[PCR diagnosis of sequences of a novel human herpes virus type 8 in patients with Kaposi sarcoma in Russia]. / PTsR-diagnostika posledovatel'nostei novogo gerpesvirusa cheloveka 8-go tipa u bol'nykh sarkomoi Kaposhi v Rossii.

Associations of a new human herpesvirus type 8 (HHV-8) with different forms of Kaposi's sarcoma (KS) in Russia have been studied. Search for this virus genetic information has been carried out in biopsy specimens of benign and malignant tumors other than KS, and probable sites of HHV-8 latency in human body have been checked. HHV-8 sequences were detected by polymerase chain reaction (PCR). HHV-8 sequences were most often detected in idiopathic (80.6%), AIDS-associated (80%), and immunosuppressive (100%) KS. The results indicate a selective association of HHV-8 with KS. No probable sites of the virus latency were detected in peripheral blood cells of patients with KS and in the prostate of patients with chronic prostatitis. The only exception was the husband of a patient with KS: HHV-8 sequences were detected in his prostatic secretion by nested PCR.

[Primary skin lymphomas: phenotypic characteristics of major clinical variants, classification]. / Pervichnye limfomy kozhi: fenotipicheskaia kharakteristika osnovnykh klinicheskikh form, klassifikatsii.

Clinicomorphological characteristics of the most frequent forms of primary malignant skin lymphoma are given and their place in classifications of systemic diseases of hematopoietic and lymphoid tissue is shown. The use of specialized dermatological classification in practice of dermatologists is recommended.

[The immunocompetent structures of the skin and their role in the development of primary skin lymphomas]. / Immunokompetentnye struktury kozhi i ikh rol' v razvitii pervichnykh kozhnykh limfom.

Participation in immune reactions of main morphological skin structures (epidermal cells, skin associated lymphoid tissue, macrophagal and vascular systems) is described. Cooperation of these systems in immune reaction by means of complementary receptors on the cell membranes, adhesive molecules, cytokines and lymphokines is discussed. Primary malignant skin lymphomas are considered as tumors of the skin immune system.

[The use of H-1 antihistamine preparations in neurodermatitis patients]. / Primenenie H-1 antigistaminnykh preparatov u bol'nykh neirodermitom.

Correlations between clinical variants of neurodermatitis course and patients' lymphocyte sensitivity to histamine are analyzed. The atopic form is associated with high lymphocyte sensitivity to histamine. Administration of H-1 antihistaminic agents to these patients is not always justified. Antihistaminic drugs should be prescribed to neurodermatitis patients with due consideration for the individual sensitivity of patient's lymphocytes to histamine.

[Clinico-immunologic characteristics of patients with seroresistant syphilis]. / KLiniko-immunologicheskaia kharakteristika bol'nykh serorezistentnym sifilisom.

Clinical and immunological analysis of patients with seroresistant syphilis has revealed a number of immunological shifts. The authors emphasize that only immunologically based therapy may be prescribed to patients with seroresistant syphilis.

[Characteristics of the development of experimental allergic contact dermatitis]. / O nekotorykh osobennostiakh razvitiia éksperimental'nogo allergicheskogo kontaktnogo dermatita.

Histological and electron microscopic examination of changes in the skin and blood revealed three different stages in the development of experimental allergic contact dermatitis (ACD). The primary contact reaction (24 hours) had features of nonspecific inflammation with some morphological signs of initial sensitization. Inflammation in the flare-up reaction (5-7 days) is the result of the immune process, and basophilic infiltration of the skin is the obligatory component of this reaction. ACD (patch test at 15 days) was shown to have morphological manifestations typical of the delayed type hypersensitivity and some signs of the immediate type reactions.