RESUMO
Sixty children infected with Mycobacterium tuberculosis (MBT), aged 3 to 5 years were followed up in the period before specific chemotherapy. The studies established structural and functional changed in the immune system in young MBT-infected children. Moreover, the disorders found in immune homeostasis were of combined nature. This circumstance should be taken into account in elaborating immune rehabilitative programs for this group of patients.
Assuntos
Mycobacterium tuberculosis/imunologia , Tuberculose Pulmonar/imunologia , Antígenos CD/sangue , Pré-Escolar , Humanos , Imunidade Celular , Imunoglobulina G/sangue , Imunoglobulina M/sangue , Mycobacterium tuberculosis/isolamento & purificação , Mycobacterium tuberculosis/patogenicidade , Tuberculose Pulmonar/sangue , Tuberculose Pulmonar/prevenção & controleRESUMO
Sixty children infected with Mycobacteria tuberculosis from two age groups (3-5 and 12-14 years) were followed up. The phagocytic activity and oxygen-dependent biocidicity of peripheral neutrophilic granulocytes were studied. The studies indicated dysfunctions of neutrophilic granulocytes in the children infected with Mycobacteria tuberculosis. This fact should be borne in mind in developing immunorehabilitative programmes in this category of patients. Moreover, the changes in the killing activity of neutrophilic turned out to be more pronounced in a young age group. In this connection, immunomodulating therapy should be strictly differentiated.