evaluate the incidence of symptomatic dry eye disease (SDED) and associated risk factors in a well-characterized cohort of ethnic Malays in Singapore. METHODS: We included 1682 participants (mean age [SD]: 57 [10]years; 55.4% female) without SDED from the Singapore Malay Eye Study (SiMES), a population-based longitudinal study with baseline examination (SiMES-1) conducted between 2004 and 2006, and follow-up examination (SiMES-2) conducted between 2010 and 2013. SDED was considered to be present if a participant answered "often" or "all the time" to any of the six questions from the Salisbury Eye Evaluation Study dry eye questionnaire. Age-standardized incidence of SDED was calculated as the crude 6-year cumulative incidence standardized to Singapore's population census. Gender-stratified multivariable log-binomial regression models were utilized to determine the independent risk factors of incident SDED. RESULTS: At the 6-year follow-up, 86 of 1682 participants had developed SDED, which was equivalent to an age-standardized 6-year incidence of 5.1% (95% CI 4.1-6.4%). There were no differences in the incidence of SDED between men and women (P = 0.9). Multivariable models revealed that presence of glaucoma and poorer self-rated health were independently associated with incident SDED in men (P = 0.003 and 0.03, respectively), while contact lens wear (P = 0.002), history of thyroid disease (P = 0.03), and having had cataract surgery (P = 0.02) were predictive of incident SDED in women. CONCLUSION: One in twenty adult Malays developed SDED over a 6-year period. Risk factors for incident SDED were different between men and women. Future studies and public health interventions should consider this gender-specific difference in risk factors.

Barrier function in the ocular surface: from conventional paradigms to new opportunities.

By providing a physical and immunological barrier, the ocular surface serves the important function of protecting the vision apparatus. The barrier function keeps the cornea relatively dehydrated, preserving transparency for transmission of light. In many instances, dysfunction of this barrier leads to clinical diseases, such as dry eye, infectious keratitis, allergic keratoconjunctivitis, chemical injury, and persistent epithelial defects. Herein, we review the components of the epithelial barrier in the ocular surface, i.e., the transcellular and paracellular pathways, and describe the methodologies for measuring barrier function in vitro, in animals, and in clinical studies. The usefulness and limitations of these techniques are discussed. Recent studies in the regulation of individual tight junction proteins, the occludins, the zonula occludens, and the claudins, are also reviewed. Several potential interventional strategies based on the knowledge gained from these studies are noted.