Hemangioma capilar lobulado asociado a hiperplasia de células de Leydig testicular en adulto añoso: presentación de un caso / Testicular capillary hemangioma and Leydig cell hyperplasia in an elderly patient: A case report

La combinación de hemangioma capilar (HC) lobulado testicular con hiperplasia de células de Leydig es excepcional. Presentamos un caso en un varón de 72 años, con antecedente de seminoma testicular izquierdo hace 34 años, que consultó por asimetría mamaria. El estudio ultrasónico testicular mostró en el testículo derecho una lesión sólida, hipoecogénica, de 0,6 cm, con flujo vascular central y periférico. Los niveles de β-HCG, LH, estradiol y testosterona fueron normales. Mediante cirugía conservadora, con enucleación de la lesión, y biopsia intraoperatoria se confirmó la benignidad de la lesión. De acuerdo con lo revisado en la literatura, el presente caso sería el primer HC asociado a hiperplasia de células de Leydig en un adulto mayor (AU)

Lobulated capillary hemangioma with Leydig cell hyperplasia in the same nodule is exceptional. We report a case of a 72 year old male presenting with mammary asymmetry. Thirty seven years previously he had had a left sided testicular seminoma. Testicular ultrasonography of the right testicle revealed a 0.6 cm hypoecogenic nodule, which was solid with central and peripheral vascular flux. Beta-HCG, LH, estradiol and total testosterone levels were normal. Enucleation of the lesion was performed and an intraoperatory biopsy confirmed a benign lesion. The definitive diagnosis was lobulated capillary hemangioma with Leydig cell hyperplasia. To our knowledge, this is the first case reported in an adult (AU)

[Combined periampullary adenocarcinoma and neuroendocrine tumor in type 1 neurofibromatosis: report of one case]. / Carcinoma mixto adenocarcinoma y neuroendocrino periampular en un paciente con neurofibromatosis tipo 1: Caso clínico.

Neurofibromatosis is a hereditary autosomal-dominant disease with high rates of de novo mutations, and carries a high risk of neoplasms. It affects both sexes and all races and ethnic groups. It is characterized by multiple cutaneous lesions and tumors, both benign and malignant, especially in the nervous system. We report a 52-year-old woman with a type 1 neurofibromatosis, presenting with fever, jaundice and weight loss. On physical examination, the patient was jaundiced and had "café au lait" spots in the skin. A magnetic resonance imaging showed bile duct dilation and a possible ampullar carcinoma. The patient was operated, during the exploration she presented a periampullary tumor and multiple small nodular lesions in the stomach, the tumor was resected with a pancreaticoduodenectomy and the nodular gastric lesions were biopsied. The pathological study revealed a combined adenocarcinoma and neuroendocrine duodenal tumor. The study of the stomach lesions revealed a gastrointestinal stromal tumor. Four months after surgery, the patient is in good condition.

Carcinoma mixto adenocarcinoma y neuroendocrino periampular en un paciente con neurofibromatosis tipo 1: Caso clínico / Combined periampullary adenocarcinoma and neuroendocrine tumor in type 1 neurofibromatosis: Report of one case

Neurofibromatosis is a hereditary autosomal-dominant disease, with high rates ofde novo mutations and carries a high risk ofneoplasms. It affects both sexes and all races and ethnic groups. It is characterized by múltiple cutaneous lesions and tumors, both benign and malignant, especially in the nervous system. We report a 52 years old woman with a type 1 neurofibromatosis, presenting with fever, jaundice and weight loss. Onphysical examination, thepatientwasjaundiced and had "café au lait" spots in the skin. A magnetic resonance imaging showed bile duct dilation and a possible ampullarcarcinoma. Thepatientwas operated, duringthe exploration shepresented a periampullary tumor and múltiple small nodular lesions in the stomach, the tumor was resected with a pancreático dúo denectomy and the nodular gastric lesions were biopsied. Thepathological study revealed a combined adenocarcinoma and neuroendocrine duodenal tumor. The study ofthe stomach lesions revealed a gastrointestinal stromal tumor. Four months after surgery, the patient is in good conditions.