1.
Mil Med
; 168(3): 246-51, 2003 Mar.
Artigo
em Inglês
| MEDLINE
| ID: mdl-12685693
RESUMO
This study evaluated the effectiveness of five human monoclonal antibodies in comparison with human polyclonal antibodies, F(ab')2, amantadine, and zanamivir in a mouse model of lethal influenza A virus infection. A single intranasal administration of antibodies was done for immunoprophylaxis. Zanamivir was administered intranasally and amantadine was administered orally. Mice were fully protected by a single dose of 30 mg/kg intravenous Ig administered at least 3 days before challenge. This treatment was equivalent to zanamivir. F(ab')2 were less effective (p < 0.001). One of the monoclonal antibodies tested was less efficient than both zanamivir (p < 0.001) and intravenous Ig (p < 0.001) but similar to amantadine.