[Study of photodynamic treatment for P-388 lympho-leukemia in mice].

Data are presented on the results of photodynamic treatment (PDT) of mice DBA2 with transplantable lympho-leukemia P-388. Different regimens of photosensitizer Dimegin and emission were used. Both intravenous PDT and in combination with local PDT should be recommended.

[Biological effects of Lamipharen photodynamic therapy].

Biological effects of Lamipharen treatment of sarcoma M-1 was studied in newborn rats and photodynamic therapy in combination with radiation was evaluated.

[State of the progeny of the 1st generation conceived at different times after low-dose irradiation of female rats]. / Sostoianie potomstva pervogo pokoleniia, zachatogo v razlichnye sroki posle oblucheniia samok v malykh dozakh.

The relation between the antenatal and early postnatal ontogenesis of the progeny and the degree of maturity of oocytes at the time of the whole single gamma-irradiation with doses of 0.25, 0.5 and 1 Gy was studied on 473 first pregnant Wistar rats and 1402 rats of the first generation. Ontogenesis disorders ot the progeny of these females after irradiation of the matured oocytes were more marked than after irradiation of the maturing oocytes. The distinction was noticeable after a dose of 0.25 Gy.

[The postnatal development of the progeny of males whose germ cells were irradiated at different stages of spermatogenesis]. / Postnatal'noe razvitie potomstva samtsov, polovye kletki kotorykh oblucheny na raznykh stadiiakh spermatogeneza.

Distinct genetic radiosensitivity of germinal cells of males irradiated during different stages of spermatogenesis with doses of 0.25-5.0 Gy leads to reduction in vital newborn rats number in the first generation progeny and to elevated postnatal mortality rate. These postnatal ontogeny disorders depend on the irradiation dose and spermatogenesis stage for a moment irradiation.

[Consequences for the intrauterine development of the offspring of the irradiation of male germinal cells at different stages of spermatogenesis]. / Posledstviia dlia vnutriutrobnogo razvitiia potomstva oblucheniia polovykh kletok samtsov na raznykh stadiiakh spermatogeneza.

Single whole-body exposure of adult male rats Wistar in different stages of spermatogenesis to gamma-rays (doses from 0.25 to 5.00 Gy) resulted in violations of antenatal development of the first generation offsprings. The pronouncement of these violations depends on the spermatogenesis stage in the moment of irradiation and exposure dose.