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Notopterygium, a plant genus belonging to the Apiaceae family, is utilized in traditional Chinese medicine for its medicinal properties. Specifically, the roots and rhizomes of these plants are employed in phytotherapy to alleviate inflammatory conditions and headaches. This review provides a concise overview of the existing information regarding the botanical description, phytochemistry, pharmacology, and molecular mechanisms of the two Notopterygium species: Notopterygium incisum and N. franchetii. More than 500 distinct compounds have been derived from these plants, with the root being the primary source. These components include volatile oils, coumarins, enynes, sesquiterpenes, organic acids and esters, flavonoids, and various other compounds. Research suggests that Notopterygium incisum and N. franchetii exhibit a diverse array of pharmacological effects, encompassing antipyretic, analgesic, anti-inflammatory, antiarrhythmic, anticoagulant, antibacterial, antioxidant, and anticancer properties on various organs such as the brain, heart, digestive system, and respiratory system. Building activity screening models based on the pharmacological effects of Notopterygium species, as well as discovering and studying the pharmacological mechanisms of novel active ingredients, will constitute the primary development focus of Notopterygium medicinal research in the future.
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Apiaceae , Compostos Fitoquímicos , Apiaceae/química , Humanos , Compostos Fitoquímicos/química , Compostos Fitoquímicos/farmacologia , Medicina Tradicional Chinesa , Medicamentos de Ervas Chinesas/química , Medicamentos de Ervas Chinesas/farmacologia , Medicamentos de Ervas Chinesas/uso terapêutico , Animais , Anti-Inflamatórios/farmacologia , Anti-Inflamatórios/química , Extratos Vegetais/química , Extratos Vegetais/farmacologia , Raízes de Plantas/químicaRESUMO
BACKGROUND: The construction of gels from low molecular weight gelators (LMWG) has been extensively studied in the fields of bio-nanotechnology and other fields. However, the understanding gaps still prevent the prediction of LMWG from the full design of those gel systems. Gels with multicomponent become even more complicated because of the multiple interference effects coexist in the composite gel systems. AIM OF REVIEW: This review emphasizes systems view on the understanding of multicomponent low molecular weight gels (MLMWGs), and summarizes recent progress on the construction of desired networks of MLMWGs, including self-sorting and co-assembly, as well as the challenges and approaches to understanding MLMWGs, with the hope that the opportunities from natural products and peptides can speed up the understanding process and close the gaps between the design and prediction of structures. KEY SCIENTIFIC CONCEPTS OF REVIEW: This review is focused on three key concepts. Firstly, understanding the complicated multicomponent gels systems requires a systems perspective on MLMWGs. Secondly, several protocols can be applied to control self-sorting and co-assembly behaviors in those multicomponent gels system, including the certain complementary structures, chirality inducing and dynamic control. Thirdly, the discussion is anchored in challenges and strategies of understanding MLMWGs, and some examples are provided for the understanding of multicomponent gels constructed from small natural products and subtle designed short peptides.
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Achieving high gas selectivity is challenging when dealing with gas pairs of similar size and physiochemical properties. The "molecular trapdoor" mechanism discovered in zeolites holds promise for highly selective gas adsorption separation but faces limitations like constrained pore volume and slow adsorption kinetics. To address these challenges, for the first time, a flexible metal-organic framework (MOF) featuring 1D channels and functioning as a "molecular trapdoor" material is intoduced. Extra-framework anions act as "gate-keeping" groups at the narrowest points of channels, permitting gas admissions via gate opening induced by thermal/pressure stimuli and guest interactions. Different guest molecules induce varied energy barriers for anion movement, enabling gas separation based on distinct threshold temperatures for gas admission. The flexible framework of Pytpy MOFs, featuring swelling structure with rotatable pyridine rings, facilitates faster gas adsorption than zeolite. Analyzing anion properties of Pytpy MOFs reveals a guiding principle for selecting anions to tailor threshold gas admission. This study not only overcomes the kinetic limitations related to gas admission in the "molecular trapdoor" zeolites but also underscores the potential of developing MOFs as molecular trapdoor adsorbents, providing valuable insights for designing ionic MOFs tailored to diverse gas separation applications.
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Metallopolymers as organic-inorganic hybrid materials formulated by metal embedding organic polymers show great potential for novel heterogeneous catalysis, in terms of the facile structural design and tunability. Herein, the disadvantage of nonporous stacking of one-dimensional (1D) structures has been suppressed by chain modulation of the 1D metallopolymers, allowing for the convenient construction of porous assemblies with single-atom dispersion and accessible active sites. By postmodification, the Fe/CM-1 catalyst readily synthesized by coordinating the Fe(II) to the twisted chain of 1D Schiff-base polymer possesses expedient flexibility, showing the highest porosity, remarkable heterogeneous recyclability, and thus prominent catalytic activity for the selective oxidation of benzylamine and alcohols. Moreover, control experiments supported by computational studies demonstrated that the unique pincer structure of Fe/CM-1 effectively maintains the valence state of the anchored single-atom iron, facilitating single-electron transfer and promoting efficient iron redox cycling during the catalytic process. Notably, these 1D metallopolymers have the advantage of cost-effectiveness, easy preparation in gram-scale, and utilization in continuous reaction, providing inspirations for facile synthesis of efficient heterogeneous catalysts from the well-developed 1D metallopolymers.
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A novel crystalline covalent organic framework COF-NHPI was built by a bottom-up strategy to guarantee highly ordered embedment of the N-hydroxyphthalimide (NHPI) units as nitroxyl radical organocatalytic sites. The COF-NHPI was demonstrated to be a metal-free, highly selective and heterogeneous catalyst for the efficient oxidation of various silanes to the corresponding silanols. Mechanistic studies revealed that the critical phthalimido N-oxyl radical was generated in situ to govern the catalysis.
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With fast (de)coordination kinetics, the smallest and the lightest proton stands out as the most ideal charge carrier for aqueous Zn-organic batteries (ZOBs). Hydrogen-bonding networks with rapid Grotthuss proton conduction is particularly suitable for organic cathodes, yet not reported. We report the supramolecular self-assembly of cyanuric acid and 1,3,5-triazine-2,4,6-triamine into organic superstructures through in-plane H-bonds and out-of-plane π-π interaction. The supramolecular superstructures exhibit highly stable lock-and-key H-bonding networks with an ultralow activation energy for protonation (0.09â eV vs. 0.25â eV of zincification). Then, high-kinetics H+ coordination is prior to Zn2+ into protophilic C=O sites via a two-step nine-electron reaction. The assembled ZOBs show high-rate capability (135â mAh g-1 at 150â A g-1 ), high energy density (267â Wh kg-1 cathode ) and ultra-long life (50 000 cycles at 10â A g-1 ), becoming the state-of-the-art ZOBs in comprehensive performances.
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Covalent triazine frameworks (CTFs), served as a versatile platform, can form expedient metal-N single-atom coordination sites as promising catalytic centers. To seek out excellent candidate catalysts of M/CTFs (M = Transition metal) for nitrogen reduction reaction (NRR), a "five-step" strategy involving spin states has been established for hierarchical high-throughput screening and reveals strong coordination ability of the CTFs, outstanding conductivity of the M/CTFs, effective adsorption and activation of N2* attributed to the electron transfer and orbital hybridization between the M/CTFs and N2*. Among the potential candidates, the Cr/CTF is screened out to be an excellent one for nitrogen fixation, which can not only inhibit hydrogen evolution reaction (HER) greatly but also has good thermodynamic stability (Eb = -4.40 eV), narrow band gap (Eg = 0.03 eV), moderate adsorption energy (Ea = -0.84 eV), large activation energy (ΔGN2* = -0.71 eV) and a theoretical Faradaic efficiency of 100%. The spin state has been confirmed to be an important descriptor of catalytic activity and the two-state reactivity (TSR) is validated to exist in the NRR. Reaction mechanism with different spin states of Cr/CTF has been demonstrated to give a great impact on the nitrogen fixation, providing solid theoretical support for the design of more efficient NRR catalysts.
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Highly active and stable cathodes are critical for aqueous Zn-organic batteries with high capacity, fast redox kinetics, and long life. We herein report para-, meta-, and ortho-dinitrobenzene (p-, m-, and o-DB) containing two successive two-electron processes, as cathode materials to boost the battery performance. Theoretical and experimental studies reveal that nitro constitutional isomerism is key to zincophilic activity and redox kinetics. p-DB hosted in carbon nanoflower harvests a high capacity of 402â mAh g-1 and a superior stability up to 25 000â cycles at 5â A g-1 , giving a Zn-organic battery with a high energy density of 230â Wh kg-1 . An anionic co-insertion charge storage mechanism is proposed, entailing a two-step (de)coordination of Zn(CF3 SO3 )+ with nitro oxygen. Besides, dinitrobenzene can be electrochemically optimized by side group regulation via implanting electron-withdrawing motifs. This work opens a new window to design multielectron nitroaromatics for Zn-organic batteries.
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Photoresponsive arylsilanes have been fascinating molecules for decades because of their unique photophysical characteristics and surface chemistry. Here we report the synthesis and fabrication of a crystalline two-dimensional trisilyl metal-organic framework (TSiMOF) orderly installed with the classical photoresponsive hexamethyltrisilane groups on the surface. Irradiated by UV light under air in minutes the fluorescence of the TSiMOF is turned on simultaneously with an intriguing surface transformation from superhydrophobic to hydrophilic. Thus, multifarious luminescent and hydrophilic patterns including logos, characters and Quick Response codes, etc. with good resolution are readily generated on the facilely fabricated TSiMOF film. The mechanism of this transformation is revealed by control experiments that the superficial trimethylsilyl groups suffering photochemical oxidation have been converted to hydroxyl groups.
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An octa-nuclear zinc (Zn8) cluster-based two-fold interpenetrated metal-organic framework (MOF) of [(CH3)2NH2]2[Zn8O3(FDC)6]·7DMF (denoted as Zn8-as; H2FDC = 9H-fluorene-2,7-dicarboxylic acid; DMF = N,N-dimethylformamide) was synthesized by the reaction of a hard base of a curved dicarboxylate ligand (H2FDC) with the borderline acid of Zn(II) under solvothermal conditions. Zn8-as shows significant crystal volume shrinkage upon heating, yielding a solvate-free framework of [(CH3)2NH2]2[Zn8O3(FDC)6] (Zn8-de). Zn8-de displays gated adsorption for C2H2 and type-I adsorption for CO2, attributed to the framework flexibility and the different interactions between the gas molecules and the host framework.
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A series of symmetrical tetracyanobutadiene and tetracyanoquinodimethane derivatives with a D-A-D'-A-D structural configuration and silafluorene core (D') were designed and readily synthesized via a [2+2] cycloaddition-retroelectrocyclization (CA-RE) reaction. We found that the photophysical properties and HOMO and LUMO energy levels and gaps of the silafluorene derivatives could be profoundly remolded through CA-RE reactions and modulated by varying the peripheral donor units from phenyl, m-dimethoxyphenyl, and N,N-dimethylaniline to triphenylamine groups. After CA-RE reactions, the HOMO-LUMO gaps of 1a-1j are in the range of 1.75-2.78 eV, with significant decreases of 0.52-1.46 eV compared to those of the parent silafluorene compounds 2a-2j. The intriguing crystal structures of 1f and 1j were analyzed and elucidated to show their unique potential porosity. The stability, electrochemical, and computational studies were systematically performed to unveil the reshaped electron-donating and -withdrawing nature in one molecular system. 1h-1j with peripherally strong amino donors exhibit an intense and broad intramolecular charge transfer absorption band in the near-infrared region from 550 to 900 nm. The molecular design and synthesis reported here broaden the types and fields of D-A molecular systems for potential applications in organic optoelectronic devices.
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Designing ingenious and stable carbon nanostructures is critical but still challenging for use in energy storage devices with superior electrochemistry kinetics, durable capacitive activity, and high rate survivability. To pursue the objective, a simple self-assembly strategy is developed to access carbon superstructures built of nanoparticle embedded plates. The carbon precursors, 2,4,6-trichloro-1,3,5-triazine and 2,6-diaminoanthraquinone can form porous organic polymer with "protic salt"-type rigid skeleton linked by -NH2 + Cl- - "rivets", which provides the cornerstone for hydrogen-bonding-guided self-assembly of the organic backbone to superstructures by π-π plane stacking. The ameliorative charge density distribution and decreased adsorption energy in as-fabricated carbon superstructures allow the high accessibility of the build-in protophilic sites and efficient ion diffusion with a low energy barrier. Such superstructures thus deliver ultra-stable charge storage and fast proton-coupled kinetics at the structural-chemical defects, contributing to unprecedented lifespan (1 000 000 cycles), high-rate capability (100 A g-1 ) for carbon-based supercapacitors, and an ultrahigh energy density (128 Wh kg-1 ) for Zn-ion hybrid supercapacitors. The self-assembled carbon superstructures significantly improve the all-round electrochemical performances, and hold great promise for efficient energy storage.
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Self-assembly peptide-based hydrogels are well known and popular in biomedical applications due to the fact that they are readily controllable and have biocompatibility properties. A dipeptide is the shortest self-assembling motif of peptides. Due to its small size and simple synthesis method, dipeptide can provide a simple and easy-to-use method to study the mechanism of peptides' self-assembly. This review describes the design and structures of self-assembly linear dipeptide hydrogels. The strategies for preparing the new generation of linear dipeptide hydrogels can be divided into three categories based on the modification site of dipeptide: 1) COOH-terminal and N-terminal modified dipeptide, 2) C-terminal modified dipeptide, and 3) uncapped dipeptide. With a deeper understanding of the relationship between the structures and properties of dipeptides, we believe that dipeptide hydrogels have great potential application in preparing minimal biocompatible materials.
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Two highly efficient metal-organic framework catalysts TJU-68-NHPI and TJU-68-NDHPI have been successfully synthesized through solvothermal reactions of which the frameworks are merged with N-hydroxyphthalimide (NHPI) units, resulting in the decoration of pore surfaces with highly active nitroxyl catalytic sites. When t-butyl nitrite (TBN) is used as co-catalyst, the as-synthesized MOFs are demonstrated to be highly efficient and recyclable catalysts for a novel three-phase heterogeneous oxidation of activated C-H bond of primary and secondary alcohols, and benzyl compounds under mild conditions. Based on the high efficiency and selectivity, an environmentally benign system with good sustainability, mild conditions, simple work-up procedure has been established for practical oxidation of a wide range of substrates.
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Covalent triazine frameworks (CTFs) as a kind of covalent organic framework (COF) materials show great potential for practical application by virtue of their high stability and facile large-scale synthesis. In this work, we developed three CTFs (MSCTF-1, MSCTF-2, and xSCTF-2) of different pore size decorated with S-groups using different functionalization methods for achieving selective Hg2+ removal from aqueous solutions. The material structures were comprehensively studied by gas adsorption, IR and XPS, etc. Among them, the MSCTF-2 with 24.45% S content showed the highest Hg2+ adsorption capacity of 840.5 mg gâ1, while MSCTF-1 exhibiting much larger distribution coefficient of 1.67 × 108 mL gâ1 renders an exceptionally high efficiency for reducing the concentration of Hg2+ contaminated water to less than 0.03 µg Lâ1. Moreover, the MSCTFs show distinct features of: (i) high selectivity toward Hg2+ over various transition metal ions; (ii) high stability over a wide pH range from pH 1 to 12; and (iii) good recyclability with 94% of Hg2+ removal over five consecutive cycles. The Hg2+ adsorption on functionalized CTFs followed pseudo-second-order kinetics and Langmuir isotherm. Our results revealed the material structure-performance relationship that the adsorption capacities depend on the binding site density whereas the distribution coefficient is essential to the removal efficiency.
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Monolayer MoS2 (ML-MoS2) with various polymorphic phases attracts growing interests for device applications in recent years. Herein, a field-effect transistor (FET) gas sensor is developed on the basis of monolayer MoS2 with a heterophase of a 1T metallic phase and a 2H semiconducting phase. Lithium-exfoliated MoS2 nanosheets own a monolayer structure with rich active sites for gas adsorption. With thermal annealing from 50 to 300 °C, the initial lithium-exfoliated 1T-phase MoS2 gradually transforms into the 2H phase, during which the 1T and 2H heterophases can be modulated. The 1T/2H heterophase MoS2 shows p-type semiconducting properties and prominent adsorption capability for NO2 molecules. The highest response is observed for 100 °C annealed MoS2 of a 40% 1T phase and a 60% 2H phase, which shows a sensitivity up to 25% toward 2 ppm NO2 at room temperature in a very short time (10 s) and a lower limit of detection down to 25 ppb. This study demonstrates that the gas detection capability of ML-MoS2 could be boosted with the heterophase construction, which brings new insights into transition-metal dichalcogenide gas sensors.
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Self-assembling peptides can be used to design new materials for medical and biological applications. Here we synthesized and characterized two novel cyclic γ-peptides (γ-CPs) with hydrophobic inner surfaces. The NMR and FT-IR studies confirmed that the CPs could self-assemble into parallel stacking structures via intermolecular H-bonds and π-π interactions. The morphologies of the self-assembly CPs showed bundles of nanotubes via transmission electron microscopy (TEM); these nanotubes form water channels to transport water across the lipid membrane. The properties of blocking the transport of protons like natural water channels showed that the hydrophobic inner surfaces are important in artificial transmembrane water channel designs. These studies also showed that water transport was a function of pore size and length of the assemblies.
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The enhancement of gas adsorption utilizing weak interactions in porous compounds is highly demanding for the design of energy-efficient storage materials. Here, we present a rational design for such an adsorption process by using synergistic functions between dynamic motion in a local module and weak but specific host-guest interactions, that is, halogen-bond (XB) interactions in metal-organic frameworks (MOFs). We designed a new porous coordination polymer (PCP), that is, Br-PCP, the pore surfaces of which are decorated with -CH2 Br groups and could be useful for interaction with CO2 molecules. In accordance with our anticipation, in-situ studies suggest that the adsorption step at approximately 54â kPa during CO2 adsorption is indeed facilitated by XB interactions with little change in the structural volume. This approach of integrating flexible XB modules in rigid PCPs is applicable for designing advanced gas storage systems.
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N/O self-doped hollow carbon nanorods (HCNs) with micro/mesoporous walls are fabricated based on a new deep-eutectic-solvent that serves as an all-in-one precursor, self-template, and self-dopant agent. The carbon-based supercapacitor using an ionic liquid electrolyte exhibits a high energy density of 116.5 W h kg-1 with excellent long-term cycling performance.
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We reported a new polymorphous core-shell metal-organic framework (MOF) in the form of a three-dimensional MOF core wrapped in a two-dimensional layered MOF shell by applying a general acid-solvent synergy synthesis. This hybrid material can achieve high adsorptive selectivity/capacity simultaneously, which is validated by the unary isotherms of CO2 and N2 conducted at 273 K (0-1 bar). The MOF-S@MOF-C with a 7-day exchange showed the highest CO2/N2 selectivity (32.7) among our samples and a moderate CO2 capacity (2.3 mmol/g), which are 3 times and 1.6 times those of the MOF-C and MOF-S, respectively. We attributed the enhanced selective adsorption performance to the negligible N2 uptake exhibited by the outer shell of MOF-S@MOF-C. This study provides a new route for elevating gas separation performance by constructing multifunctional core-shell materials.