[Cytogenic chorionic nodule of the uterus]. / Le nodule du chorion cytogène de l'utérus.

The authors report five observations of endometrial stromal nodules. These nodules are composed of cells identical to those of the endometrial stroma. They constitute the benign form of endometrial stromal tumors. From the macroscopic point of view, they present as nodular formations, most often single, well defined, non-fasciculated, whitish or yellowish sometimes cystisized. From the microscopic point of view, these nodules contain areas of plexiform or glandular arrangement with, occasionally, pseudo-rosettes. Small collagenous zones can often be observed. E.S.N. should be distinguished on the one hand from endolymphatic stromal myosis, and on the other hand from sarcoma of the endometrial stroma. Histogenesis of the lesion is also discussed.

Multihormonal carcinoid tumor of the pancreas. Secreting growth hormone-releasing factor as a cause of acromegaly.

This report describes the histologic, immunocytochemical, and ultrastructural study of a multihormonal carcinoid tumor of the pancreas, secreting a growth hormone releasing factor (GRF) which provoked acromegaly. The patient presented a nonfamilial multiple endocrine neoplasia, type 1. The absence of radiologic signs of a pituitary adenoma in conjunction with elevated plasma levels of pancreatic polypeptide, glucagon, somatostatin, as well as growth hormone (GH), led to the discovery of the tumor. Its surgical excision produced a rapid disappearance of most of the clinical and biologic disorders. No immunoreactive GH was found in the tumor using radioimmunoassay and immunocytochemistry. In contrast, three peptides with GH-releasing activity were extracted and characterized. Immunocytochemistry showed that the GRF-reactive cells, together with rare somatostatin-storing cells, made up areas which demonstrated a medullary pattern of growth with extracellular amyloid deposits. Under electron microscopic examination, actively secreting cells were observed which carried endocrine granules of 100 to 150 nm in diameter. The other regions of the tumor presented a different type of growth and were composed of pancreatic polypeptide-, glucagon-, or somatostatin-reacting cells. Cells immunostained with antisera raised against beta-endorphin were also noted. These data suggest that GRF may be a new biologic marker for pancreatic endocrine tumors.

[Quantitative histology of papillary tumors of the bladder. Prognostic value]. / Histologie quantitative des tumeurs papillaires de vessie. Valeur pronostique.

Morphometry was applied to quantitate characteristic microscopical features of the removed non invasive papillary bladder tumours in 60 patients and of the normal urothelium in 13 cases. The measurements of nuclear areas were made on routine HES section with a microscopic digitiser (ASM-Leitz). There was a significant difference, concerning the average nuclear area, between normal urothelium and bladder tumours and also a correlation between the number of relapses at two years and this parameter. A significant difference existed for the average nuclear area of tumour without any relapse and the tumours with one or several relapses (p less than 0,02). A difference existed also between the tumours that caused cystectomie or early death and other tumours (p less than 0,01). The anisocaryosis (evaluated by the mean of the coefficient of variation of the average nuclear area) was greater in cases of tumours with bad prognosis (death). These results confirm the prognostic value of morphometric parameters in the histological analysis of papillary bladder tumours.

Simultaneous onset of ulcerative colitis in the rectum and in a segment of colon used for colpopoiesis: report of a case.

A patient is described in whom a segment of colon used to construct an artificial vagina was therefore removed from intestinal continuity and was affected by typical idiopathic ulcerative colitis. The onset of disease was simultaneous in this loop of colon and in the rectum. There was no evidence of local infection. An increased ratio of IgE-plasma cells was found in both the mucosa of the grafted colon and that of the rectum, but anticolonic antibodies were not detected in the serum. After removal of the loop of colon used for colpopoiesis, the patient continued to suffer from distal proctocolitis for almost a year, but has since then maintained a stable remission without treatment. The etiology of ulcerative colitis is discussed, and attention is drawn to the unusual psychologic aspects of this case.

[Severe ulcerated forms of acute colitis with unknown etiology. Recovery after total colectomy. Study of 2 cases (author's transl)]. / Colite aiguë grave à forme ulcérée, d'étiologie inconnue. Guérison après colectomie totale.

The authors report on two cases of severe ulcerated forms of acute colitis, successfully treated by total colectomy. Laboratory and X-ray investigations, as well as pathological examination of the removed section did not provide a definite etiopathologic classification. They voice the hypothesis of an infectious involvement and discuss the diagnostic and therapeutic problems evoked by these ulcerated forms of acute colitis. These are distinct from Crohn's disease and from ulcerative colitis. Their etiology remains unknown.

[Benign tumours of the liver and oral contraceptives (author's transl)]. / Tumeurs hépatiques bénignes et contraception orale.

The pathologic features, the terminology, the etiolgoy, and the causal relations of benign tumours of the liver associated with the use of oral contraceptives were reviewed during a study on six new cases. According to the literature the following points are emphasized: these tumours can be divided into two distinctive conditions, they are commonly called focal nodular hyperplasia and liver cell adenoma, whereas the name hamartoma seems rarely appropriated, they occur without any use of oral contraceptive, but this practice is probably responsible for their increasing number.

[Benign tumours of the liver and oral contraceptives (author's transl)]. / Tumeurs hépatiques bénignes et contraception orale.

PIP: During their observations of 6 new cases of benign liver tunors, the authors review the terminology commonly used to describe such lesions. These tumors belong to 2 different morphological varieties, nodular focal hyperplasia, and liver cell carcinoma. The exact role of estroprogestational agents in the appearance of benign liver neoplasms is still discussed, since such tumors have been described outside of oral contraception, before the existence of oral contraception, and also in men and children. However, statistical studies show that their incidence augments in women on oral contraception; that, possibly, estrogen only is the cause of hepatic lesions, and that duration of treatment does not influence the appearance of such lesions. Benign hyperplasic and benign adenomas are very susceptible of evolution toward malignant tumoral forms.^ieng

[Association of a bifocal nephroblastoma with Beckwith's syndrome]. / Association d'un nephroblastome bifocal a un syndrome de Wiedemann-Beckwith

A nephroblastoma occurred in the evolution of a case of Beckwith's syndrome. This rare association is not fortuitous. The bifocal character of the tumor is noted for the first time in the Beckwith's syndrome; however, it has already been observed in other conditions, which are known to promote the development of nephroblastomas. Wilm's tumor is only one of the tumors which may be associated with Beckwith's syndrome. These morbid associations and certain histological features bring together some material for the understanding of the nature of the histo-genetic relationship between different aspects of constitutional pathology and tumors.

[Histometric study of 55 cases of carcinoma in situ and microinvasive carcinoma of the cervix. Histogenetic deductions]. / Etude histométrique de 55 cas de carcinomes in situ et micro-invasifs du col utérin. Déductions histogénétiques.

The authors present the results of a quantitative study of carcinoma-in-situ and occult invasive cancers of the cervix. 40 separate carcinomata in-situ were measured and the limits of their topography precisely defined with reference to the external os on the one hand and the "last gland" on the other. It is known that this gland is situated at the site of the original junction between the cylindrical and pavement epithelia. It confirms that carcinoma-in-situ always (with few exceptions) develops upwards from the area of the original junction between the cylindrical and pavement epithelia, and its topography is higher than that of dysplasia especially when the two types of lesion are associated.

PIP: The height, length, proportion of the cervical circumference and location, with respect to the external os and the last gland or original junction between the cylindrical and pavement epithelia, of 40 carcinoma in situ and 15 occult invasive cervical cancers were analyzed histometrically. These 55 tissues were taken from a series of 74 conizations and 7 hysterectomies done in 1970-1973. 3 types of carcinoma in situ, or undifferentiated epithelia were distinguished: undifferentiated (none in this series), well differentiated (7), and somewhat differentiated (33 cases). These lesions averaged 8 mm long, 60.2% of the circumference and 90% involved glands. Usually small lesions (less than 5 mm) covered less than half of the circumference, while those over 10 mm covered 70%, and 75% invaded the glands. More than half were associated with dysplasia. 2 specimens had 2 carcinoma in situ lesions separated by healthy tissue and 6 were separated by dysplastic tissue. Topographically, the majority were located at the orifice, or, with respect to the last gland, located in the endocervix. Microinvasive carcinomas, or those invading the cervical stroma, occurred either as incipient invasive (less than 3 mm from the basal memabrane) or true microinvasive forms (3-8 mm deep, with stromal inflammation, irregular contours, larger cells than the epithelial carcinoma). Invasive carcinomas were larger deeper, covered more surface and glandular area, although their location was the same as that of cancer in situ. It is proposed that cervical cancer may develop after puberty when metaplasia and cervical eversion coincide with exposure to Herpes 2 virus. They argued that carcinoma and dysplasia do not share the same typography, so they may be 2 separate entities.